Microphysiological Solid Tumor Models in Hydrogel Beads for CAR T Cell Immunotherapy Evaluation
Advanced Science, EarlyView.The complex physical and biochemical barriers of the tumor microenvironment are major triggers of immune exclusion. Here, a 3D micrometastasis model is developed to mimic key microenvironmental cues, enabling in vitro evaluation of chimeric antigen receptor (CAR) T cell immunotherapy. Abstract Micrometastases are challenging to resect surgically and to
Xuan Peng +14 more
wiley +1 more source
Pharmacological Characterizations of Adrenergic Receptors in Human Adipocytes [PDF]
, 1981 Thomas W. Burns +8 more
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Advanced Science, EarlyView.In this study, a comprehensive single‐cell transcriptome atlas of river and swamp buffalo, encompassing 12 tissues and 397,011 cells, is constructed. Differential expression analyses identify metabolic and secretory tissues and cell types that mediate the divergence of milk production.
Dongmei Dai +13 more
wiley +1 more source
Transcriptional control of brown adipocyte differentiation and function by NFIA: recent perspectives on deciphering metabolic diseases. [PDF]
J BiochemHiraike Y.
europepmc +1 more source
Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities
Advanced Science, EarlyView.The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley +1 more source
Adipocyte-derived IL6 and triple-negative breast cancer cell-derived CXCL1 co-activate STAT3/NF-κB pathway to mediate the crosstalk between adipocytes and triple-negative breast cancer cells. [PDF]
Cell Death DiscovRuan GT +6 more
europepmc +1 more source
Lipolytic response and adenyl cyclase activity of rat adipocytes as related to cell size
, 1971 Arthur D. Hartman +3 more
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Expression of a Glucose Transporter Gene Cloned from Brain in Cellular Models of Insulin Resistance: Dexamethasone Decreases Transporter mRNA in Primary Cultured Adipocytes [PDF]
, 1989 W. Timothy Garvey +3 more
openalex +1 more source
Advanced Science, EarlyView.Inhalable eugenol (EUG) from clove oil attenuates NAFLD by activating hepatic olfactory receptor Olfr544, triggering cAMP/PKA/CREB signaling to enhance lipolysis/oxidation. EUG concurrently restores gut microbiota, enriching probiotics (L. reuteri XR23/L. johnsonii XR25) and metabolites (IPA/5‐HIAA) that suppress lipogenesis.
Xiao‐Ran Wang +15 more
wiley +1 more source