Results 21 to 30 of about 70,562 (248)

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Adiponectin and Adiponectin Receptors in Human Pheochromocytoma

Journal of Atherosclerosis and Thrombosis, 2009
Recent studies have demonstrated that serum adiponectin and its receptors in adipose and muscle tissues are suppressed in diabetic or obese individuals. Patients with pheochromocytoma are frequently diabetic.Using real-time PCR, we examined mRNA expressions of adiponectin (Adp) and adiponectin receptor 1 (AdpR1) and AdpR2 in pheochromocytoma tissues ...
Isobe, Kazumasa, FU, Ling, Tatsuno, Ichirou, Takahashi, Hideto, Nissato, Sumiko, Hara, Hisato, Yashiro, Toru, Suzukawa, Kazumi, Takekoshi, Kazuhiro, Shimano, Hitoshi, Kawakami, Yasushi   +10 more
openaire   +3 more sources

Dimerization of adiponectin receptor 1 is inhibited by adiponectin [PDF]

Journal of Cell Science, 2010
AdipoR1 and AdipoR2 are newly discovered members of the huge family of seven-transmembrane receptors, but both receptors are structurally and functionally different from G-protein-coupled receptors. Little is known about the oligomerization of the AdipoRs.
David, Kosel, John T, Heiker, Cathleen, Juhl, Cornelia M, Wottawah, Matthias, Blüher, Karin, Mörl, Annette G, Beck-Sickinger   +6 more
openaire   +2 more sources

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Short-term overfeeding increases circulating adiponectin independent of obesity status. [PDF]

PLoS ONE, 2013
Adiponectin is an adipose tissue derived hormone which strengthens insulin sensitivity. However, there is little data available regarding the influence of a positive energy challenge (PEC) on circulating adiponectin and the role of obesity status on this
Farrell Cahill, Peyvand Amini, Danny Wadden, Sammy Khalili, Edward Randell, Sudesh Vasdev, Wayne Gulliver, Guang Sun   +7 more
doaj   +1 more source

Effects of interventions on adiponectin and adiponectin receptors

Journal of Exercise Rehabilitation, 2014
Adiponectin secreted from adipose tissue binds to two distinct adiponectin receptors (AdipoR1 and AdipoR2) identified and exerts its anti-diabetic effects in insulin-sensitive organs including liver, skeletal muscle and adipose tissue as well as amelioration of vascular dysfunction in the various vasculatures.
Lee, Sewon, Kwak, Hyo-Bum
openaire   +2 more sources

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Plasma omentin levels are inversely associated with atherosclerosis in type 2 diabetes patients with increased plasma adiponectin levels: a cross-sectional study

Cardiovascular Diabetology, 2019
Background Omentin and adiponectin are among the anti-inflammatory and anti-atherogenic adipokines that have potentially beneficial effects on cardiovascular disorders.
Masami Nishimura, Tomoaki Morioka, Mariko Hayashi, Yoshinori Kakutani, Yuko Yamazaki, Masafumi Kurajoh, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Tetsuo Shoji, Masaaki Inaba, Masanori Emoto   +11 more
doaj   +1 more source

Role of the adiponectin binding protein, T-cadherin (Cdh13), in allergic airways responses in mice. [PDF]

PLoS ONE, 2012
Adiponectin is an adipose derived hormone that declines in obesity. We have previously shown that exogenous administration of adiponectin reduces allergic airways responses in mice.
Alison S Williams, David I Kasahara, Norah G Verbout, Alexey V Fedulov, Ming Zhu, Huiqing Si, Allison P Wurmbrand, Christopher Hug, Barbara Ranscht, Stephanie A Shore   +9 more
doaj   +1 more source

Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients

International Journal of Endocrinology, 2015
The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM).
Dagmar Horáková, Kateřina Azeem, Radka Benešová, Dalibor Pastucha, Vladimír Horák, Lenka Dumbrovská, Arnošt Martínek, Dalibor Novotný, Zdeněk Švagera, Milada Hobzová, Dana Galuszková, Vladimír Janout, Sandra Doněvská, Jana Vrbková, Helena Kollárová   +14 more
doaj   +1 more source