Results 11 to 20 of about 492,704 (351)

Cold-Induced Changes in Gene Expression in Brown Adipose Tissue, White Adipose Tissue and Liver [PDF]

PLoS ONE, 2013
Cold exposure imposes a metabolic challenge to mammals that is met by a coordinated response in different tissues to prevent hypothermia. This study reports a transcriptomic analysis in brown adipose tissue (BAT), white adipose (WAT) and liver of mice in
Andrew M. Shore, A. Karamitri, P. Kemp, J. Speakman, N. Graham, M. Lomax   +5 more
semanticscholar   +10 more sources

Neuroimmune regulation of white adipose tissues [PDF]

The FEBS Journal, 2021
The white adipose tissues (WAT) are located in distinct depots throughout the body. They serve as an energy reserve, providing fatty acids for other tissues via lipolysis when needed, and function as an endocrine organ to regulate systemic metabolism. Their activities are coordinated through intercellular communications among adipocytes and other cell ...
Xinmin Qian, Xia Meng, Shan Zhang, Wenwen Zeng   +3 more
openaire   +2 more sources

Exercise-Mediated Browning of White Adipose Tissue: Its Significance, Mechanism and Effectiveness

International Journal of Molecular Sciences, 2021
As a metabolic organ, adipose tissue plays an important role in regulating metabolism. In adults, most adipose tissue is white adipose tissue (WAT), and excessive expansion of WAT will lead to obesity.
Wang-Jing Mu, Jie Zhu, Min Chen, Liang Guo   +3 more
semanticscholar   +1 more source

Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis

Nature Communications, 2021
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network.
Anna Whitehead, Fynn N. Krause, Amy Moran, Amanda Maccannell, J. Scragg, Ben D. McNally, Edward Boateng, Steven A. Murfitt, S. Virtue, John Wright, J. Garnham, G. Davies, J. Dodgson, J. Schneider, A. Murray, C. Church, A. Vidal-Puig, K. Witte, J. Griffin, L. Roberts   +19 more
semanticscholar   +1 more source

Effects of a Phosphodiesterase inhibitor on the Browning of Adipose Tissue in Mice

Biomedicines, 2022
Cilostazol is a selective inhibitor of phosphodiesterase type 3 (PDE3) that increases intracellular cyclic adenosine monophosphate (cAMP), which plays a critical role in the development of the beige phenotype and the activation of its thermogenic program
Da Hea Seo, Eugene Shin, Yong-ho Lee, Se-Eun Park, Ki Taek Nam, Jae-woo Kim, Bong-Soo Cha   +6 more
doaj   +1 more source

The Emerging Importance of Mitochondria in White Adipocytes: Neither Last nor Least [PDF]

Endocrinology and Metabolism, 2023
The growing recognition of mitochondria’s crucial role in the regulation of white adipose tissue remodeling and energy balance underscores its significance. The marked metabolic diversity of mitochondria provides the molecular and cellular foundation for
Juan Cai, Fenfen Wang, Mengle Shao
doaj   +1 more source

Fatty Acid Metabolite Profiling Reveals Oxylipins as Markers of Brown but Not Brite Adipose Tissue

Frontiers in Endocrinology, 2020
Metabolites of omega-6 and omega-3 polyunsaturated fatty acids are important signaling molecules implicated in the control of adipogenesis and energy balance regulation.
Sebastian Dieckmann, Sebastian Dieckmann, Sebastian Dieckmann, Stefanie Maurer, Stefanie Maurer, Stefanie Maurer, Tobias Fromme, Tobias Fromme, Tobias Fromme, Cécilia Colson, Kirsi A. Virtanen, Ez-Zoubir Amri, Martin Klingenspor, Martin Klingenspor, Martin Klingenspor   +14 more
doaj   +1 more source

AdipoAtlas: Mapping out human white adipose tissue [PDF]

Cell Reports Medicine, 2021
In this issue of Cell Reports Medicine, Lange and colleagues1 significantly improve lipid identification accuracy, detection, and quantification to provide AdipoAtlas, an in-depth lipidomic profile of human white adipose tissue (WAT). Importantly, they define obesity-mediated lipid alterations, which may provide insight into the etiology of associated ...
Abhijit B. Shinde, Elma Zaganjor
openaire   +3 more sources

Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning

International Journal of Molecular Sciences, 2022
The present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. In rodents, when exposed to decreasing temperatures, females activate thermogenesis earlier. Results obtained in humans
Iker Gómez-García, Jenifer Trepiana, Alfredo Fernández-Quintela, Marta Giralt, María P. Portillo   +4 more
openaire   +5 more sources

Differential Tissue Response to Growth Hormone in Mice [PDF]

, 2018
Growth hormone (GH) has been shown to act directly on multiple tissues throughout the body. Historically, it was believed that GH acted directly in the liver and only indirectly in other tissues via insulin‐like growth hormone 1 (IGF‐1).
Banerjee, Ronadip R., Berry, Ryan, Frank, Stuart J., McGinnis, Graham R., Young, Martin E.   +4 more
core   +2 more sources