Results 151 to 160 of about 173,125 (313)

Decoding adipocyte heterogeneity through single-nucleus transcriptomics unveils subtype-specific adipocytes orchestrate immunosuppressive niches in breast cancer. [PDF]

J Immunother Cancer
Tong Y, Wang Z, Qiao N, Huang R, Wu C, Wang H, Fei X, Shen K, Chen X.   +8 more
europepmc   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Canine bone marrow peri-adipocyte cells could therapeutically benefit acute spinal cord injury through migration and secretion of hepatocyte growth factor to inflammatory milieu

, 2022
Junyan Chen, Naoki Fujita, Tae Takeda, Wataru Hanyu, Hirohide Takatani, Takayuki Nakagawa, Ryohei Nishimura   +6 more
openalex   +2 more sources

New approaches to treating chronic obstructive pulmonary disease with Colla corii asini

Animal Models and Experimental Medicine, EarlyView.
Colla corii asini improves chronic obstructive pulmonary disease (COPD) treatment through anti‐inflammatory, antioxidant, immune‐modulatory, and lung‐nourishing effects, addressing current therapeutic challenges via multitarget mechanisms. Abstract Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability ...
Wenchao Zhang, Siman Sun, Xiaoyu Fan, Jiuming He, Qing Li, Hongtao Jin   +5 more
wiley   +1 more source

Dedifferentiation and metabolic reprogramming of human adipocytes in the tumor niche triggered by colorectal cancer cells. [PDF]

Biol Res
Pietraszek-Gremplewicz K, Olszańska J, Domagalski M, Tymińska A, Skoniecka A, Pikuła M, Nowak D.   +6 more
europepmc   +1 more source

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin. [PDF]

Signal Transduct Target Ther
Li J, Li Y, Zhou X, Yang S, Liu D, Wen H, Chen X, Duan C, Yu M, Zhang M, Tang B, Wang Y, Wang L, Wu Y.   +13 more
europepmc   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Adipocyte-mediated electrophysiological remodeling of human stem cell - derived cardiomyocytes [PDF]

Justin Morrissette‐McAlmon, William Ren Xu, Roald Teuben, Kenneth R. Boheler, Leslie Tung   +4 more
openalex   +1 more source

Patterns of interspecific variation in labial microarchitecture among anthropoid primates and the evolution of the hominin lips

The Anatomical Record, EarlyView.
Comparative histological and semi‐automated image analysis of primate lips: Masson's trichrome‐stained sagittal sections were segmented to quantify the connective tissue, adipose, and muscular components, enabling interspecific comparisons of labial architecture.
Liat Rotenstreich, Kfir Eliyahu, Nir Edery, Lior Moss, Saleem Eben Bari, Assaf Marom   +5 more
wiley   +1 more source