Results 71 to 80 of about 52,241 (196)
MPDZ promotes DLL4-induced Notch signaling during angiogenesis
eLife, 2018 Angiogenesis is coordinated by VEGF and Notch signaling. DLL4-induced Notch signaling inhibits tip cell formation and vessel branching. To ensure proper Notch signaling, receptors and ligands are clustered at adherens junctions.
Fabian Tetzlaff +7 more
doaj +1 more source
Chronic exposure to simulated space conditions predominantly affects cytoskeleton remodeling and oxidative stress response in mouse fetal fibroblasts [PDF]
, 2014 Microgravity and cosmic rays as found in space are difficult to recreate on earth. However, ground-based models exist to simulate space flight experiments.
Abou-El-Ardat, Khalil +11 more
core +2 more sources
Adherens Junctions Revisualized: Organizing Cadherins as Nanoassemblies [PDF]
Developmental Cell, 2015 This Perspective considers how classical cadherin cell-cell adhesion receptors are organized at the nanoscale to generate lateral clusters. Recent advances in optical microscopy reveal that clustering constitutes a general feature of cadherin organization, but one that takes diverse forms.
Yap, Alpha S. +2 more
openaire +4 more sources
Nature Communications, 2017 Epithelial cell-cell adhesions are contractile junctions, but whether contractility can be down-regulated is not known. Here the authors report how tyrosine dephosphorylation of the cytoskeletal scaffold, cortactin, recruits the RhoA antagonist SRGAP1 to
Xuan Liang +10 more
doaj +1 more source
Mechanosensitive Adaptation of E-Cadherin Turnover across adherens Junctions. [PDF]
PLoS ONE, 2015 In the natural and technological world, multi-agent systems strongly depend on how the interactions are ruled between their individual components, and the proper control of time-scales and synchronization is a key issue.
Simon de Beco +3 more
doaj +1 more source
Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]
, 2016 Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
Ali, Jawahir +7 more
core +1 more source
Atrial Natriuretic Peptide Protects against Histamine-Induced Endothelial Barrier Dysfunction in Vivo [PDF]
, 2008 Endothelial barrier dysfunction is a hallmark of many severe pathologies, including sepsis or atherosclerosis. The cardiovascular hormone atrial natriuretic peptide (ANP) has increasingly been suggested to counteract endothelial leakage.
Bihari, Peter +9 more
core +1 more source
αE-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation
Cell Reports, 2017 The development and function of epithelia depend on the establishment and maintenance of cell-cell adhesion and intercellular junctions, which operate as mechanosensor hubs for the transduction of biochemical signals regulating cell proliferation ...
Antonio J. Jimenez-Caliani +6 more
doaj +1 more source
PLoS ONE, 2012 BackgroundThe fibroblast growth factor (FGF) system plays a critical role in the maintenance of vascular integrity via enhancing the stability of VE-cadherin at adherens junctions. However, the precise molecular mechanism is not well understood.
Kunihiko Hatanaka +3 more
doaj +1 more source
Patologìâ, 2013 Background. Antenatal and prenatal hypoxia causes changes in all the organs of fetuses and newborns and in the heart, particularly. Hypoxic damage of the cardiovascular system occurs in 40-70% of newborns.
N. S. Petruk
doaj +1 more source