Results 21 to 30 of about 348,557 (287)
Effects of a Phosphodiesterase inhibitor on the Browning of Adipose Tissue in Mice
Biomedicines, 2022 Cilostazol is a selective inhibitor of phosphodiesterase type 3 (PDE3) that increases intracellular cyclic adenosine monophosphate (cAMP), which plays a critical role in the development of the beige phenotype and the activation of its thermogenic program
Da Hea Seo +6 more
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Fatty Acid Metabolite Profiling Reveals Oxylipins as Markers of Brown but Not Brite Adipose Tissue
Frontiers in Endocrinology, 2020 Metabolites of omega-6 and omega-3 polyunsaturated fatty acids are important signaling molecules implicated in the control of adipogenesis and energy balance regulation.
Sebastian Dieckmann +14 more
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The Emerging Importance of Mitochondria in White Adipocytes: Neither Last nor Least [PDF]
Endocrinology and Metabolism, 2023 The growing recognition of mitochondria’s crucial role in the regulation of white adipose tissue remodeling and energy balance underscores its significance. The marked metabolic diversity of mitochondria provides the molecular and cellular foundation for
Juan Cai, Fenfen Wang, Mengle Shao
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Frontiers in Cardiovascular Medicine, 2020 Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date several types of adipose tissue have been identified, namely white, brown, and beige, that reside in various specific anatomical locations throughout the body. The
Alan Chait, Laura J. den Hartigh
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Cold-Induced Changes in Gene Expression in Brown Adipose Tissue, White Adipose Tissue and Liver
PLoS ONE, 2013 Cold exposure imposes a metabolic challenge to mammals that is met by a coordinated response in different tissues to prevent hypothermia. This study reports a transcriptomic analysis in brown adipose tissue (BAT), white adipose (WAT) and liver of mice in
Andrew M. Shore +5 more
semanticscholar +1 more source
There and Back Again: Leptin Actions in White Adipose Tissue
International Journal of Molecular Sciences, 2020 Leptin is a hormone discovered almost 30 years ago with important implications in metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the amount of fat. The discovery of leptin was a turning point for two principle reasons:
N. Martínez-Sánchez
semanticscholar +1 more source
Regulatory microRNAs in Brown, Brite and White Adipose Tissue
Cells, 2020 MicroRNAs (miRNAs) constitute a class of short noncoding RNAs which regulate gene expression by targeting messenger RNA, inducing translational repression and messenger RNA degradation.
S. Gharanei +6 more
semanticscholar +1 more source
Frontiers in Physiology, 2016 Obesity is currently a serious worldwide public health problem, reaching pandemic levels. For decades, dietary and behavioral approaches have failed to prevent this disease from expanding, and health authorities are challenged by the elevated prevalence ...
Roberto Bravo +8 more
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Beige Adipose Tissue Identification and Marker Specificity—Overview
Frontiers in Endocrinology, 2021 Adipose tissue (AT) is classified based on its location, physiological and functional characteristics. Although there is a clear demarcation of anatomical and molecular features specific to white (WAT) and brown adipose tissue (BAT), the factors that ...
Anna-Claire Pilkington +4 more
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CD47 differentially regulates white and brown fat function
Biology Open, 2020 Mechanisms that enhance energy expenditure are attractive therapeutic targets for obesity. Previously we have demonstrated that mice lacking cd47 are leaner, exhibit increased energy expenditure, and are protected against diet-induced obesity.
Heather Norman-Burgdolf +3 more
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