Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk [PDF]
, 2019 BACKGROUND: Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα ...
Dong, Jiangling +7 more
core +2 more sources
The Circadian Clock in White and Brown Adipose Tissue: Mechanistic, Endocrine, and Clinical Aspects.
Endocrine reviews, 2018 Obesity is a major risk factor for the development of illnesses, such as insulin resistance and hypertension, and has become a serious public health problem. Mammals have developed a circadian clock located in the hypothalamic suprachiasmatic nuclei (SCN)
O. Froy, M. Garaulet
semanticscholar +1 more source
FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue
Molecular Metabolism, 2017 Objective: Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates metabolic homeostasis. Previous work has suggested that impairment of FGF21 signaling in adipose tissue may occur through downregulation of the obligate FGF21 co ...
Kathleen R. Markan +5 more
doaj
Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation [PDF]
Diabetes & Metabolism Journal, 2019 Adipose tissue inflammation is considered a major contributing factor in the development of obesity-associated insulin resistance and cardiovascular diseases. However, the cause of adipose tissue inflammation is presently unclear.
Chang-Yun Woo +4 more
doaj +1 more source
Adipose tissue: colors, depots and functions
Ожирение и метаболизм, 2021 Obesity is a chronic disease characterized by excessive accumulation of adipose tissue. The prevalence of obesity and associated diseases has prompted researchers to expand the study of the biology of adipose tissue.
T. I. Romantsova
doaj +1 more source
Effect of Exercise on Fatty Acid Metabolism and Adipokine Secretion in Adipose Tissue [PDF]
, 2019 Increased physical activity is an optimal way to maintain a good health. During exercise, triacylglycerols, an energy reservoir in adipose tissue, are hydrolyzed to free fatty acids (FAs) which are then released to the circulation, providing a fuel for
Barone R +4 more
core +1 more source
Adipose-Derived Stem Cells: Isolation, Characterization, and Differentiation Potential
Cell Transplantation, 2013 In mammals, the two main types of adipose tissues, white and brown adipose tissues, exert different physiological functions. White adipose tissue (WAT) is for storing energy, while brown adipose tissue (BAT) is for energy consumption.
Shyh-Jer Huang +9 more
doaj +1 more source
The Impact of the Adipose Organ Plasticity on Inflammation and Cancer Progression
Cells, 2019 Obesity is characterized by chronic and low-grade systemic inflammation, an increase of adipose tissue, hypertrophy, and hyperplasia of adipocytes.
Luís Henrique Corrêa +2 more
doaj +1 more source
Metabolic control by AMPK in white adipose tissue
Trends in Endocrinology & Metabolism, 2023 White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new ...
Olga Göransson +2 more
openaire +3 more sources
TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue
Nature Communications, 2018 Remodelling of energy storing white fat into energy expending beige fat could be a promising strategy to reduce adiposity. Here, we show that the bile acid-responsive membrane receptor TGR5 mediates beiging of the subcutaneous white adipose tissue (scWAT)
L. Velázquez-Villegas +6 more
semanticscholar +1 more source