Results 71 to 80 of about 119,088 (108)

Pegylated arginine deiminase (ADI-PEG20) in relapsed/refractory and/or elder Acute Myeloid Leukemia: The preliminary result of phase II trial

, 2015
[[abstract]]Background: Deprivation of circulating L-asparagine by L-asparaginase, which can lead to the inhibition of RNA and DNA synthesis and subsequent apoptosis of blastic cell, has been implemented as part of multidrug chemotherapy for acute ...
Tsai, HJ;Wang, MC;Lin, SF;Chen, YP;Hsiao, HH;Kuo, CY;Chen, LT;Chen, TY
core  

Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells

, 2012
Melanomas and other cancers that do not express argininosuccinate synthetase (AS), the rate-limiting enzyme for arginine biosynthesis, are sensitive to arginine depletion with pegylated arginine deiminase (ADI-PEG20).
Tsai, Wen-Bin, Lin, Hui-Kuan, Feun, Lynn, Savaraj, Niramol, Long, Yan, Aiba, Isamu, Kuo, Macus Tien   +6 more
core   +1 more source

Arginine deiminase: A novel radiosensitizer in pancreatic cancer in vitro and in vivo.

, 2014
221 Background: The benefits of chemoradiation therapy in patients with locally advanced pancreatic cancer (LAPC) are limited due to the inherent radioresistance of pancreatic cancer (PC) and high systemic toxicity of current radiosensitizers (e.g ...
Sunil Krishnan, Parmeswaran Diagaradjane, John S. Bomalaski, Amit Deorukhkar, Dev Chatterjee, Nga Diep   +5 more
core   +1 more source

Combination of arginine deprivation with TRAIL treatment as a targeted-therapy for mesothelioma

, 2014
In the present study we present data to show that certain tumor cells including malignant pleural mesothelioma (MPM) cells do not express argininosuccinate synthetase (ASS), and thus are unable to synthesize arginine from citrulline.
Bigford, Gregory, Li, Ying Ying, Wangpaichitr, Medhi, You, Min, Verona-Santos, Javier, Theodoropoulos, George, Feun, Lynn G, Savaraj, Niramol, Nguyen, Dao M, Wu, Chunjing   +9 more
core   +2 more sources

The Combined Therapeutic Effect of Lenvatinib and ADI-PEG 20 in Advanced Hepatocellular Carcinoma: A Case Report. [PDF]

In Vivo
Yu J, Lin YH, Yeh CT, Lin CL.
europepmc   +1 more source

Decoding amino acid metabolism in hepatocellular carcinoma: critical nodes and novel therapeutic strategy. [PDF]

Front Oncol
Zhang J, Zhu Y, Liu G, Liao M, Wu J, Chen C, Guo M, Jiang Y, Zhao J, Xu L.   +9 more
europepmc   +1 more source

Targeting the amino acid metabolic axis: the Achilles' heel of tumor cells. [PDF]

Amino Acids
Hu Z, Wang Y, Ma Q.
europepmc   +1 more source

Arginine Deprivation of ASS1-Deficient Cancers Drives Mistranslation and Shared Neoepitope Production. [PDF]

Cancer Res
Nagel R, Kochavi A, Flem-Karlsen K, Adhikary M, Gal-On Y, Klaoudatou MG, Champagne J, Valcanover L, Palashati H, Nielsen MM, Feng X, Körner PR, Giebel L, Yang W, Velds A, Hoekman L, Bleijerveld OB, van Tellingen O, Olweus J, Agami R.   +19 more
europepmc   +1 more source

Molecular mechanisms and therapies for tumor inhibition through the arginine metabolism pathway. [PDF]

Front Oncol
Xu Y, Yu M, Zhang Y, Jiang Y, Zhu H, He S, Yu G, Li N, Liu S, Liu B.   +9 more
europepmc   +1 more source