Results 181 to 190 of about 39,170 (208)

Isolation and Characterization of Human Brown Adipocytes

2022
Brown adipose tissue (BAT) is a thermoregulatory fat with energy-consuming properties. The location and heterogeneity of this tissue makes it complicated to sample before and after interventions in humans, and an in vitro model for mechanistic and molecular studies is therefore of great value.
Scheele, Camilla, Henriksen, Tora Ida, Nielsen, Søren   +2 more
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Determinants of brown adipocyte development and thermogenesis

International Journal of Obesity, 2010
The brown adipocyte is a thermogenic cell. Its thermogenic potential is conferred by uncoupling protein-1, which 'uncouples' adenosine triphosphate synthesis from energy substrate oxidation. Brown fat cells in so-called classical brown adipose tissue (BAT) share their origin with myogenic factor-5-expressing myoblasts.
D, Richard, A C, Carpentier, G, Doré, V, Ouellet, F, Picard   +4 more
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MicroRNAs involved in the browning process of adipocytes

Journal of Physiology and Biochemistry, 2015
The present review focuses on the role of miRNAs in the control of white adipose tissue browning, a process which describes the recruitment of adipocytes showing features of brown adipocytes in white adipose tissue. MicroRNAs (miRNAs) are a class of short non-coding RNAs (19-22 nucleotides) involved in gene regulation.
N, Arias, L, Aguirre, A, Fernández-Quintela, M, González, A, Lasa, J, Miranda, M T, Macarulla, M P, Portillo   +7 more
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Genetic Studies of Brown Adipocyte Induction

The Journal of Nutrition, 2000
We seek to discover an effective method for utilizing thermogenesis to reduce the caloric load in obese individuals. Experimental evidence indicates that nonshivering thermogenesis is the most effective cellular and biochemical mechanism known for reducing excessive adiposity. In this presentation, we describe our experiments aimed at understanding how
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Trans-anethole ameliorates obesity via induction of browning in white adipocytes and activation of brown adipocytes

Biochimie, 2018
To treat obesity, suppression of white adipose tissue (WAT) expansion and activation of brown adipose tissue (BAT) are considered as potential therapeutic targets. Recent advances have been made in the induction of brown fat-like adipocytes (beige) in WAT, which represents an attractive potential strategy for the management and treatment of obesity ...
Nam Hyeon, Kang, Sulagna, Mukherjee, Taesun, Min, Sun Chul, Kang, Jong Won, Yun   +4 more
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Functional differentiation of white and brown adipocytes

BioEssays, 1997
AbstractAdipose tissue plays an important role in mammalian energy equilibrium not only as a lipid‐dissipating, i.e. energy‐storing, tissue (white adipose tissue), but also as an energy‐dissipating one (brown adipose tissue). Brown adipocytes have the ability of facultative heat production due to a unique mitochondrial protein, the uncoupling protein ...
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Succinate Oxidation in Hamster Brown Adipocytes

1978
In a suspension of isolated hamster brown adipocytes succinate can be oxidized at a high rate. This oxidation capacity is found to be mainly extracellular and can be totally blocked by the SH-reagent DTNB. In the intact cell succinate is found to be oxidized very slow probably as a function of a low transport rate over the membrane(s).
B, Pettersson, P, Lundberg, V S, Bernson
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Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes

Cell Biochemistry and Function, 2016
The ingestion of capsaicin, the principle pungent component of red and chili peppers, induces thermogenesis, in part, through the activation of brown adipocytes expressing genes related to mitochondrial biogenesis and uncoupling such as peroxisome proliferator‐activated receptor (Ppar) γ coactivator‐1α (Pgc‐1α) and uncoupling protein 1 (Ucp1 ...
Ryosuke, Kida, Hirofumi, Yoshida, Masaru, Murakami, Mitsuyuki, Shirai, Osamu, Hashimoto, Teruo, Kawada, Tohru, Matsui, Masayuki, Funaba   +7 more
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Huang-Qi San ameliorates hyperlipidemia with obesity rats via activating brown adipocytes and converting white adipocytes into brown-like adipocytes

Phytomedicine, 2020
Brown adipose tissue (BAT) activation is a promising therapeutic target to treat hyperlipidemia with obesity. Huang-Qi San (HQS), an traditional Chinese medicine, can ameliorate hyperlipidemia with obesity, but its mechanism of action (MOA) is not understood.To articulate the MOA for HQS with animal models.The main chemical constituents of HQS were ...
Mengjiao Hao, Zhuoji Guan, Ying Gao, Juling Xing, Xinxin Zhou, Chunyi Wang, Jun Xu, Weimin Li   +7 more
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White adipocytes transdifferentiation into brown adipocytes induced by triiodothyronine

2008
The uncontrolled expansion of white adipose tissue (WAT) seen in obesity predisposes affected individuals to health complications. Another type of fat, brown adipose tissue (BAT) has an opposing physiological function because it allows dissipation instead of storage of energy.
A. Korac, M. Cakic-Milosevic, M. Ukropina, M. Grubic, K. Micunovic, V. Petrovic, B. Buzadzic, A. Jankovic, A. Vasilijevic, B. Korac   +9 more
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