Results 111 to 120 of about 75,945 (288)

Metabolic Signatures and Diagnostic Prediction Models for Coronary Artery Disease and Type 2 Diabetes Mellitus: Insights From an Exploratory Study

iNew Medicine, EarlyView.
Metabolomic & lipidomic analysis reveals metabolic overlap between CAD & T2DM, highlighting 7 key metabolites as potential biomarkers. A predictive model based on these achieves high accuracy, potentially advancing precision medicine & metabolic insights.
Zhihua Wang, Meiming Su, Ying Li, Yapei Li, Shuo Chen, Ting Peng, Hans Strijdom, Jiangang Wang, Jianping Weng, Suowen Xu   +9 more
wiley   +1 more source

Adipokines and their possible role in obesity and type 2 diabetes mellitus [PDF]

Саратовский научно-медицинский журнал, 2018
The adipose tissue is the endocrine organ secreting polypeptide factors, such as adipokines, which are involved in the regulation of feeding behavior, the metabolic, endocrine and inflammatory processes and insulin sensitivity.
Kuznetsova L.A., Shpakov А.О.
doaj  

Adipokines in neurovascular diseases

Biomedicine & Pharmacotherapy, 2018
Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic stroke.
Opatrilova, Radka, Caprnda, Martin, Kubatka, Peter, Valentova, Vanda, Uramova, Sona, Nosal, Vladimir, Gaspar, Ludovit, Zachar, Luckas, Mozos, Ioana, Petrovic, Daniel, Dragasek, Jozef, Filipova, Slavomira, Büsselberg, Dietrich, Zulli, Anthony, Rodrigo, Luis, Kruzliak, Peter, Krasnik, Vladimir   +16 more
openaire   +3 more sources

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source

Sepsis-Induced Adipokine Change with regard to Insulin Resistance

International Journal of Inflammation, 2012
Background. Assessment of white adipose tissue has changed in recent years, with WAT now being considered as an active endocrine organ, secreting a large number of bioactive mediators, so-called adipokines.
Andreas Hillenbrand, Manfred Weiss, Uwe Knippschild, Anna Maria Wolf, Markus Huber-Lang   +4 more
doaj   +1 more source

The role of adipokines in skeletal muscle inflammation and insulin sensitivity

Journal of Inflammation, 2018
Background There is currently an unmet clinical need to develop better pharmacological treatments to improve glucose handling in Type II Diabetes patients with obesity.
Thomas Nicholson, Chris Church, David J. Baker, Simon W. Jones   +3 more
doaj   +1 more source

Adipokines in pregnancy

Reproductive success consists of a sequential events chronology, starting with the ovum fertilization, implantation of the embryo, placentation, and cellular processes like proliferation, apoptosis, angiogenesis, endocrinology, or metabolic changes, which taken together finally conduct the birth of healthy offspring.
Dawid, Monika, Pich, Karolina, Mlyczyńska, Ewa, Respekta-Długosz, Natalia, Wachowska, Dominika, Greggio, Aleksandra, Szkraba, Oliwia, Kurowska, Patrycja, Rak, Agnieszka   +8 more
openaire   +3 more sources

Identification of Clinical Factors Associated With the Immunogenicity of Homologous ChAdOx1‐nCoV‐19 Vaccine in Hemodialysis Patients

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hemodialysis (HD) patients are at higher risk of severe COVID‐19 and may exhibit suboptimal vaccine responses. This study evaluates the factors influencing vaccine‐induced immunity in HD patients following the second dose of the Vaxzevria. A total of 276 HD patients and 126 controls were included. Antibody responses were assessed using binding
Chia‐Wei Chang, Ping‐Hsun Wu, Li‐Yun Chang, Yu‐Ying Huang, Teng‐Hui Huang, Su‐Chu Lee, Yi‐wen Chiu, Shang‐Jyh Hwang, Tsun‐Yung Kuo, Mei‐Chuan Kuo   +9 more
wiley   +1 more source

Pediatric non alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets [PDF]

, 2013
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. NAFLD has emerged to be extremely prevalent, and predicted by obesity and male gender.
Giorgio V, Graziano F, Nobili V., Prono F   +3 more
core   +1 more source

C/EBPα is Essential for Gonadal but Not Inguinal White Adipose Tissue Formation in Mice

Obesity, EarlyView.
Human genetics has linked the gene CEBPA to waist to hip ratio and adipose distribution. We generated mice with AdipoQ‐Cre driven deletion of Cebpa and found these mice to have a specific reduction in gonadal white adipose tissue and myriad other metabolic phenotypes.
Krista Y. Hu, Yu‐Lin Ma, Esme A. Dodge, Olivia A. B. Maguire, Caio V. Matias, Ryan P. Barney, Hector S. Himede, Juliana Gomez Pardo, Miriam Cepeda, Scott M. Gordon, Robert C. Bauer   +10 more
wiley   +1 more source