Results 261 to 270 of about 28,208 (288)
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Adipokines, adiposity, and atherosclerosis
Cellular and Molecular Life Sciences, 2022Characterized by a surplus of whole-body adiposity, obesity is strongly associated with the prognosis of atherosclerosis, a hallmark of coronary artery disease (CAD) and the major contributor to cardiovascular disease (CVD) mortality. Adipose tissue serves a primary role as a lipid-storage organ, secreting cytokines known as adipokines that affect ...
Longhua, Liu +6 more
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Experimental Dermatology, 2011
Abstract: Adipose tissue is an active endocrine organ contributing to the regulation of multiple metabolic pathways via self‐produced bioactive products called adipokines. These adipokines are key players in the pathogenesis of metabolic syndrome and cardiovascular diseases.
Sascha, Gerdes +2 more
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Abstract: Adipose tissue is an active endocrine organ contributing to the regulation of multiple metabolic pathways via self‐produced bioactive products called adipokines. These adipokines are key players in the pathogenesis of metabolic syndrome and cardiovascular diseases.
Sascha, Gerdes +2 more
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Adipobiology of Disease: Adipokines and Adipokine-Targeted Pharmacology
Current Pharmaceutical Design, 2003In recent years, the simple paradigm of adipose tissue as merely a fat store is rapidly evolving into a complex paradigm of this tissue as multipotential secretory organ, partitioned into a few large depots, including visceral and subcutaneous location, and many small depots, associated with a variety of organs in the human body.
G N, Chaldakov +3 more
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Obesity, adipokines and neuroinflammation
Neuropharmacology, 2015Global levels of obesity are reaching epidemic proportions, leading to a dramatic increase in incidence of secondary diseases and the significant economic burden associated with their treatment. These comorbidities include diabetes, cardiovascular disease, and some psychopathologies, which have been linked to a low-grade inflammatory state.
Argel, Aguilar-Valles +3 more
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Adipose‐derived exosomes: A novel adipokine in obesity‐associated diabetes
Journal of Cellular Physiology, 2019Dysfunction of the adipose tissue is a central driver for obesity‐associated diabetes. It is characterized by dysregulated adipokine secretion, which contributes to insulin resistance of key metabolic tissues, including the liver, skeletal muscles, and ...
Bo Zhang +4 more
semanticscholar +1 more source
2008
Adipose tissue is the source of soluble mediators (adipokines), secreted mainly by adipocytes. Leptin acts on the brain and peripheral organs to regulate energy homeostasis and the neuroendocrine axis. Adiponectin regulates glucose and lipid metabolism by targeting the liver and skeletal muscle.
Rexford S, Ahima, Suzette Y, Osei
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Adipose tissue is the source of soluble mediators (adipokines), secreted mainly by adipocytes. Leptin acts on the brain and peripheral organs to regulate energy homeostasis and the neuroendocrine axis. Adiponectin regulates glucose and lipid metabolism by targeting the liver and skeletal muscle.
Rexford S, Ahima, Suzette Y, Osei
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Nature Reviews Rheumatology, 2016
Adipose tissue secretes highly bioactive factors, the adipokines. Systemic levels of adipokines are often altered in the presence of inflammation. In turn, adipokines affect different tissues and cells systemically as well as locally, contributing to immunomodulatory and bone remodelling mechanisms.
Elena, Neumann +4 more
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Adipose tissue secretes highly bioactive factors, the adipokines. Systemic levels of adipokines are often altered in the presence of inflammation. In turn, adipokines affect different tissues and cells systemically as well as locally, contributing to immunomodulatory and bone remodelling mechanisms.
Elena, Neumann +4 more
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2006
Chronic kidney disease (CKD) is now considered as one of the strongest risk factors for all cause mortality and cardiovascular events. However, the link between CKD and systemic events is unclear. The role of the kidney is primarily considered a target organ during the development of obesity as altered production of adipokines from visceral adipocytes,
Hitomi, Kataoka, Kumar, Sharma
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Chronic kidney disease (CKD) is now considered as one of the strongest risk factors for all cause mortality and cardiovascular events. However, the link between CKD and systemic events is unclear. The role of the kidney is primarily considered a target organ during the development of obesity as altered production of adipokines from visceral adipocytes,
Hitomi, Kataoka, Kumar, Sharma
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Adipokines in Childhood Obesity
2013The worldwide increase in the prevalence of obesity in children and adolescents during the past decades, in addition to mounting evidence indicating that obesity is associated with an increased incidence of comorbidities and the risk of premature death, resulting in a high economical impact, has stimulated obesity-focused research.
Gabriel Ángel, Martos-Moreno +3 more
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Adipokines and Alzheimer's Disease
2011Alzheimer's disease pathology involves β-amyloid and tau. Various potential pharmacological targets are discussed that may be able to alleviate the accumulation of β-amyloid and tau. Possible causes of Alzheimer's disease are discussed involving impaired glucose and lipid metabolism and obesity. Adipokines may be involved in the etiology of Alzheimer's
SORTINO, Maria Angela +2 more
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