Results 101 to 110 of about 118,942 (299)

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Differential Patterns of Secreted Frizzled-Related Protein 4 (SFRP4) in Adipocyte Differentiation: Adipose Depot Specificity

Cellular Physiology and Biochemistry, 2018
Background/Aims: Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that acts as soluble modulators of Wnt signaling. Given the substantial rise in obesity, depot-specific fat accumulation and its associated diseases like diabetes,
Hua Guan, Yali Zhang, Shoucui Gao, Liang Bai, Sihai Zhao, Xian Wu Cheng, Jianglin Fan, Enqi  Liu   +7 more
doaj   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

TRB3 suppresses adipocyte differentiation by negatively regulating PPARγ transcriptional activitys⃞

Journal of Lipid Research, 2008
In the course of an effort to identify the regulators for peroxisome proliferator-activated receptor γ (PPARγ)-dependent perilipin gene expression, we found that tribbles homolog 3 (TRB3), containing a single kinase domain without enzymatic activity ...
Yu Takahashi, Nobumichi Ohoka, Hidetoshi Hayashi, Ryuichiro Sato   +3 more
doaj   +1 more source

Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation [PDF]

, 2013
Previous studies have shown that exogenous ATP (>1µM) prevents bone formation in vitro by blocking mineralisation of the collagenous matrix. This effect is thought to be mediated via both P2 receptor-dependent pathways and a receptor-independent ...
A Brandao-Burch, A Brandao-Burch, A Gartland, A Hoebertz, BA Evans, CG Bellows, DC Genetos, DC Genetos, E Nakamura, G Burnstock, G Burnstock, G Burnstock, G Burnstock, H Fleisch, H Fleisch, H Zimmermann, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, Isabel R. Orriss, J Ham, JL Ramírez-Zacarías, JP Reyes, KA Buckley, KA Buckley, KA Johnson, L Hessle, Luc Malaval, M Ciciarello, M Romanello, Mark O. R. Hajjawi, Michelle L. Key, MP Abbracchio, MW Pfaffl, N Panupinthu, N Panupinthu, N Wang, N Zippel, RM Rumney, S Shimegi, S Syberg, Timothy R. Arnett, V Ralevic, WB Bowler, WE Razzell, WN Addison   +49 more
core   +3 more sources

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Functional Implications of DNA Methylation in Adipose Biology. [PDF]

, 2019
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role ...
Kang, Sona, Ma, Xiang
core  

Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress [PDF]

, 2018
Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity.We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (HO- 1)
Abraham, Nader G., Bamshad, David, Bellner, Lars, Favero, Gaia, Grant, Ilana, Lebovics, Edward, Meissner, Aliza, Raffaele, Marco, Rezzani, Rita, Rodella, Luigi F., Sacerdoti, David, Schragenheim, Joseph, Singh, Shailendra P., Vanella, Luca   +13 more
core   +1 more source

Coupling Growth Arrest and Adipocyte Differentiation

Environmental Health Perspectives, 1989
The complete differentiation program of preadipose cells can be divided into early and late events. The expression of early markers takes place at growth arrest (G1/S boundary), whereas that of late markers, leading to terminal differentiation, takes place after a limited number of mitoses of early marker-containing cells. Only terminal differentiation
G, Ailhaud, C, Dani, E Z, Amri, P, Djian, C, Vannier, A, Doglio, C, Forest, D, Gaillard, R, Négrel, P, Grimaldi   +9 more
openaire   +2 more sources