Results 61 to 70 of about 1,904,554 (255)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown [PDF]

, 2010
Background: An inducible release of soluble junctional adhesion molecule-A (sJAM-A) under pro-inflammatory conditions was described in cultured non-CNS endothelial cells (EC) and increased sJAM-A serum levels were found to indicate inflammation in non ...
Romero, Ignacio, Deiß Annika, Deiß, Annika, Buttmann, Mathias, Weksler Babette, Rieckmann, Peter, Ignacio Romero, Mathias Buttmann, Prochaska, Jürgen, Couraud, Pierre-Olivier, Jürgen Prochaska, Haarmann, Axel, Peter Rieckmann, Buttmann Mathias, Weksler, Babette, Axel Haarmann, Stoll, Guido, Najbauer, Joseph, Pierre-Olivier Couraud, Annika Deiss, Couraud Pierre-Olivier, Prochaska, Juergen, Stoll Guido, Guido Stoll, Förch, Christian, Romero Ignacio, Foerch, Christian, Prochaska Jürgen, Christian Foerch, Rieckmann Peter, Babette Weksler, Foerch Christian, Haarmann Axel   +32 more
core   +1 more source

Evaluation of serum levels of cell adhesion molecules (ICAM-1) and vascular adhesion molecules (VCAM-1) following a resistance training program in middle-aged and elderly men with hypertension [PDF]

مجله علوم پزشکی فیض (پیوسته)
Background and Aim: Cell adhesion molecules (ICAM-1) and vascular adhesion molecules (VCAM-1) play critical roles in endothelial function and cardiovascular diseases.
Bizhan Hooshmand Moghadam, Shadi Moazamigoudarzi, Amir Rashidlamir, Babak Hooshmand-Moghadam   +3 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. [PDF]

, 2012
During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits.
Carmen Grijota-Martinez (152374), Luis Garcia-Alonso, Sigrid Baars (152383), Cabedo, H, Emanuelle Donier, Carmen Grijota-Martinez, Gomez-Sanchez, JA, Lakomá, J, Emanuelle Donier (152367), Garcia-Alonso, L, Jose Antonio Gomez-Sanchez (152369), Jarmila Lakomá, Donier, E, Jarmila Lakomá (152379), Luis Garcia-Alonso (152388), Grijota-Martinez, C, Baars, S, Hugo Cabedo, Jose Antonio Gomez-Sanchez, Hugo Cabedo (152396), Sigrid Baars   +20 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus [PDF]

, 2012
The junctional adhesion molecule (JAM)-C is a widely expressed adhesion molecule regulating cell adhesion, cell polarity and inflammation. JAM-C expression and function in the central nervous system (CNS) has been poorly characterized to date.
Michel Mittelbronn, Imhof, Beat A., Aurrand-Lions, Michel, Michel Aurrand-Lions, Deutsch, Urban, Karl H Plate, Adams, Ralf H, Liebner, Stefan, Schäfer, Julia, Enzmann, Gaby, Plate, Karl H, Urban Deutsch, Beat A Imhof, Adams, Ralf Heinrich, Mittelbronn, Michel, Imhof, Beat, Mittelbronn, Michel Guy André, Plate, Karl, Gaby Enzmann, Ralf H Adams, Engelhardt, Britta, Britta Engelhardt, Lena Wyss, Stefan Liebner, Plate, Karl H., Julia Schäfer, Wyss, Lena, Adams, Ralf H.   +27 more
core   +3 more sources

Cell adhesion molecules and exercise

Journal of Inflammation Research, 2018
Yunsuk Koh,1 Jinkyung Park2 1Department of Health, Human Performance, and Recreation, Baylor University, Waco, TX, USA; 2Department of Kinesiology, George Mason University, Manassas, VA, USA Background: An extensive systematic review was undertaken in ...
Koh Y, Park J
doaj  

Synaptic Cell Adhesion Molecules in Alzheimer’s Disease

Neural Plasticity, 2016
Alzheimer’s disease (AD) is a neurodegenerative brain disorder associated with the loss of synapses between neurons in the brain. Synaptic cell adhesion molecules are cell surface glycoproteins which are expressed at the synaptic plasma membranes of ...
Iryna Leshchyns’ka, Vladimir Sytnyk
doaj   +1 more source

Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection

Cells, 2018
Junctional adhesion molecules (JAMs) are cell surface adhesion receptors of the immunoglobulin superfamily. JAMs are involved in a variety of biological processes both in the adult organism but also during development.
Daniel Kummer, Klaus Ebnet
doaj   +1 more source