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Deciphering White Adipose Tissue Heterogeneity [PDF]
Biology, 2019 Adipose tissue not only stores energy, but also controls metabolism through secretion of hormones, cytokines, proteins, and microRNAs that affect the function of cells and tissues throughout the body.
Quyen Luong, Jun Huang, Kevin Y. Lee
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Nutrition & Metabolism, 2022 Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining health and homeostasis. Although white adipose tissue and brown adipose tissue are currently considered key endocrine organs, they differ functionally and ...
Sabrina Azevedo Machado +6 more
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An integrated single cell and spatial transcriptomic map of human white adipose tissue
Nature Communications, 2023 Single-cell studies of human white adipose tissue (WAT) provide insights into the specialized cell types in the tissue. Here the authors combine publicly available and newly generated high-resolution and bulk transcriptomic results from multiple human ...
Lucas Massier +27 more
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CD47 differentially regulates white and brown fat function [PDF]
Biology Open, 2020 Mechanisms that enhance energy expenditure are attractive therapeutic targets for obesity. Previously we have demonstrated that mice lacking cd47 are leaner, exhibit increased energy expenditure, and are protected against diet-induced obesity.
Heather Norman-Burgdolf +3 more
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AdipoAtlas: A reference lipidome for human white adipose tissue
Cell Reports Medicine, 2021 Summary: Obesity, characterized by expansion and metabolic dysregulation of white adipose tissue (WAT), has reached pandemic proportions and acts as a primer for a wide range of metabolic disorders.
Mike Lange +6 more
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Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ [PDF]
Proceedings of the Nutrition Society, 2001 The traditional role attributed to white adipose tissue is energy storage, fatty acids being released when fuel is required. The metabolic role of white fat is, however, complex. For example, the tissue is needed for normal glucose homeostasis and a role
P. Trayhurn, J. Beattie
semanticscholar +4 more sources
White adipose tissue mitochondrial metabolism in health and in obesity [PDF]
Obesity Reviews, 2019 White adipose tissue is one of the largest organs of the body. It plays a key role in whole‐body energy status and metabolism; it not only stores excess energy but also secretes various hormones and metabolites to regulate body energy balance.
S. Heinonen +3 more
semanticscholar +3 more sources
Lytic cocktail: An effective method to alleviate severe burn induced hyper-metabolism through regulating white adipose tissue browning [PDF]
Heliyon, 2022 Background: Browning of white adipose tissue is associated with elevated resting metabolic rates and is considered to be one of the indispensable causes of hypermetabolism in burn patients.
Meng Zhang +8 more
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Frontiers in Endocrinology, 2023 Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1.
Xiaomeng Liu +7 more
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Neuroimmune regulation of white adipose tissues [PDF]
The FEBS Journal, 2021 The white adipose tissues (WAT) are located in distinct depots throughout the body. They serve as an energy reserve, providing fatty acids for other tissues via lipolysis when needed, and function as an endocrine organ to regulate systemic metabolism. Their activities are coordinated through intercellular communications among adipocytes and other cell ...
Xinmin Qian +3 more
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