Results 41 to 50 of about 119,088 (108)
, 2020 IC50 curves for ADI-PEG20 in ovarian cancer cell lines. A, ASS1-deficient ovarian cancer cell lines and B, ASS1-proficient ovarian cancer cell lines.
Dawn R. Cochrane (14917856) +23 more
core +1 more source
Advanced Science, Volume 13, Issue 58, 19 October 2026.This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang +5 more
wiley +1 more source
Amino Acid Metabolism in Health and Disease
MedComm, Volume 7, Issue 9, September 2026.This graphical abstract delineates the multifaceted role of amino acid metabolism in health and disease. It illustrates how amino acids sustain physiological homeostasis across the liver, kidney, brain, heart, intestine, muscle, skeleton, and immune system.
Zhiwei Su +7 more
wiley +1 more source
Abstract 5569: The impact of ADI-PEG20 on PDL1 expression in ASS1 deficient uveal melanoma
, 2017 Uveal melanoma (UM), involving the iris, choroid and ciliary body, is the commonest intraocular tumor in adults. Half of patients develop metastasis with a high mortality despite currently available systemic therapies including immune checkpoint blockade.
Peter W. Szlosarek +5 more
core +1 more source
Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma. [PDF]
, 2012 Arginine deprivation, either by nutritional starvation or exposure to ADI-PEG20, induces adaptive transcriptional upregulation of ASS1 and ASL in glioblastoma multiforme ex vivo cultures and cell lines.
O'Neil, K +14 more
core +2 more sources
Cancer Medicine, Volume 14, Issue 21, November 2025.ABSTRACT Background Lung cancer remains the leading cause of cancer‐related mortality worldwide. Although immunotherapy has revolutionized lung cancer treatment, its efficacy is often hindered by primary and acquired immune resistance. Increasing evidence indicates that metabolic reprogramming plays a crucial role in tumor progression and the ...
Yi Chen +8 more
wiley +1 more source
Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect
Molecular & Cellular Oncology, 2017 Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously ...
Jeff C. Kremer, Brian A. Van Tine
doaj +1 more source
Telomere–metabolism–immunity axis in sarcoma: Immune evasion mechanisms and therapeutic strategies
Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.Telomere maintenance mechanisms (telomerase reverse transcriptase and alternative lengthening of telomeres) reprogram metabolism and dampen innate immune sensing in sarcomas. Metabolic rewiring (glutamine addiction, glycolysis and fatty acid oxidation) fosters T‐cell dysfunction and myeloid‐derived suppressor cell accumulation.
Ji‐Yong Sung, June Hyuk Kim
wiley +1 more source
Arginine Deprivation in SCLC: Mechanisms and Perspectives for Therapy
Lung Cancer: Targets and Therapy, 2022 Joséphine Carpentier,1 Iuliia Pavlyk,1 Uma Mukherjee,2 Peter E Hall,2 Peter W Szlosarek1,2 1Centre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK; 2Department of Medical Oncology ...
Carpentier J +4 more
doaj
Pediatric Blood &Cancer, Volume 72, Issue 10, October 2025.ABSTRACT Outcomes for relapsed Ewing sarcoma remain consistently poor. Continued efforts to consider creative new approaches for the treatment of relapsed Ewing sarcoma are needed. The Children's Oncology Group Bone Tumor Committee convened a New Strategies for Ewing Sarcoma Task Force to systematically evaluate agents for inclusion in future Phase II ...
Jessica D. Daley +17 more
wiley +1 more source