Results 51 to 60 of about 119,088 (108)
Interdisciplinary Medicine, Volume 3, Issue 3, May 2025.Left: The disruption of the balance between carcinogenic bacteria and probiotics mediated by antibiotics, protein, and glucose intake. Middle: The gut microbiota‐derived amino acids, primarily through tryptophan, tyrosine, arginine, and branched‐chain amino acid pathways, regulate glioma development via mechanisms such as AHR activation, metabolic ...
Qianquan Ma +10 more
wiley +1 more source
, 2010 Various tumor types have been shown to lack expression of the enzyme argininosuccinate synthase (ASS) that is required for the synthesis of arginine and thus rely on exogenous sources for protein synthesis requirements.
Lloyd J. Old +5 more
core +1 more source
Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes [PDF]
, 2010 It has been shown that a subset of human cancers, notably, melanoma and hepatocellular carcinoma (HCC) are auxotrophic for arginine (Arg), because they do not express argininosuccinate synthetase (ASS), the rate-limiting enzyme for the biosynthesis of ...
Savaraj, Niramol +2 more
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Journal of Immunology Research, Volume 2025, Issue 1, 2025.Amino acid metabolism in T cells determines the therapeutic efficacy of T‐cell‐targeting drugs. To assess the direction of amino acid metabolism in T cells and construct related knowledge structure, we performed a bibliometric analysis aiming at amino acid metabolism in T cells utilizing studies publicized in recent 15 years. Three hundred thirty‐seven
Jiaona Xu +4 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +2 more sources
The role of the tumour microenvironment in arginine deprivation in malignant pleural mesothelioma [PDF]
, 2017 PhDApproximately 50% of all malignant pleural mesotheliomas (MPM) are deficient in argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine biosynthesis, and are sensitive to arginine deprivation.
Phillips, Melissa
core +1 more source
, 2013 Figure-S2 PDF file 129K, Figure-S2 ADI-PEG20 treatment in myxofibrosarcoma cell lines and xenografts: (A) Pharmacokinetic curve of ADI-PEG20 demonstrates its dose-dependent capability in deprivation of arginine in culture medium of OH931 cells within the
Fu-Min Fang (502561) +13 more
core +1 more source
Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin [PDF]
, 2015 Loss of argininosuccinate synthetase (ASS) expression in melanoma makes these tumor cells vulnerable to arginine deprivation. Pegylated arginine deiminase (ADI-PEG20) which degrades arginine to citrulline and ammonia has been used clinically and partial ...
Wangpaichitr, Medhi +8 more
core +1 more source
Amino Acid Uptake Measured by [18F]AFETP Increases in Response to Arginine Starvation in ASS1-Deficient Sarcomas [PDF]
, 2018 Rational: In a subset of cancers, arginine auxotrophy occurs due to the loss of expression of argininosuccinate synthetase 1 (ASS1). This loss of ASS1 expression makes cancers sensitive to arginine starvation that is induced by PEGylated arginine ...
Jinbin Xu +20 more
core +1 more source
Phase II study of pegylated arginine deiminase (ADI-PEG20), a novel targeted therapy for melanoma
, 2006 8045 Background: Melanoma cells may be sensitive to arginine (Arg) deprivation due to lack of expression of argininosuccinate synthetase (ASS) which is needed to synthesize Arg, a nonessential amino acid in humans, from citrulline (Ctr). ADI-PEG20 lowers
Herrera, C. +9 more
core +1 more source