Results 61 to 70 of about 493,971 (354)

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem, Mohammed A Alsahli, Ahmad Almatroudi, Faris Alrumaihi, Fahd Khaleefah Alkhaleefah, Arshad Husain Rahmani, Amjad Ali Khan   +6 more
wiley   +1 more source

Spatial Metabolomics Reveals the Effects of Dietary Capsaicin Intervention on Interscapular Adipose Tissue Metabolome in Mice

Foods
Capsaicin is a polyphenol with a well-known anti-obesity potential, which could activate brown adipose tissue and promote the browning of white adipose tissue.
Haoqing Yang, Peiying Zheng, Jiamiao Hu, Zhongjing Lin, Natthida Sriboonvorakul, Shaoling Lin   +5 more
doaj   +1 more source

Gene Expression Analysis of Murine Brown and Subcutaneous Adipose Tissue: Significance with Human

Ожирение и метаболизм, 2015
Gene Expression Analysis of Murine Brown and Subcutaneous Adipose Tissue: Significance with ...
Teona Albertovna Shvangiradze
doaj   +1 more source

Unraveling White Adipose Tissue Heterogeneity and Obesity by Adipose Stem/Stromal Cell Biology and 3D Culture Models

Cells, 2023
The immune and endocrine dysfunctions of white adipose tissue are a hallmark of metabolic disorders such as obesity and type 2 diabetes. In humans, white adipose tissue comprises distinct depots broadly distributed under the skin (hypodermis) and as ...
Leandra S. Baptista, Karina R. Silva, Lara Jobeili, Lucile Guillot, Dominique Sigaudo-Roussel   +4 more
doaj   +1 more source

Association of environmental exposure to perchlorate, nitrate, and thiocyanate with overweight/obesity and central obesity among children and adolescents in the United States of America using data from the National Health and Nutrition Examination Survey (NHANES) 2005–2016

New Directions for Child and Adolescent Development, Volume 2022, Issue 185-186, Page 107-122, November 2022., 2022
Abstract The association of overweight/obesity, and central obesity with thiocyanate (SCN), perchlorate (CIO), and nitrate (NO) in childhood and adolescence is unclear. Therefore, this study aimed to explore this association in 4447 participants comprising children and adolescents (aged 6–19 years) using data from the United States National Health and ...
Qi Jiang, Qin Li
wiley   +1 more source

UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity [PDF]

, 2010
Background The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis. Methodology/Principal Findings Here we report that cyclooxygenase (COX) activity and prostaglandin E2 (PGE2) are crucially ...
A Cederberg, A Cederberg, AE Stenbit, Aimin Xu, AK Bauer, AM Cypess, B Cannon, B Cannon, B Razani, Barbara Cannon, BT Hyman, C Guerra, C Guerra, C Guerra, C Guerra, CJ Narvaez, D Grujic, DE Cummings, DE Cummings, Even Fjære, F Picard, F Ushikubi, G Garruti, G Leonardsson, G Vassaux, H Oberkofler, H Oberkofler, H Oberkofler, H Oberkofler, Haldis Haukaas Lillefosse, HD Gaskins, HM Feldmann, HM Feldmann, Ingeborg Bronstad, J Himms-Hagen, J Kopecky, J Kopecky, J Kopecky, J Kopecky, J Kopecky, J Mercader, JA Timmons, Jacob B. Hansen, Jan Nedergaard, JB Hansen, JB Hansen, JB Hansen, JB Hansen, JB Hansen, JB Hansen, JB Hansen, JG Granneman, JG Granneman, JN Fain, Josep Mercader, Jun Wang, K Muller-Decker, K Ström, K Tsukiyama-Kohara, KA Virtanen, Karsten Kristiansen, L Madsen, L Madsen, L Madsen, L Madsen, L Madsen, Lise Madsen, Lone M. Pedersen, M Abramovitz, M Jimenez, M Jimenez, M Saito, M. Luisa Bonet, MA Nolan, MC Zingaretti, ME Lean, N Dali-Youcef, N Petrovic, NJ Rothwell, P Seale, P Seale, Pedro Araujo, Peter Voshol, Philip Hallenborg, PM Watson, PM Watson, PM Watson, PO Hetu, Qin Hao, RA Koza, Rasmus K. Petersen, Rita De Matteis, RK Petersen, RK Semple, S Cinti, S Cinti, S Collins, S Enerbäck, Saverio Cinti, SG Morham, Stein Ove Døskeland, SY Toh, T Kunikata, Tao Ma, WD van Marken Lichtenbelt, Y Sakuma, YH Tseng, Z Zhou   +107 more
core   +13 more sources

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

Science Translational Medicine, 2019
Tryptophan-derived metabolites from the gut microbiota control miR-181 expression in mouse white adipocytes to regulate metabolism and inflammation.
A. Virtue, S. McCright, Jasmine M Wright, M. T. Jimenez, Walter K. Mowel, Jonathan J. Kotzin, Leonel Joannas, Megha Basavappa, S. Spencer, M. Clark, S. Eisennagel, Adam Williams, M. Levy, M. Levy, Sasikanth Manne, S. Henrickson, S. Henrickson, E. Wherry, Christoph A. Thaiss, Christoph A. Thaiss, E. Elinav, Jorge Henao-Mejia, Jorge Henao-Mejia   +22 more
semanticscholar   +1 more source

Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning [PDF]

, 2019
Type-2 Familial Partial Lipodystrophy is caused by LMNA mutations. Patients gradually lose subcutaneous fat from the limbs, while they accumulate adipose tissue in the face and neck.
A Armani, A Giordano, A Infante, A Koppen, Alessandra Gambineri, AM Cypess, AM Cypess, Assuero Giorgetti, B Gustafson, C Capanni, C Capanni, C Capanni, C Evangelisti, C Le Dour, C Vigouroux, C Zhang, Camilla Pellegrini, CH Choi, Cristina Capanni, CS Patlak, CY Liao, D Araujo-Vilar, D Camozzi, D Dorner, D Li, David Araujo-Vilar, Davide Andrenacci, DG Batrakou, DJ Klionsky, E Mattioli, E Mattioli, Elisa Schena, Elisabetta Mattioli, FJ Ramos, G Bidault, G Lattanzi, G Ruiz de Eguino, Giovanna Lattanzi, HM Ni, J Orava, JC Choi, JC Choi, K Cao, K Frondorf, K Liu, KA Virtanen, Laura Zanotti, M Caron, M Friesen, Manuela Loi, Maria Angela Guzzardi, Marta Columbaro, MC Zingaretti, N Lehman, N Mizushima, N Patni, P Bernasconi, P Cohen, Paolo Morselli, Patricia Iozzo, R Singh, RJ Brown, RL Boguslavsky, S Cinti, S Dominici, S Goldman, S Rodriguez-Acebes, Sabino Prencipe, Saverio Cinti, SJ Goldman, Stefano Squarzoni, V Bereziat, V Cenni, V Cenni, V Garcia-Alonso, V Ouellet, V Ouellet, Y Liu, Z Dou   +78 more
core   +2 more sources

Lipolysis and lipases in white adipose tissue – An update [PDF]

Archives of Endocrinology and Metabolism, 2015
Lipolysis is defined as the sequential hydrolysis of triacylglycerol (TAG) stored in cell lipid droplets. For many years, it was believed that hormone-sensitive lipase (HSL) and monoacylglycerol lipase (MGL) were the main enzymes catalyzing lipolysis in the white adipose tissue.
Bolsoni-Lopes, Andressa, Alonso-Vale, Maria Isabel C.   +1 more
openaire   +6 more sources

Mesenchymal stem cells: A novel treatment option for primary sclerosing cholangitis

Cell Biology International, Volume 47, Issue 2, Page 467-479, February 2023., 2023
Abstract Primary sclerosing cholangitis (PSC) is a progressive liver disease for which there is no effective therapy. Hepatocytes and cholangiocytes from a PSC patient were cocultured with mesenchymal stem cells (MSCs) to assess in vitro change. A single patient with progressive PSC was treated with 150 million MSCs via direct injection into the common
Amy L. Lightner, Neda Dadgar, Anil Vaidya, Robert Simon, Clifton Fulmer, Hassan Siddiki, K. V. Narayanan Menon, Peter Liu, R. Matthew Walsh   +8 more
wiley   +1 more source