Results 221 to 230 of about 75,945 (288)

The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction: A Novel Framework to Explain Pathogenesis and Guide Treatment. [PDF]

J Am Coll Cardiol
Packer M.
europepmc   +1 more source

Ellagic Acid Alleviates Abnormal Fat Reduction by Activating the RXRβ–PPARγ Pathways in a CT26 Tumour‐Induced Cachexia Mouse Model

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Cancer cachexia is a syndrome characterized by significant weight loss, particularly of adipose tissue, which negatively impacts patient survival. Pharmacological approaches to prevent this abnormal fat reduction remain poorly defined.
Woo Yong Park, Beomsu Kim, Gahee Song, Sang Hee Kim, Jin‐Hyung Kim, Ja Yeon Park, Se Jin Jung, Wenjun Jiao, Jisoo Han, Taekyoung Kong, Kwang Seok Ahn, Hyun Jeong Kwak, Jae‐Young Um   +12 more
wiley   +1 more source

Obesity Reprogrammes Adipose Extracellular Vesicles to Induce Muscle Atrophy via miR‐150‐5p‐Mediated Transcriptional Silencing

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Sarcopenic obesity, where excess body fat coexists with reduced muscle mass and function, is becoming increasingly common in ageing populations and contributes to poor physical and metabolic health. Although adipose tissue–secreted factors are implicated in muscle decline, the specific mechanisms remain unclear.
Joshua M. J. Price, Michael Macleod, Thomas Nicholson, Caitlin M. Ditchfield, Bethy Airstone, Natalie Lachlan‐Jiraskova, Edward T. Davis, Kostas Tsintzas, Simon W. Jones   +8 more
wiley   +1 more source

Adipokines in preeclampsia: disrupted signaling pathways and novel therapeutic strategies. [PDF]

Eur J Med Res
Abdalla RAH, Parveen N, Iqbal N, Mohamed AAA, Shahid SMA, Elhussein GEMO, Saleem M, Khan MS.   +7 more
europepmc   +1 more source

Age‐Stratified Associations of Sarcopenic Obesity With Mortality in Type 2 Diabetes

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Sarcopenic obesity, the coexistence of sarcopenia and obesity, has been linked to adverse health outcomes due to comorbidity. Evidence on the association between sarcopenic obesity and mortality among individuals with Type 2 diabetes remains limited Methods Sarcopenic obesity was defined using Japan Working Group on Sarcopenic ...
Shinta Yamamoto, Yoshitaka Hashimoto, Fuyuko Takahashi, Moe Murai, Nozomi Yoshioka, Yuto Saijyo, Chihiro Munekawa, Hanako Nakajima, Noriyuki Kitagawa, Takafumi Osaka, Ryosuke Sakai, Hiroshi Okada, Naoko Nakanishi, Saori Majima, Emi Ushigome, Masahide Hamaguchi, Michiaki Fukui   +16 more
wiley   +1 more source

Is Obesity a Modifiable Risk Factor in Multiple Sclerosis? Mechanistic Insights into Neuroinflammation and Oxidative Damage. [PDF]

Pathophysiology
Varra FN, Pagonopoulou O, Varras M, Varra VK, Theodosis-Nobelos P.   +4 more
europepmc   +1 more source

Loss of Lean Mass in Rheumatoid Arthritis Is Associated With Loss of Total and Visceral Fat

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Purpose Rheumatoid cachexia has been described as a process of concurrent muscle loss and gain of adipose tissue. We evaluated longitudinal changes in body composition in patients with rheumatoid arthritis (RA) to evaluate the changes in adiposity that accompany loss of lean mass. Methods We combined and assessed three independent longitudinal
Joshua F. Baker, Jon T. Giles, Babette Zemel, Katherine D. Wysham, Jin Long, Mary Leonard, Patricia Katz   +6 more
wiley   +1 more source

Leptin, Interleukin 6, and Vascular Endothelial Growth Factor as Potential Predictors of Primary Hypertension in Children and Adolescents with Obesity. [PDF]

Int J Mol Sci
Sosnicka A, Jaskulak M, Rysz I, Grzybowska M, Deptuła M, Zawrzykraj M, Pikuła M, Ben-Skowronek I, Zorena K.   +8 more
europepmc   +1 more source

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro‐Oxidative and Pro‐Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Adiponectin deficiency remodels the lipid composition of plasma extracellular vesicles (EV), enriching polyunsaturated phospholipids and reducing lysophospholipids. These remodelled EV impact oxidative, inflammatory and metabolic function in recipient cells.
Sungji Cho, Hye Kyoung Sung, Khang Nguyen, Yubin Lei, Sivaporn Wannaiampikul, Brian Lee, Eddie Tam, Yihan Luo, Evgeniy V. Petrotchenko, Christoph H. Borchers, Kacey J. Prentice, Scott A Summers, Dylan Burger, Gary Sweeney   +13 more
wiley   +1 more source

Adipokine Profile Signature in Adolescent Girls with Menstrual Disorders and Hyperandrogenism Differs from That of Regularly Menstruating Girls. [PDF]

J Clin Med
Foryś E, Drosdzol-Cop A, Małecka-Tendera E, Gawlik-Starzyk AM, Skrzyńska K, Olszanecka-Glinianowicz M, Zachurzok A.   +6 more
europepmc   +1 more source