Results 11 to 20 of about 347,415 (326)

An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

Frontiers in Endocrinology, 2023
Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1.
Xiaomeng Liu, Xiaomeng Liu, Zhi Zhang, Zhi Zhang, Yajie Song, Hengchang Xie, Meng Dong, Meng Dong   +7 more
doaj   +2 more sources

Recent progress in the study of brown adipose tissue [PDF]

Cell & Bioscience, 2011
Brown adipose tissue in mammals plays a critical role in maintaining energy balance by thermogenesis, which means dissipating energy in the form of heat.
Shan, Shifang, Yao, Xuan, Ying, Hao, Zhang, Ying   +3 more
core   +5 more sources

Assessment of brown adipose tissue function [PDF]

Frontiers in Physiology, 2013
In this review we discuss practical considerations for the assessment of brown adipose tissue in rodent models, focusing on mice. The central aim of the review is to provide a critical appraisal of the utility of specialized techniques for assessing brown adipose tissue function in vivo.
Antonio Vidal-Puig, Antonio Vidal-Puig, Samuel Virtue   +2 more
openaire   +5 more sources

PVAT and Its Relation to Brown, Beige, and White Adipose Tissue in Development and Function

Frontiers in Physiology, 2018
Adipose tissue is commonly categorized into three types with distinct functions, phenotypes, and anatomical localizations. White adipose tissue (WAT) is the major energy store; the largest depots of WAT are found in subcutaneous or intravisceral sites ...
Staffan Hildebrand, Jasmin Stümer, Alexander Pfeifer   +2 more
doaj   +2 more sources

Deceptive Brown Adipose Tissue

Journal of the ASEAN Federation of Endocrine Societies
A 23-year-old female presented with headache, palpitation, and hypertensive spells. There was no similar family history. Twenty-four (24) hour urine testing showed elevated normetanephrine level with normal metanephrines [metanephrines 123 mcg/24 hrs (74-297); normetanephrines 5321.16 mcg/24 hrs (73-808)].
Biswajit Payra, Abhranil Dhar, Pankaj Singhania, Akshay Khatri, Pranab Kumar Sahana   +4 more
openaire   +4 more sources

Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation [PDF]

Journal of Lipid Research, 2018
In mammals, white adipose tissue (WAT) stores and releases lipids, whereas brown adipose tissue (BAT) oxidizes lipids to fuel thermogenesis. In obese individuals, WAT undergoes profound changes; it expands, becomes dysfunctional, and develops a low-grade inflammatory state.
Kotzbeck, Petra, Giordano, Antonio, Mondini, Eleonora, Murano, Incoronata, Severi, Ilenia, Venema, Wiebe, Cecchini, Maria Paola, Kershaw, Erin E, Barbatelli, Giorgio, Haemmerle, Guenter, Zechner, Rudolf, Cinti, Saverio   +11 more
openaire   +5 more sources

CD47 Differentially Regulates White and Brown Fat Function [PDF]

Biology Open, 2020
Mechanisms that enhance energy expenditure are attractive therapeutic targets for obesity. Previously we have demonstrated that mice lacking cd47 are leaner, exhibit increased energy expenditure, and are protected against diet-induced obesity.
Li, Dong, Norman-Burgdolf, Heather, Sullivan, Patrick G., Wang, Shuxia   +3 more
core   +4 more sources

BATLAS: Deconvoluting Brown Adipose Tissue [PDF]

Cell Reports, 2018
Recruitment and activation of thermogenic adipocytes have received increasing attention as a strategy to improve systemic metabolic control. The analysis of brown and brite adipocytes is complicated by the complexity of adipose tissue biopsies. Here, we provide an in-depth analysis of pure brown, brite, and white adipocyte transcriptomes.
Perdikari, Aliki, Leparc, German G., Balaz, Miroslav, Pires, Nuno D., Lidell, Martin E., Sun, Wenfei; id_orcid0000-0001-5762-6010, Fernandez-Albert, Francesc, Müller, Sebastian; id_orcid0000-0001-8071-8853, Akchiche, Nassila, Dong, Hua, Balazova, Lucia, Opitz, Lennart, Röder, Eva, Klein, Holger, Stefanicka, Patrik, Varga, Lukas, Nuutila, Pirjo, Virtanen, Kirsi A., Niemi, Tarja, Taittonen, Markku, Rudofsky, Gottfried, Ukropec, Jozef, Enerbäck, Sven, Stupka, Elia, Neubauer, Heike, Wolfrum, Christian   +25 more
openaire   +7 more sources

Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue [PDF]

Cell Reports, 2019
The relation between gut microbiota and the host has been suggested to benefit metabolic homeostasis. Brown adipose tissue (BAT) and beige adipocytes facilitate thermogenesis to maintain host core body temperature during cold exposure. However, the potential impact of gut microbiota on the thermogenic process is confused. Here, we evaluated how BAT and
Min Li, Min Li, Wanzhu Jin, Catherine Hambly, Baoguo Li, Guanlin Wang, Guanlin Wang, Xueying Zhang, Xueying Zhang, Xue liu, Guanghou Shui, Yingga Wu, Yingga Wu, Hanlin Zhang, John R. Speakman, John R. Speakman, John R. Speakman, Li Li, Sin Man Lam, Chaoqun Niu   +19 more
openaire   +6 more sources

Brown Adipose Tissue Growth and Development [PDF]

Scientifica, 2013
Brown adipose tissue is uniquely able to rapidly produce large amounts of heat through activation of uncoupling protein (UCP) 1. Maximally stimulated brown fat can produce 300 watts/kg of heat compared to 1 watt/kg in all other tissues. UCP1 is only present in small amounts in the fetus and in precocious mammals, such as sheep and humans; it is rapidly
Michael E. Symonds
openaire   +3 more sources