Results 81 to 90 of about 1,904,554 (255)

Adhesion molecules in dementia

, 2016
During the past decade it has become evident that immunological, infl ammatory and vascular processes play an important role in the etiology and pathogenesis of various neuro-degenerative diseases.
Jianping, Jia,, Yong-Xin, Sun,, Janciauskiene, Sabina,, Lund University.   +3 more
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Expression of adhesion molecules in leprosy lesions. [PDF]

, 1991
Leprosy presents as a clinical spectrum that is precisely paralleled by a spectrum of immunological reactivity. The disease provides a useful and accessible model, in this case in the skin, in which to study the dynamics of cellular immune responses to ...
Hofman, F, Modlin, R L, Mueller, C, Bloom, B R, Sullivan, L, Pirmez, C, Sano, S, Uyemura, K, Rea, T H, Salgame, P   +9 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Carbamylated low-density lipoprotein and adhesion molecules

, 2016
Carbamylated LDL (cLDL), the most abundant modifi ed LDL isoform in human blood, has been recently implicated in causing atherosclerosis-prone injuries to endothelial cells in vitro and atherosclerosis in patients with chronic kidney disease.
Basnakian A.G., Ok E., Apostolov E.O., Shah S.V.   +3 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Mycophenolate mofetil modulates adhesion receptors of the beta I integrin family on tumor cells: impact on tumor recurrence and malignancy [PDF]

, 2005
Background: Tumor development remains one of the major obstacles following organ transplantation. Immunosuppressive drugs such as cyclosporine and tacrolimus directly contribute to enhanced malignancy, whereas the influence of the novel compound ...
Natsheh Iyad, Blaheta Roman A, Müller Iris, Makarević Jasmina, Natsheh, Iyad Y. M., Müller, Iris, Beecken Wolf-Dietrich, Engl Tobias, Jonas Dietger, Jasmina Makarević, Wolf-Dietrich Beecken, Beecken, Wolf-Dietrich, Iris Müller, Relja Borna, Roman A Blaheta, Dietger Jonas, Blaheta, Roman A., Makarević, Jasmina, Tobias Engl, Iyad Natsheh, Jonas, Dietger, Borna Relja, Relja, Borna, Engl, Tobias A.   +23 more
core   +2 more sources

Upregulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in renal tissue in severe dengue in humans: Effects on endothelial activation/dysfunction

Revista da Sociedade Brasileira de Medicina Tropical, 2019
INTRODUCTION: Dengue is an important mosquito-borne disease in tropical and subtropical regions. Adhesion molecules have not been systematically characterized in the renal tissue of patients with severe dengue (SD).
Webster Oliveira Vitoria, Letícia Silva Thomé, Luciane Kanashiro-Galo, Leda Viegas de Carvalho, Ricardo Penny, Washington Luis Conrado Santos, Pedro Fernando da Costa Vasconcelos, Mirian Nacagami Sotto, Maria Irma Seixas Duarte, Juarez Antonio Simões Quaresma, Carla Pagliari   +10 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

ACE-inhibition prevents postischemic coronary leukocyte adhesion and leukocyte-dependent reperfusion injury [PDF]

, 1997
Objective: Polymorphonuclear leukocytes (PMN), retained in the microvascular bed, can contribute to postischemic myocardial reperfusion injury. Since a beneficial effect of ACE-inhibition on reperfusion injury has been reported, we investigated the ...
Weber, Christian, Messmer, Konrad, Habazettl, Helmut, Kupatt, Christian, Gerlach, Eckehart, Zahler, Stefan, Becker, Bernhard F., C Kupatt   +7 more
core   +1 more source