Results 61 to 70 of about 251,315 (215)
Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice [PDF]
, 2017 The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population.
Adams +34 more
core +1 more source
Immune Cells Gate White Adipose Tissue Expansion [PDF]
Endocrinology, 2019 The immune system plays a critical role in white adipose tissue (WAT) energy homeostasis and, by extension, whole-body metabolism. Substantial evidence from mouse and human studies firmly establishes that insulin sensitivity deteriorates as a result of subclinical inflammation in the adipose tissue of individuals with diabetes.
Aaron R Cox +3 more
openaire +2 more sources
Lipids in Health and Disease, 2020 Obesity exhibits a correlation with metabolic inflammation and endoplasmic reticulum stress, promoting the progression of metabolic disease such as diabetes, hyperlipidemia, hyperuricemia and so on.
Yunjia Li, Ke Yun, Runqing Mu
doaj +1 more source
Dielectric properties measurements of brown and white adipose tissue in rats from 0.5 to 10 GHz [PDF]
, 2016 Brown adipose tissue (BAT) plays an important role in whole body metabolism and with appropriate stimulus could potentially mediate weight gain and insulin sensitivity.
Colebeck, E. +6 more
core +2 more sources
Glucocorticoid Receptor and Adipocyte Biology. [PDF]
, 2018 Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels.
Harris, Charles A +2 more
core +2 more sources
Dexamethasone Inhibits White Adipose Tissue Browning
International Journal of Molecular SciencesWhite adipose tissue (WAT) regulates energy balance through energy storage, adipokines secretion and the thermogenesis process. Beige adipocytes are responsible for WAT thermogenesis. They are generated by adipogenesis or transdifferentiation during cold or β3-adrenergic agonist stimulus through a process called browning.
Alejandra Paula Giordano +8 more
openaire +4 more sources
The Impact of the Adipose Organ Plasticity on Inflammation and Cancer Progression
Cells, 2019 Obesity is characterized by chronic and low-grade systemic inflammation, an increase of adipose tissue, hypertrophy, and hyperplasia of adipocytes.
Luís Henrique Corrêa +2 more
doaj +1 more source
Noggin depletion in adipocytes promotes obesity in mice. [PDF]
, 2019 ObjectiveObesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic proteins (BMPs) influence adipogenesis, the effect of BMP antagonists such as Noggin ...
Blázquez-Medela, Ana M +14 more
core +1 more source
Perivascular adipose tissue inflammation in vascular disease [PDF]
, 2017 Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
core +1 more source
Enzymatic intracrine regulation of white adipose tissue [PDF]
Hormone Molecular Biology and Clinical Investigation, 2014 Abstract Abdominal fat formation has become a permanent risk factor for metabolic syndrome and various cancers in one-third of the world’s population of obese and even lean patients. Formation of abdominal fat involves additional mechanisms beyond an imbalance in energy intake and expenditure, which explains systemic obesity.
David, DiSilvestro +5 more
openaire +2 more sources