Results 131 to 140 of about 60,035 (184)

In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells

Experimental Physiology, EarlyView.
Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene, Anita M. van den Hoek, Roeland Hanemaaijer, Lars Verschuren, Jelle C. B. C. de Jong   +4 more
wiley   +1 more source

Musculoskeletal decay and bone–muscle crosstalk during physical disuse: Mechanisms and integrated countermeasures

Experimental Physiology, EarlyView.
Abstract Older adults experience a markedly increased risk of falls and fractures following hospital discharge, largely due to the rapid musculoskeletal deterioration associated with bed rest. Although age‐related muscle and bone loss typically develops gradually, acute physical inactivity accelerates key biological processes underlying sarcopenia and ...
Julia Margarita Reyes, Guy Hajj‐Boutros, Dounia Rouabhia, José Morais, Felipe Salech, Gustavo Duque   +5 more
wiley   +1 more source

The pro-obesity role of G3BP1 through altering adipogenic differentiation in mice via the PI3K/AKT pathway. [PDF]

Adipocyte
Wang H, Sun L, Mao H, Mei Y, Ni J, Wang L.   +5 more
europepmc   +1 more source

Maternal obesity during lactation as a hypertensive cardiovascular risk factor in the offspring

Experimental Physiology, EarlyView.
Abstract Maternal obesity is a major public health concern, with growing evidence supporting its role in the developmental programming of cardiometabolic disease. Although prenatal mechanisms have been investigated extensively, the contribution of lactation as a postnatal window of cardiovascular (CV) programming remains insufficiently understood ...
Gabriela Arenas, Cristián A. Amador, Susana Contreras‐Duarte   +2 more
wiley   +1 more source

METTL14 Promotes Chicken Preadipocyte Differentiation by Modulating mRNA Stability via a Dual-Reader m⁶A Mechanism. [PDF]

Cells
Zhang S, Zhang Q, Yang Y, Liu C, Teng F, Wang S, Li H, Cheng B.   +7 more
europepmc   +1 more source

Circulating microRNA signatures reveal core and reversible dysregulation in obesity via machine learning

The Journal of Physiology, EarlyView.
Abstract figure legend Machine learning analysis of circulating microRNA (miRNA) profiles identified a minimal set of biomarkers that distinguish individuals with obesity from lean individuals both before and after weight‐loss intervention. Comparative analyses revealed heterogeneous molecular responses to weight reduction, with some miRNAs showing ...
Yuan Yue, Rajesh Katare, Jeremiah Deng, Daniel Alencar Da Costa, Patrick Manning   +4 more
wiley   +1 more source

Semi-automated, evidence-based workflow for selection of reference chemicals for the validation of NAMs: a case study with the adipogenesis assay. [PDF]

NAM J
Farnezi HCM, Lentz SBI, Legler J, Kamstra JH.   +3 more
europepmc   +1 more source

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source

<i>Larimichthys crocea</i>-Derived Calcium-Chelating Peptides Attenuate Leuprorelin-Induced Bone Loss and Lipid Metabolic Alterations in Mice. [PDF]

Mar Drugs
Wu X, Zheng S, Liu F, Liu J, Zhuang Y, Li D, Huang W.   +6 more
europepmc   +1 more source

Cox‐PASNet With Late Fusion of Transcriptomic and Clinical Features for Survival Prediction in Diffuse Large B‐Cell Lymphoma

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Accurate prognosis in diffuse large B‐cell lymphoma (DLBCL) remains a clinical challenge. The International Prognostic Index (IPI) is the standard tool but relies solely on clinical variables and fails to capture the extensive molecular heterogeneity of DLBCL.
Auguste Rumbutyte, Jonathan Pearson, Scarlett Kynoch   +2 more
wiley   +1 more source