Results 101 to 110 of about 946,668 (293)

Humic Acid Extracted from Blackfoot Disesse-Endemic Well Water Induced Adipocyte Differentiation of C3h10t 1/2 Fibroblast Cells: A Possible Mechanison Leading to Atherosclerotic-Like Plaque in Blackfoot Disease

, 2009
A unique peripheral vascular disease named "Blackfoot disease" (BFD) is endemic on the southwest coast of Taiwan. Clinically, the signs and symptoms of BFD are similar to those of arteriosclerosis and Buerger disease.
黃天祥, HUANG, TIEN-SHANG
core  

Like galectin-12, VPS13C is required for adipocyte differentiation.

, 2016
3T3-L1 cells were stably transduced with a doxycycline-inducible conditional knockdown system for LacZ (control), galectin-12, or Vps13c. Cells were then stimulated to undergo adipocyte differentiation following an established regimen for 10 days, in the
Antonio Velayos-Baeza (2609665), Fu-Tong Liu (30764), Lan Yu (346201), Ri-Yao Yang (2609668), Anthony P. Monaco (184852), Huiting Xue (108679)   +5 more
core   +1 more source

DeepLNM: A Multimodal Model for Predicting Lymph Node Metastasis in Colorectal Cancer

Advanced Science, EarlyView.
Traditional diagnosis may miss positive LNM cases, and pathologists face a workload; therefore, we develop DeepLNM, a multimodal model that predicts lymph node metastasis in colorectal cancer from H&E WSIs, CT images, and text. DeepLNM is robust across internal, external, and prospective cohorts and, in a user study, improves diagnostic accuracy while ...
Zhengyu Zhang, Chengyu Lu, Zhen Wang, Zhijian Cen, Yangshu Zhou, Danyi Li, Qi Xie, Bingbing Li, Shujing Guo, Zhijun Gan, Er‐ran Zhu, Jinbang Li, Aihetaimu Aimaier, Rui Mao, Weihao Qiu, Chenglong Zhao, Ying Tan, Xiaolin Liu, Huiting Ma, Tiansu Geng, Peiyue Wu, Huijun Du, Yu Wang, Yueping Liu, Li Liang   +24 more
wiley   +1 more source

TRB3 suppresses adipocyte differentiation by negatively regulating PPARγ transcriptional activitys⃞

Journal of Lipid Research, 2008
In the course of an effort to identify the regulators for peroxisome proliferator-activated receptor γ (PPARγ)-dependent perilipin gene expression, we found that tribbles homolog 3 (TRB3), containing a single kinase domain without enzymatic activity ...
Yu Takahashi, Nobumichi Ohoka, Hidetoshi Hayashi, Ryuichiro Sato   +3 more
doaj   +1 more source

p38MAP Kinase activity is required for human primary adipocyte differentiation.

, 2007
International audienceLittle is known about the role of p38MAPK in human adipocyte differentiation. Here we showed that p38MAPK activity increases during human preadipocytes differentiation.
Laurent, Kathiane, M. Cormont, Tanti, Jean-François, B. Binétruy, Binétruy, Bernard, M. Aouadi, T. Gonzalez, Y. Le Marchand-Brustel, F. Bost, Jager, Jennifer, K. Laurent, J.-F. Tanti, Cormont, Mireille, Le Marchand Brustel, Yannick, J. Jager, Bost, Frédéric, Gonzalez, Teresa, Aouadi, Myriam   +17 more
core   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Wnt4 and Wnt5a promote adipocyte differentiation

FEBS Letters, 2008
The roles of the non‐canonical Wnt pathway during adipogenesis are not well known, though Wnt10b is known to function as a negative regulator for adipogenesis by activating the canonical Wnt pathway. We focused on the roles of Wnt4, Wnt5a and Wnt6, which are thought to be part of the non‐canonical Wnt pathway.
Nishizuka, Makoto, Koyanagi, Akiko, Osada, Shigehiro, Imagawa, Masayoshi   +3 more
openaire   +2 more sources

Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype. Biochim Biophys Acta.

, 2016
Adipocyte differentiation is critical in obesity. By controlling new adipocyte recruitment, adipogenesis contrasts adipocyte hypertrophy and its adverse consequences, such as insulin resistance. Contrasting data are present in literature on the effect of
Zatterale F, Beguinot F, Longo M, D'Esposito V, Formisano P, Raciti GA, Di Jeso B, Fiory F, Miele C, Spinelli R, Nigro C   +10 more
core   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Neuron-derived neurotrophic factor promotes the differentiation of intramuscular and subcutaneous adipocytes in goat

Animal Biotechnology
Adipocyte play an important role in human health and meat quality by influencing the tenderness, flavor, and juiciness of mutton It has been shown that neuron-derived neurotrophic factor (NENF) is closely related to energy metabolism and adipocyte ...
An Li, Youli Wang, Ruiwen Li, Yaqiu Lin, Yanyan Li, Yong Wang, Wei Liu, Xiong Yan   +7 more
doaj   +1 more source