Results 91 to 100 of about 347,415 (326)

Cold Plasma Generates a Localized Inflammatory Response and Promotes Muscle Repair

Advanced Therapeutics, EarlyView.
The immediate tissue response to plasma is a pro‐inflammatory response which is characterized by collagen clumping, innate immune cell infiltration, enhanced metabolic processes, and decreased apoptosis. The long‐term tissue response (4‐ and 14‐days) to plasma treatment is characterized by a decreased inflammatory response, decreased adipogenesis, and ...
Carly J. Smith, Amanda R. Watkins, Abigail A. Lucas, Arianna J. Moniodes, Conn Ritchie, Thomas P. Thompson, Thomas P. Schaer, Brendan F. Gilmore, Noreen J. Hickok, Theresa A. Freeman   +9 more
wiley   +1 more source

Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch

Nature Communications, 2018
JMJD1A is essential for thermogenic gene induction in brown adipose tissue. Here the authors show that white adipose tissue beige-ing requires both β-adrenergic-dependent phosphorylation of S265 and demethylation activity of JMJD1A while brown adipose ...
Yohei Abe, Yosuke Fujiwara, Hiroki Takahashi, Yoshihiro Matsumura, Tomonobu Sawada, Shuying Jiang, Ryo Nakaki, Aoi Uchida, Noriko Nagao, Makoto Naito, Shingo Kajimura, Hiroshi Kimura, Timothy F. Osborne, Hiroyuki Aburatani, Tatsuhiko Kodama, Takeshi Inagaki, Juro Sakai   +16 more
doaj   +1 more source

The Circadian Clock in White and Brown Adipose Tissue: Mechanistic, Endocrine, and Clinical Aspects.

Endocrine reviews, 2018
Obesity is a major risk factor for the development of illnesses, such as insulin resistance and hypertension, and has become a serious public health problem. Mammals have developed a circadian clock located in the hypothalamic suprachiasmatic nuclei (SCN)
O. Froy, M. Garaulet
semanticscholar   +1 more source

Case report: brown fat accumulation of Tc-99m macroaggregated albumin in a lung perfusion study in a patient with multiple lung arteriovenous malformations and right-to-left shunting [PDF]

, 2015
An 18-year-old man was preoperatively assessed for a varicocele and found to be hypoxemic. A Tc-99m macroaggregated albumin lung perfusion scan showed right-to-left shunting, evidenced by increased radiotracer uptake in the brain, kidneys, thyroid gland,
Marashdeh, Wael, Wahl, Richard L
core   +2 more sources

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

Captive rearing effects on the methylome of Atlantic salmon after oceanic migration: Sex‐specificity and intergenerational stability

Molecular Ecology Resources, EarlyView., 2023
Abstract Captive rearing in salmon hatcheries can have considerable impacts on both fish phenotype and fitness within a single generation, even in the absence of genetic change. Evidence for hatchery‐induced changes in DNA methylation is becoming abundant, though questions remain on the sex‐specificity of these effects, their persistence until spawning
Clare J. Venney, Raphaël Bouchard, Julien April, Eric Normandeau, Laurie Lecomte, Guillaume Côté, Louis Bernatchez   +6 more
wiley   +1 more source

Latest Advancements on Combating Obesity by Targeting Human Brown/Beige Adipose Tissues

Frontiers in Endocrinology, 2022
Obesity is defined as overaccumulation of white adipose tissue in the body, mainly under the skin (subcutaneous adiposity) or in the abdominal cavity (visceral adiposity).
Ruping Pan, Yong Chen, Yong Chen, Yong Chen   +3 more
doaj   +1 more source

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Advanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou   +15 more
wiley   +1 more source

Multiple regulatory steps are involved in the control of lipoprotein lipase activity in brown adipose tissue.

Journal of Lipid Research, 1996
Lipoprotein lipase (LPL) supplies brown adipose tissue with fatty acids for nonshivering thermogenesis. In brown adipose tissue of the Djungarian hamster we studied i) the molecular mechanisms involved in cold-induced stimulation of LPL activity, ii) the
M Klingenspor, C Ebbinghaus, G Hülshorst, S Stöhr, F Spiegelhalter, K Haas, G Heldmaier   +6 more
doaj  

Adipocytes and Stromal Cells Regulate Brown Adipogenesis Through Secretory Factors During the Postnatal White-to-Brown Conversion of Adipose Tissue in Syrian Hamsters

Frontiers in Cell and Developmental Biology, 2021
Brown adipose tissue (BAT) is a specialized tissue that regulates non-shivering thermogenesis. In Syrian hamsters, interscapular adipose tissue is composed primarily of white adipocytes at birth, which is converted to BAT through the proliferation and ...
Junnosuke Mae, Kazuki Nagaya, Yuko Okamatsu-Ogura, Ayumi Tsubota, Shinya Matsuoka, Junko Nio-Kobayashi, Kazuhiro Kimura   +6 more
doaj   +1 more source