Results 31 to 40 of about 52,972 (211)

Epigenetic Regulation of Adipokines

, 2017
Adipose tissue expansion in obesity leads to changes in the expression of adipokines, adipocyte-specific hormones that can regulate whole body energy metabolism.
Ji-Young Lee, Tho X. Pham
core   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Adipokines and their role in acute pancreatitis [PDF]

Acute pancreatitis (AP) is characterized by an inflammatory response that leads to edema and haemorrhaging of pancreatic tissue. In severe cases, it can even result in the necrosis of pancreatic tissue following activation within the pancreas. Adipokines
Radoman-Vujačić Irena, Patoulias Dimitrios, Rafaqat Saira, Klisić Aleksandra, Khurshid Huma   +4 more
core   +2 more sources

Genetic variation, adipokines, and cardiometabolic disease

, 2020
Adipokines are adipocyte-secreted cell signalling proteins that travel to distant target organs and tissues, where they regulate a variety of biological actions implicated in cardiometabolic health.
Metz, Sophia, Huang, Lam Opal, Kilpeläinen, Tuomas O.   +2 more
core   +1 more source

Increased circulating ANG II and TNF-α represents important risk factors in obese Saudi adults with hypertension irrespective of diabetic status and BMI [PDF]

, 2012
Central adiposity is a significant determinant of obesity-related hypertension risk, which may arise due to the pathogenic inflammatory nature of the abdominal fat depot.
Bindahman, Lotfi S., Mohamed, Amany O., Draz Hossam M., Saleem, Tahia H., Alkharfy Khalid M., Lotfi S Bindahman, Mohamed Amany O., Omar S Al-Attas, Alokail, Majed S., Al-Attas, Omar S., Al-Attas Omar S., Philip G McTernan, Al-Daghri, Nasser M., Tahia H Saleem, Amany O Mohamed, Hossam M Draz, Harte Alison L., Majed S Alokail, Alison L Harte, Saleem Tahia H., Yakout Sobhy, Harte, Alison L., Al-Daghri Nasser M., Alokail Majed S., Nasser M Al-Daghri, McTernan Philip G., Bindahman Lotfi S., Yakout, Sobhy M., Draz, Hossam M., Alkharfy, Khalid M., McTernan, P. G. (Philip G.), Sobhy Yakout, Khalid M Alkharfy   +32 more
core   +2 more sources

Research progress on the role of adipokines in the pathogenesis of sarcopenia in the elderly [PDF]

, 2023
The change of fat distribution, the decrease of physical activity and the influence of diseases during aging will change the circulating level of adipokines.
DANG Caihong, LI Weixin
core   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

Link Between Umbilical Cord Blood Adipokines and Early Childhood Health [PDF]

Introduction: Early-life neurological and inflammatory disorders significantly affect long-term cognitive, social, and emotional development. The ‘Developmental Origins of Health and Disease’ hypothesis states that an adverse intrauterine ...
Holland, OJ, Ava M. Boyle, Hryciw, DH, Deanne H. Hryciw, Boyle, AM, Olivia J. Holland   +5 more
core   +1 more source

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source