Results 81 to 90 of about 82,818 (268)

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source

Comp2Comp: Open-Source Body Composition Assessment on Computed Tomography [PDF]

arXiv, 2023
Computed tomography (CT) is routinely used in clinical practice to evaluate a wide variety of medical conditions. While CT scans provide diagnoses, they also offer the ability to extract quantitative body composition metrics to analyze tissue volume and quality.
arxiv  

CaMKK2 Regulates Macrophage Polarization Induced by Matrix Stiffness: Implications for Shaping the Immune Response in Stiffened Tissues

Advanced Science, EarlyView.
Macrophage phenotypes are influenced by the microenvironment. Matrix stiffness, a key ECM factor, polarizes macrophage toward a pro‐regenerative phenotype in a 3D physiological environment. CaMKK2 selectively regulates stiffness‐induced macrophage polarization, impacting tumor growth and wound healing.
Ya Guan, Min Zhang, Jiyeon Song, Marcos Negrete, Tyler Adcock, Reeva Kandel, Luigi Racioppi, Sharon Gerecht   +7 more
wiley   +1 more source

Characterization of pig skeletal muscle transcriptomes in response to low temperature

Veterinary Medicine and Science, Volume 9, Issue 1, Page 181-190, January 2023., 2023
Low temperature changes the gene expression pattern and biological pathway in pig skeletal muscle. Under low temperature, biological pathways of lipid, amino acid, and carbohydrate metabolism; signal transduction; endocrine, immune, and nervous system; cardiovascular disease; infectious diseases caused by bacteria or viruses; and neurodegenerative ...
DongJie Zhang, Liang Wang, ShouZheng Ma, Hong Ma, Di Liu   +4 more
wiley   +1 more source

Castration promotes the browning of the prostate tumor microenvironment

Cell Communication and Signaling, 2023
Background Adipose tissue has gained attention due to its potential paracrine role. Periprostatic adipose tissue surrounds the prostate and the prostatic urethra, and it is an essential player in prostate cancer progression.
Alejandro Alvarez-Artime, Belen Garcia-Soler, Pedro Gonzalez-Menendez, Sheila Fernandez-Vega, Rafael Cernuda-Cernuda, David Hevia, Juan C. Mayo, Rosa M. Sainz   +7 more
doaj   +1 more source

CeiTEA: Adaptive Hierarchy of Single Cells with Topological Entropy

Advanced Science, EarlyView.
CeiTEA, a novel hierarchical clustering algorithm based on topological entropy, effectively captures complex structures underlying data. By constructing an adaptive multi‐nary partition tree, CeiTEA reveals hierarchical structures and local diversifications, outperforming existing methods in clustering accuracy and consistency and providing the ...
Bowen Tan, Shiying Li, Mengbo Wang, Shuai Cheng Li   +3 more
wiley   +1 more source

Impact of dietary supplementation of unsaturated and saturated fatty acids on bone strength, fatty acids profile of thigh muscle and immune responses in broiler chickens under heat stress

Veterinary Medicine and Science, Volume 9, Issue 1, Page 252-262, January 2023., 2023
Results suggest that there is not beneficial effect of broiler performance due to adding different source of fat in broiler chicken diet under hot condition. Furthermore, the unsaturated fatty acids could improve profile of fatty acids in thigh and enhance immune responses in broiler chickens.
Reza Vakili, Yahya Ebrahimnezhad
wiley   +1 more source

TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway

Experimental and Molecular Medicine, 2023
Fat metabolism: protecting against obesity-related metabolic disorders Studying a protein called TGFBI, which regulates adipose expansion, may help the development of new approaches to protect against obesity and related metabolic disorders such as type ...
Seul Gi Lee, Jongbeom Chae, Seon Min Woo, Seung Un Seo, Ha-Jeong Kim, Sang-Yeob Kim, David D. Schlaepfer, In-San Kim, Hee-Sae Park, Taeg Kyu Kwon, Ju-Ock Nam   +10 more
doaj   +1 more source

The metabolic origins of big size in aquatic mammals [PDF]

arXiv, 2022
The group of large aquatic mammals has representatives being the largest living beings on earth, surpassing the weight and size of dinosaurs. In this paper, we present some empirical evidence and a mathematical model to argue that fat accumulation in marine mammals triggers a series of metabolic events that result in these animals' increased size.
arxiv  

Induction of Cell Death by Combined Treatment with Photosensitizer‐Chitosan Nanoparticles and the Ferroptosis Inducer RSL3 in Breast Cancer Cell Lines

Advanced NanoBiomed Research, EarlyView.
This study demonstrates that combination of phosphosensitizer‐conjugated chitosan nanoparticles and ferroptosis inducer RSL3 increases cell death in mesenchymal breast cancer cells. Data suggests that this is attributed to variations in ferroptosis‐related protein expression, lipid peroxydation and mitochondrial function.
Marek Feith, Saikat Das Sajib, Anne Grethe Myrann, Anders Høgset, Pablo Garrido, Alfredo Martinez, Erik Knutsen, Kirsten Sandvig, Tore Skotland, Gunhild Mari Mælandsmo, Tore‐Geir Iversen   +10 more
wiley   +1 more source