Results 131 to 140 of about 99,913 (245)
Effect of high glucose on expression of adiponectin through ERK1/2 signaling pathway in HK-2 cells
Linchuang shenzangbing zazhi, 2016 Objective Adiponectin is closely related to the development of diabetic kidney disease.Recent evidence suggests that human proximal tubular epithelial cells could express and secrete adiponectin and the expression of adiponectin could be inhibited by ...
WU Sai-qun +3 more
doaj
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims To investigate the sex‐stratified associations of DXA‐derived adiposity, regional fat distribution and muscle power with incident hospitalised cardiovascular disease (CVD) in older Chinese adults. Materials and Methods This prospective cohort included 3168 community‐dwelling older adults (1548 men and 1620 women; median age 72.0 years ...
Ting Zhang +4 more
wiley +1 more source
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Introduction Apical periodontitis (AP) is an inflammatory disease of the periapical tissues driven by host responses to endodontic infection, and systemic metabolic disturbances, such as high‐fat diet (HFD)–induced dysmetabolism, may exacerbate tissue destruction. This study aimed to determine how chronic HFD exposure alters periapical myeloid
Maryam Ghaffari +3 more
wiley +1 more source
Immune Consequences of Metabolic Syndrome and Its Treatment: A Cytokine Perspective
Immunology, EarlyView.Peripheral blood mononuclear cells (PBMCs) from individuals with metabolic syndrome (MetS) who were not using glucose‐and/or lipid lowering medication (GLLM) exhibited a broader cytokine production profile after in vitro antigen‐specific stimulation than PBMCs from individuals with MetS using such medications and from healthy donors.
Isabela Ghetti Macedo Isaac +7 more
wiley +1 more source
Journal of Diabetes Investigation, EarlyView.Among patients with type 2 diabetes undergoing percutaneous coronary intervention, thiazolidinedione use was independently associated with a significantly reduced risk of a composite of myocardial infarction, stroke, and all‐cause death, notably without an increased risk of admission for heart failure. ABSTRACT Background Thiazolidinediones (TZD) are a
Jinkwon Kim +5 more
wiley +1 more source
Effect of Poly (ADP-ribose) Polymerase Inhibitors on Hypoadiponectinemia Caused by Chronic Blockade of Nitric Oxide Synthesis in Rats [PDF]
, 2005 Oxidant stress-induced activation of poly (ADP-ribose) polymerase (PARP) contributes to the pathogenesis of various cardiovascular diseases. Adiponectin is an adipocyte-derived anti-atherogenic protein.
Kase, Hiroyuki +6 more
core
Journal of Internal Medicine, EarlyView.Abstract Lipodystrophy comprises a heterogeneous group of disorders characterized by reduced adipose tissue often associated with severe metabolic complications. Lipodystrophy may be genetic, acquired, or secondary to medical therapies initiated for other conditions.
Robert K. Semple +25 more
wiley +1 more source
Estudo da influência da dieta e do inibidor da fosfodiesterase 5 tadalafil nas concentrações de citocinas inflamatórias, óxido nítrico e produtos finais de glicação avançada no tecido adiposo de ratos [PDF]
, 2014 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2014.Abstract : Introdução: Nas últimas décadas, descobriu-se que o adipócito era capaz de secretar ...
Colombo, Giovani
core
Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger +5 more
wiley +1 more source