Results 31 to 40 of about 492,704 (351)

Hypoxia and adipose tissue function and dysfunction in obesity [PDF]

, 2013
The rise in the incidence of obesity has led to a major interest in the biology of white adipose tissue. The tissue is a major endocrine and signalling organ, with adipocytes, the characteristic cell type, secreting a multiplicity of protein factors ...
Di Girolamo M, Hales CN, Himms-Hagen J, Kyrou I, Matsumoto S, Mise H, Ostlund RE, Paul Trayhurn, Pérez de Heredia F, Trayhurn P, Wang GL, World Health Organisation, Yokota T   +12 more
core   +1 more source

Resveratrol and Pterostilbene, Two Analogue Phenolic Compounds, Affect Aquaglyceroporin Expression in a Different Manner in Adipose Tissue [PDF]

, 2018
Aquaglyceroporins (AQPs) are transmembrane channels that mediate glycerol release and glycerol uptake. They are involved in fat metabolism, with implications in obesity. The aim was to determine whether the administration of resveratrol and pterostilbene
Fernández Quintela, Alfredo, González, Marcela, Gómez Zorita, Saioa, Portillo Baquedano, María Puy, Trepiana Arin, Jenifer   +4 more
core   +2 more sources

Regulatory microRNAs in Brown, Brite and White Adipose Tissue

Cells, 2020
MicroRNAs (miRNAs) constitute a class of short noncoding RNAs which regulate gene expression by targeting messenger RNA, inducing translational repression and messenger RNA degradation.
S. Gharanei, K. Shabir, James E. Brown, M. Weickert, T. Barber, I. Kyrou, H. Randeva   +6 more
semanticscholar   +1 more source

miR-34a-/- mice are susceptible to diet-induced obesity [PDF]

, 2016
Objective: MicroRNA (miR)−34a regulates inflammatory pathways, and increased transcripts have been observed in serum and subcutaneous adipose of subjects who have obesity and type 2 diabetes.
Baker, Andrew H., Caslake, Muriel, Collier, Andrew, Donnelly, Iona, Holmes, William, Kurowska-Stolarska, Mariola, Lavery, Christopher A., Miller, Ashley M.   +7 more
core   +1 more source

Calcium sensing receptor as a novel mediator of adipose tissue dysfunction: mechanisms and potential clinical implications

Frontiers in Physiology, 2016
Obesity is currently a serious worldwide public health problem, reaching pandemic levels. For decades, dietary and behavioral approaches have failed to prevent this disease from expanding, and health authorities are challenged by the elevated prevalence ...
Roberto Bravo, Roberto Bravo, Pamela Mattar, Pamela Mattar, Ximena Diaz, Sergio Lavandero, Sergio Lavandero, Sergio Lavandero, Mariana Cifuentes   +8 more
doaj   +1 more source

An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin

Frontiers in Endocrinology, 2023
Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy expenditure, has been extensively studied as a potential avenue to combat obesity.
K. Ziqubu, P. Dludla, S. Mthembu, B. Nkambule, S. Mabhida, B. Jack, T. M. Nyambuya, S. Mazibuko-Mbeje   +7 more
semanticscholar   +1 more source

The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms [PDF]

, 2015
Objectives: The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.
Clark, S., Contarino, A., Cota, D., Diz-Chaves, Y., Fanelli, F., Grammatopoulos, Dimitris, Lehnert, Hendrik, Lu, B., Markovic, Danijela, Penicaud, L., Tabarin, A.   +10 more
core   +3 more sources

Beige Adipose Tissue Identification and Marker Specificity—Overview

Frontiers in Endocrinology, 2021
Adipose tissue (AT) is classified based on its location, physiological and functional characteristics. Although there is a clear demarcation of anatomical and molecular features specific to white (WAT) and brown adipose tissue (BAT), the factors that ...
Anna-Claire Pilkington, Henry A. Paz, Henry A. Paz, Umesh D. Wankhade, Umesh D. Wankhade   +4 more
doaj   +1 more source

FAM13A and POM121C are candidate genes for fasting insulin: functional follow-up analysis of a genome-wide association study [PDF]

, 2018
Aims/hypothesis: By genome-wide association meta-analysis, 17 genetic loci associated with fasting serum insulin (FSI), a marker of systemic insulin resistance, have been identified. To define potential culprit genes in these loci, in a cross-sectional
Arner, Peter, Dahlman, Ingrid, Kulyte, Agne, Lundbäck, Veroniqa, Marcus, Claude, Ryden, Mikael, Strawbridge, Rona J.   +6 more
core   +1 more source

De novo reconstruction of human adipose transcriptome reveals conserved lncRNAs as regulators of brown adipogenesis

Nature Communications, 2018
Long non-coding RNAs are known to regulate mouse white adipose tissue development and brown adipose tissue program expression. Here, the authors construct a roadmap for human long non-coding RNAs expressed in fetal brown adipose tissue, adult omental and
Chunming Ding, Yen Ching Lim, Sook Yoong Chia, Arcinas Camille Esther Walet, Shaohai Xu, Kinyui Alice Lo, Yanling Zhao, Dewen Zhu, Zhihui Shan, Qingfeng Chen, Melvin Khee-Shing Leow, Dan Xu, Lei Sun   +12 more
doaj   +1 more source