Results 131 to 140 of about 359,090 (346)

[18F]F-AraG imaging reveals association between neuroinflammation and brown- and bone marrow adipose tissue

Communications Biology
Brown and brown-like adipose tissues have attracted significant attention for their role in metabolism and therapeutic potential in diabetes and obesity.
Jelena Levi, Caroline Guglielmetti, Timothy J. Henrich, John C. Yoon, Prafulla C. Gokhale, David A. Reardon, Juliet Packiasamy, Lyna Huynh, Hilda Cabrera, Marisa Ruzevich, Joseph Blecha, Michael J. Peluso, Tony L. Huynh, Sung-Min An, Mark Dornan, Anthony P. Belanger, Quang-Dé Nguyen, Youngho Seo, Hong Song, Myriam M. Chaumeil, Henry F. VanBrocklin, Hee-Don Chae   +21 more
doaj   +1 more source

Administration of the antioxidant n-acetyl-cysteine in pregnant mice has long-term positive effects on metabolic and behavioral endpoints of male and female offspring prenatally exposed to a high-fat diet [PDF]

, 2018
A growing body of evidence suggests the consumption of high-fat diet (HFD) during pregnancy to model maternal obesity and the associated increase in oxidative stress (OS), might act as powerful prenatal stressors, leading to adult stress-related ...
Arese, Marzia, Bellisario, Veronica, Berry, Alessandra, Cirulli, Francesca, Magnifico, Maria C, Panetta, Pamela, Raggi, Carla   +6 more
core   +3 more sources

Brown Adipocyte-Specific PPAR&ggr; (Peroxisome Proliferator-Activated Receptor &ggr;) Deletion Impairs Perivascular Adipose Tissue Development and Enhances Atherosclerosis in Mice

Arteriosclerosis, Thrombosis and Vascular Biology, 2018
Objective— Perivascular adipose tissue (PVAT) contributes to vascular homeostasis by producing paracrine factors. Previously, we reported that selective deletion of PPAR&ggr; (peroxisome proliferator-activated receptor &ggr;) in vascular smooth muscle ...
Wenhao Xiong, Xiangjie Zhao, L. Villacorta, O. Rom, Minerva T. Garcia-Barrio, Yanhong Guo, Yanbo Fan, Tianqing Zhu, Jifeng Zhang, R. Zeng, Y. E. Chen, Zhisheng Jiang, Lin Chang   +12 more
semanticscholar   +1 more source

Brown adipose tissue thermogenesis in humans [PDF]

Diabetologia, 2013
The prevalence of obesity and type 2 diabetes is at epidemic proportions. Classical interventions aimed at targeting obesity, such as reducing energy intake or increasing exercise, are often not effective over the long term. In contrast to white adipocytes, which store energy, brown adipocytes generate heat via mitochondrial uncoupling protein 1 ...
openaire   +3 more sources

Hsa_circ_0026782 Acts as a “Molecular Break” of CREB1‐Mediated Transcription by Promoting Its Phosphorylation at Ser142 That Prevents Keloid Progression

Advanced Science, EarlyView.
Model for the role of hsa_circ_0026782/p‐CREB1 (Ser142) played in keloid. Hsa_circ_0026782 is derived from back‐splicing of ITGA7 exon 4. When hsa_circ_0026782 binds to CREB1, the exposure of the bZIP domain and dimerization of CREB1 are promoted (upper left).
Xin‐Cao Zhong, Chun‐Ye Chen, Zi‐Xuan Feng, Yong Wang, Tao Zhang, Ze‐Ming Zhuang, Zhang‐Rui Wu, Yong‐Zhong Du, Jun Chen, Xiao‐Ying Lin, Wei‐Qiang Tan   +10 more
wiley   +1 more source

Deficiency of Leucine‐Rich Repeat Containing G Protein‐Coupled Receptor 4 in Pancreas Reduces β Cell Mass

Advanced Science, EarlyView.
In islet β cells, LGR4 binds with Rspondin to activate the Wnt‐β‐catenin‐Ccnd1 axis, leading to a subsequent increase in cell proliferation. On the other hand, LGR4 also binds with RANKL, thus suppressing the phosphorylation of p44/p42 MAPK and p65 NF‐κB and subsequent cell apoptosis.
Chao Luo, Yifan Feng, Jiajie Min, Yan Zhao, Ziming Zhu, Lijun Sun, Hao Yin, Yue Yin, Weizhen Zhang   +8 more
wiley   +1 more source

New perspective in fisheries product development: importance of seaweeds as biomass resources [PDF]

, 2013
Brown seaweeds have an important role to preserve coastal ecosystems. Brown seaweeds are also major class for aquacultured seaweeds. They contain valuable nutrients and bioactive components and some of them have not been found in terrestrial plants ...
Miyashita, Kazuo
core  

Brown adipose tissue macrophages control tissue innervation and homeostatic energy expenditure

Nature Immunology, 2017
Tissue macrophages provide immunological defense and contribute to the establishment and maintenance of tissue homeostasis. Here we used constitutive and inducible mutagenesis to delete the nuclear transcription regulator Mecp2 in macrophages.
Yochai Wolf, S. Boura-Halfon, N. Cortese, Zhana Haimon, Hadas Sar Shalom, Y. Kuperman, V. Kalchenko, A. Brandis, Eyal David, Yifat Segal-Hayoun, Louise Chappell-Maor, A. Yaron, Steffen Jung   +12 more
semanticscholar   +1 more source

Brown Adipose Tissue in Cetacean Blubber

PLOS ONE, 2015
Brown adipose tissue (BAT) plays an important role in thermoregulation in species living in cold environments, given heat can be generated from its chemical energy reserves. Here we investigate the existence of BAT in blubber in four species of delphinoid cetacean, the Pacific white-sided and bottlenose dolphins, Lagenorhynchus obliquidens and Tursiops
Satoru Doi, Hirofumi Ohtsuki, Junji Shindo, Masayuki Funaba, Hideki Endo, Kento Amou, Sara Kobayashi, Osamu Hashimoto, Ryo Sato, Ayaka Matsuda, Takehiko Kakizaki, Fumio Terasawa, Takashi Matsuishi, Makoto Sugiyama   +13 more
openaire   +5 more sources

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2+PIRB+ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis

Advanced Science, EarlyView.
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei, Diwen Shou, Siyuan Huang, Yingsi Wang, Quanzhen Liu, Jinfa Liu, Xiaoyu Lv, Yuyi Zeng, Liting Wei, Han Lin, Jiechuan Chen, Yangxiao Chen, Haoyu Zhong, Yanqing Zhou, Wen Ma, Li Wang, Guojun Qian, Jing Guo, Donglin Sun   +18 more
wiley   +1 more source