Results 111 to 120 of about 140,016 (274)

Ironing out the details: Untangling dietary iron and genetic background in diabetes [PDF]

, 2018
The search for genetic risk factors in type-II diabetes has been hindered by a failure to consider dietary variables. Dietary nutrients impact metabolic disease risk and severity and are essential to maintaining metabolic health.
Lawson, Heather A, Miranda, Mario A
core   +2 more sources

GLP‐1 Receptor Agonists in Metabolic Dysfunction‐Associated Steatotic Liver Disease: Bridging Hepatic and Cardiovascular Outcomes

Chronic Diseases and Translational Medicine, EarlyView.
Endogenous GLP‐1 and exogenous GLP‐1 RAs activate GLP‐1R‐expressing vagal afferents in the portal vein, projecting to the nucleus tractus solitarius (NTS). This input engages brainstem–hypothalamic circuits that regulate metabolic homeostasis. Hypothalamic efferent vagal output to the liver suppresses lipogenesis, enhances triglyceride export, and ...
Gabriel Amorim Moreira Alves, Masatoki Teranishi, Rajendranandini Majumdar, Fazal Khan, Mohan Dodeja, Ana Claudia Teixeira de Castro Gonçalves Ortega, Marco Acerboni, Arosh S. Perera Molligoda Arachchige, Frank James   +8 more
wiley   +1 more source

Adiponectin: A Predictor for Breast Cancer Survival?

European Journal of Breast Health, 2019
Objective:Breast cancers in women with low serum adiponectin levels have been reported to show phenotypes that are more aggressive. In 2008, we investigated the relationship between serum adiponectin levels and breast cancer in our case-controlled study ...
Hikmet Erhan Güven, Lütfi Doğan, Mehmet Ali Gülçelik, Neşe Ersöz Gülçelik   +3 more
doaj   +1 more source

T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity. [PDF]

, 2017
BACKGROUND: Endothelial dysfunction plays a critical role in the development of type 2 diabetes (T2DM). T-cadherin (T-cad) has gained recognition as a regulator of endothelial cell (EC) function.
Ambrosio, Anastasia, Lau, Wayne Bond, Ma, Xin-Liang, Summer, Ross, Tao, Ling, Wang, Han, Wang, Yajing, Yan, Wenjun   +7 more
core   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Elevated Serum Adiponectin Levels in Primary Sclerosing Cholangitis (PSC) Compared to Inflammatory Bowel Disease (IBD): A Potential Biomarker for PSC-IBD Screening

Livers
Background/Objectives: Systemic levels of the adipokine adiponectin are elevated in chronic liver disease including primary sclerosing cholangitis (PSC).
Tanja Elger, Muriel Huss, Johanna Loibl, Patricia Mester, Andreas Albert, Arne Kandulski, Martina Müller, Hauke Christian Tews, Christa Buechler   +8 more
doaj   +1 more source

Role of arginase 2 in systemic metabolic activity and adipose tissue fatty acid metabolism in diet-induced obese mice [PDF]

, 2019
Visceral adipose tissue (VAT) inflammation and metabolic dysregulation are key components of obesity-induced metabolic disease. Upregulated arginase, a ureahydrolase enzyme with two isoforms (A1-cytosolic and A2-mitochondrial), is implicated in ...
Atawia, Reem T, Benson, Tyler W, Caldwell, Robert W, Caldwell, Ruth B, Cutler, Christopher W, Meghil, Mohamed M, Toque, Haroldo A, Weintraub, Neal L, Yiew, Nicole K.H   +8 more
core   +2 more sources

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Mediating effect of adiponectin between free fatty acid and tumor necrosis factor-α in patients with diabetes

Nutrition & Diabetes
Background/Objectives Increased free fatty acid (FFA) promotes adiponectin secretion in healthy subjects and induces inflammation in diabetes. Given the potential pro-inflammatory role of adiponectin in “adiponectin paradox”, we performed this study in ...
Zhang Xia, Shulong Shi, Xiaoqing Ma, Feng Li, Xinya Li, Herbert Y. Gaisano, Mingyang Zhao, Yuhao Li, Yan He, Jiajia Jiang   +9 more
doaj   +1 more source

Integral Role of PTP1B in Adiponectin-Mediated Inhibition of Oncogenic Actions of Leptin in Breast Carcinogenesis

Neoplasia: An International Journal for Oncology Research, 2013
The molecular effects of obesity are mediated by alterations in the levels of adipocytokines. High leptin level associated with obese state is a major cause of breast cancer progression and metastasis, whereas adiponectin is considered a “guardian angel ...
LaTonia Taliaferro-Smith, Arumugam Nagalingam, Brandi Brandon Knight, Elaine Oberlick, Neeraj K. Saxena, Dipali Sharma   +5 more
doaj   +1 more source