The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs
Science Translational Medicine, 2019 Tryptophan-derived metabolites from the gut microbiota control miR-181 expression in mouse white adipocytes to regulate metabolism and inflammation.
A. Virtue +22 more
semanticscholar +1 more source
Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathway [PDF]
, 2007 *Background* It has been previously reported that most mammalian genes display a circadian oscillation in their baseline expression. Consequently, the phase and amplitude of each component of a signal transduction cascade has downstream ...
A Savitzky +17 more
core +3 more sources
Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. [PDF]
, 2017 Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt to energy demands under stress, whereas superfluous lipolysis causes metabolic disorders, including dyslipidemia and hepatic steatosis. Glucocorticoid-induced lipolysis requires the
Broughton, Augusta E +6 more
core +1 more source
The role of fibroblast growth factors in cell and cancer metabolism
FEBS Letters, EarlyView.Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source
TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway
Experimental and Molecular Medicine, 2023 Fat metabolism: protecting against obesity-related metabolic disorders Studying a protein called TGFBI, which regulates adipose expansion, may help the development of new approaches to protect against obesity and related metabolic disorders such as type ...
Seul Gi Lee +10 more
doaj +1 more source
Chronic l-menthol-induced browning of white adipose tissue hypothesis: A putative therapeutic regime for combating obesity and improving metabolic health [PDF]
, 2016 Obesity constitutes a serious global health concern reaching pandemic prevalence rates. The existence of functional brown adipose tissue (BAT) in adult humans has provoked intense research interest in the role of this metabolically active tissue in whole-
Andrade, Cl��udia Marlise Balbinotti +11 more
core +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Sex matters: The effects of biological sex on adipose tissue biology and energy metabolism
Redox Biology, 2017 Adipose tissue is a complex and multi-faceted organ. It responds dynamically to internal and external stimuli, depending on the developmental stage and activity of the organism.
Teresa G. Valencak +2 more
doaj +1 more source
Cold-induced lipid dynamics and transcriptional programs in white adipose tissue
BMC Biology, 2019 In mammals, cold exposure induces browning of white adipose tissue (WAT) and alters WAT gene expression and lipid metabolism to boost adaptive thermogenesis and maintain body temperature.
Ziye Xu +5 more
semanticscholar +1 more source
Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice [PDF]
, 2017 The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population.
Adams +34 more
core +1 more source