Results 61 to 70 of about 1,357,755 (309)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1

Communications Biology, 2023
Scribble (Scrib) is a multidomain polarity protein and member of the leucine-rich repeat and PDZ domain (LAP) protein family. A loss of Scrib expression is associated with disturbed apical-basal polarity and tumor formation.
Eva-Maria Thüring, Christian Hartmann, Janesha C. Maddumage, Airah Javorsky, Birgitta E. Michels, Volker Gerke, Lawrence Banks, Patrick O. Humbert, Marc Kvansakul, Klaus Ebnet   +9 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Unraveling T-cell decoding strategy: a step forward

The EMBO Journal
Elucidation of the mechanisms by which T-cells discriminate between self and foreign antigens has been a major challenge in immunology. In this issue of The EMBO Journal, Huhn and colleagues (Huhn et al, 2025) show that the affinity between soluble ...
Philippe Robert, Pierre Bongrand
doaj   +1 more source

Depth profile of thin coating through surface and interfacial cutting analysis of UV curing system

Materials & Design, 2019
There are various thin coating technologies, among which the UV coating technology is attracting attention in next-generation industries. In order to utilize the UV coating system stably, it is necessary to analyze and address the problems of surface ...
Ji-Won Park, Kyeng-Bo Sim, Gyu-Seong Shim, Jong-Ho Back, Dooyoung Baek, Hyun-Joong Kim, Seunghan Shin   +6 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Chemoresistance induces enhanced adhesion and transendothelial penetration of neuroblastoma cells by down-regulating NCAM surface expression. [PDF]

, 2006
It is concluded that NB cells resistant to anticancer drugs acquire increased invasive capacity relative to non-resistant parental cells, and that enhanced invasion is caused by strong down-regulation of NCAM adhesion ...
Michaelis, Martin, Cinatl, Jindrich, Daher, Frederick H, Martin Michaelis, Daher, Frederick H., Hasenberg, Christoph, Weich, Eva M., Doerr, Hans Wilhelm, Roman A Blaheta, Rouslan Kotchetkov, Dietger Jonas, Blaheta, Roman A., Weich, Eva M, Christoph Hasenberg, Jindrich Cinatl, Kotchetkov, Rouslan, Jonas, Dietger, Eva M Weich, Hans Willhelm Doerr, Frederick H Daher   +19 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Carbohydrate–carbohydrate interaction provides adhesion force and specificity for cellular recognition [PDF]

, 2004
© 2004 Bucior et al. This article is distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. The definitive version was published in Journal of Cell Biology 165 (2004): 529-537, doi:10.1083/jcb ...
Bucior, Iwona, Engel, A., Scheuring, Simon, Simon Scheuring, Burger, Max M., Burger, M. M., Scheuring, S., Iwona Bucior, Bucior, I., Max M. Burger, Andreas Engel, Engel, Andreas   +11 more
core   +1 more source