Results 11 to 20 of about 1,003 (148)

Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila [PDF]

Nature Communications
Propagation of intercellular calcium waves through tissues has been found to coordinate different multicellular responses. Nevertheless, our understanding of how calcium waves operate remains limited.
Muhammad Ahmad, Shang Wu, Shengyao Luo, Wenjia Shi, Xuan Guo, Yuansheng Cao, Norbert Perrimon, Li He   +7 more
doaj   +2 more sources

A tumor-secreted protein utilizes glucagon release to cause host wasting [PDF]

Cell Discovery
Tumor‒host interaction plays a critical role in malignant tumor-induced organ wasting across multiple species. Despite known regulation of regional wasting of individual peripheral organs by tumors, whether and how tumors utilize critical host catabolic ...
Guangming Ding, Yingge Li, Chen Cheng, Kai Tan, Yifei Deng, Huiwen Pang, Zhongyuan Wang, Peixuan Dang, Xing Wu, Elisabeth Rushworth, Yufeng Yuan, Zhiyong Yang, Wei Song   +12 more
doaj   +2 more sources

A Cold Stress-Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor. [PDF]

Adv Sci (Weinh)
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Zhou J, Chen J, Zhang H, Guo L, Mai K, Abraham E, Prajapati DV, Chang Y, Ning J, Wang X, Li D, Zhang DD, Sun J, Butcher RA, Zhao L.   +14 more
europepmc   +2 more sources

A South African Scenario: Structure and Function of Peptides of the Adipokinetic Hormone Family of the Brown Locust, Locustana pardalina, and the Putative Role of These Peptides in Plague Management. [PDF]

Arch Insect Biochem Physiol
1. The brown locust produces the three adipokinetic hormones Locmi‐AKH‐I, ‐II and ‐III found also in the migratory locust. 2. Flight is characterised by differential changes in haemolymph carbohydrate and lipid levels. 3. Modelling ligand‐receptor binding is proposed as important step to a new strategy to combat the brown locust.
Gäde G, Marco HG.
europepmc   +2 more sources

Homeostatic Counter-Regulation Mediates Spermidine-Induced Triacylglyceride Reduction in Drosophila melanogaster-From Phenotype to Molecular Mechanism. [PDF]

FASEB J
In Drosophila melanogaster females fed a standard diet containing 2.5% yeast extract (low‐yeast diet), spermidine (Spd) administration does not enhance the endogenous Spd pool but increases the excretion of catabolic N1‐acetylspermidine (N1AcSpd) and reduces fat stores. This process requires the catabolic Akh/AkhR pathway.
Lüersen K, Runke C, Blank-Landeshammer B, Weghuber J, Kühnlein RP, Roeder T, Rimbach G.   +6 more
europepmc   +2 more sources

Localization and functional characterization of a novel adipokinetic hormone in the mollusk, Aplysia californica. [PDF]

PLoS ONE, 2014
Increasing evidence suggests that gonadotropin-releasing hormone (GnRH), corazonin, adipokinetic hormone (AKH), and red pigment-concentrating hormone all share common ancestry to form a GnRH superfamily.
Joshua I Johnson, Scott I Kavanaugh, Cindy Nguyen, Pei-San Tsai   +3 more
doaj   +1 more source

Thermosensory TRPV Heterotetramers Drive Seasonal Polyphenism: Molecular Basis of CcIav/CcNan-PKCα-AKH/AKHR Signaling in Pear Psyllid Morph Transition. [PDF]

Adv Sci (Weinh)
At 2 5 °C, thermal activation initiates: i) CcIav/CcNan heterotetramer assembly → Ca2⁺ influx; ii) CcPKCα phosphorylation → AKH signaling potentiation; iii) CcAKH1 binding to membrane‐localized CcAKHR → energy mobilization (lipid catabolism/glycogenolysis) and vitellogenin transport via follicular patency; iv) Oocyte maturation → summer‐form nymph ...
Li J, Zhang Z, Wang Y, Yang Y, Wang J, Ruan X, Zhang S.   +6 more
europepmc   +2 more sources

AKH Signaling in D. melanogaster Alters Larval Development in a Nutrient-Dependent Manner That Influences Adult Metabolism

Frontiers in Physiology, 2021
Metabolism, growth, and development are intrinsically linked, and their coordination is dependent upon inter-organ communication mediated by anabolic, catabolic, and steroid hormones.
Bryon N. Hughson, MaryJane Shimell, Michael B. O’Connor   +2 more
doaj   +1 more source

Structural Diversity of Adipokinetic Hormones in the Coleopteran Suborder Polyphaga (Excluding Cucujiformia). [PDF]

Arch Insect Biochem Physiol
Adipokinetic hormones of Polyphaga beetles (minus Cucujiformia series) were sequenced and confirmed via mass spectrometry. Schgr‐AKH‐II is assumed as ancestral AKH in Coleoptera. Radiation of AKH diversity during the evolution of Scarabaeoidea. ABSTRACT Beetles are the largest animal group, in general.
Gäde G, König S, Marco HG.
europepmc   +2 more sources

Prediction of neuropeptide precursors and differential expression of adipokinetic hormone/corazonin-related peptide, hugin and corazonin in the brain of malaria vector Nyssorhynchus albimanus during a Plasmodium berghei infection

Current Research in Insect Science, 2021
Insect neuropeptides, play a central role in the control of many physiological processes. Based on an analysis of Nyssorhynchus albimanus brain transcriptome a neuropeptide precursor database of the mosquito was described.
Alejandro Alvarado-Delgado, Jesús Martínez-Barnetche, Juan Téllez-Sosa, Mario H. Rodríguez, Everardo Gutiérrez-Millán, Federico A. Zumaya-Estrada, Vianey Saldaña-Navor, María Carmen Rodríguez, Ángel Tello-López, Humberto Lanz-Mendoza   +9 more
doaj   +1 more source