Results 21 to 30 of about 14,945 (190)

Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence

Nature Communications, 2023
The intrinsic virulence of extra-intestinal pathogenic Escherichia coli is associated with numerous chromosomal and/or plasmid-borne genes, encoding diverse functions such as adhesins, toxins, and iron capture systems.
Guilhem Royer, Olivier Clermont, Julie Marin, Bénédicte Condamine, Sara Dion, François Blanquart, Marco Galardini, Erick Denamur   +7 more
doaj   +1 more source

Lectin-Glycan Interaction Network-Based Identification of Host Receptors of Microbial Pathogenic Adhesins

mBio, 2016
The first step in the infection of humans by microbial pathogens is their adherence to host tissue cells, which is frequently based on the binding of carbohydrate-binding proteins (lectin-like adhesins) to human cell receptors that expose glycans.
Francesco S. Ielasi, Mitchel Alioscha-Perez, Dagmara Donohue, Sandra Claes, Hichem Sahli, Dominique Schols, Ronnie G. Willaert   +6 more
doaj   +1 more source

Adhesins as Targets for Vaccine Development

Emerging Infectious Diseases, 1999
Blocking the primary stages of infection, namely bacterial attachment to host cell receptors and colonization of the mucosal surface, may be the most effective strategy to prevent bacterial infections. Bacterial attachment usually involves an interaction
Theresa M. Wizemann, John E. Adamou, Solomon Langermann   +2 more
doaj   +1 more source

Detection of cytotoxic necrotizing factor types 1 and 2 among fecal Escherichia coli isolates from brazilian children with and without diarrhea

Memorias do Instituto Oswaldo Cruz, 2004
The enteropathogenic role of cytotoxic necrotizing factor (CNF)-producing Escherichia coli was investigated by searching cnf genes among 2074 isolates from 200 children with and 200 without acute diarrhea in Brazil.
Ana Terezinha Tavechio, Lilian Regina M Marques, Cecília Mari Abe, Tânia AT Gomes   +3 more
doaj   +1 more source

Influence of adhesins on the interaction of Escherichia coli with human phagocytes [PDF]

Infection and Immunity, 1984
The fitness between bacterial adhesins and target cell receptors, determining bacterial adherence to epithelial cells in urinary tract infections, was shown to influence also the interaction with human polymorphonuclear leukocytes (PMNL). Two sets of homogenic strains, constructed to express either, both, or none of the globotetraosylceramide-sensitive
C, Svanborg Edén, L M, Bjursten, R, Hull, S, Hull, K E, Magnusson, Z, Moldovano, H, Leffler   +6 more
openaire   +2 more sources

Differential Afa/Dr Fimbriae Expression in the Multidrug-Resistant Escherichia coli ST131 Clone

mBio, 2022
Many antibiotic resistant uropathogenic Escherichia coli (UPEC) strains belong to clones defined by their multilocus sequence type (ST), with ST131 being the most dominant.
Laura Alvarez-Fraga, Minh-Duy Phan, Kelvin G. K. Goh, Nguyen Thi Khanh Nhu, Steven J. Hancock, Luke P. Allsopp, Kate M. Peters, Brian M. Forde, Leah W. Roberts, Matthew J. Sullivan, Makrina Totsika, Scott A. Beatson, Glen C. Ulett, Mark A. Schembri   +13 more
doaj   +1 more source

Characterization of the Adhesin of Escherichia coli F18 Fimbriae [PDF]

Infection and Immunity, 2001
ABSTRACT Previous research has suggested that the adhesin encoded by the F18 fimbrial operon in Escherichia coli is either the FedE or FedF protein. In this work, we show that anti-FedF antibodies, unlike anti-FedE serum, were able to inhibit E. coli adhesion to porcine enterocytes.
A, Smeds, K, Hemmann, M, Jakava-Viljanen, S, Pelkonen, H, Imberechts, A, Palva   +5 more
openaire   +2 more sources

Genotypic characterization of virulence factors in Escherichia coli strains from patients with cystitis Caracterização genotípica dos fatores de virulência em amostras de Escherichia coli isoladas de pacientes com cistite

Revista do Instituto de Medicina Tropical de São Paulo, 2008
Adhesins (P-fimbriae, S-fimbriae, type 1 fimbriae and afimbrial adhesin), toxins (α-hemolysin and cytotoxic necrotizing factor type 1), iron acquisition systems (aerobactin) and host defense avoidance mechanisms (capsule or lipopolysaccharide) have ...
Monique Ribeiro Tiba, Tomomasa Yano, Domingos da Silva Leite   +2 more
doaj   +1 more source

Identification of Coli Surface Antigen 23, a Novel Adhesin of Enterotoxigenic Escherichia coli [PDF]

Infection and Immunity, 2012
ABSTRACT Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea, mainly in developing countries. Although there are 25 different ETEC adhesins described in strains affecting humans, between 15% and 50% of the clinical isolates from different geographical regions are negative for these ...
Del Canto, Felipe, Botkin, Douglas J., Valenzuela, Patricio, Popov, Vsevolod, Ruiz-Perez, Fernando, Nataro, James P., Levine, Myron M., Stine, O. Colin, Pop, Mihai, Torres, Alfredo G., Vidal, Roberto   +10 more
openaire   +5 more sources

Autotransporter Adhesins in Escherichia coli Pathogenesis

PROTEOMICS, 2017
AbstractMost bacteria produce adhesion molecules to facilitate the interaction with host cells and establish successful infections. An important group of bacterial adhesins belong to the autotransporter (AT) superfamily, the largest group of secreted and outer membrane proteins in Gram‐negative bacteria.
Julieanne L, Vo, Gabriela Constanza, Martínez Ortiz, Pramod, Subedi, Shivakumar, Keerthikumar, Suresh, Mathivanan, Jason J, Paxman, Begoña, Heras   +6 more
openaire   +3 more sources