Results 81 to 90 of about 493,971 (354)

Fibroblast Growth Factor 21 and Browning of White Adipose Tissue

Frontiers in Physiology, 2019
Interest has been focused on differentiating anatomical, molecular, and physiological characteristics of the types of mammalian adipose tissues. White adipose tissue (WAT) and brown adipose tissue (BAT) are the two main forms of adipose tissue in humans.
R. Matteis, D. Cuevas-Ramos, R. Mehta, C. Aguilar-Salinas   +3 more
semanticscholar   +1 more source

Pre- and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology [PDF]

, 2016
To view supplementary material for this article, please visit http://dx.doi.org/10.1017/S1751731116000872Both white and brown adipose tissues are recognized to be differently involved in energy metabolism and are also able to secrete a variety of ...
Bonnet, Muriel, Gondret, Florence, Louveau, Isabelle, Perruchot, Marie-Hélène   +3 more
core   +3 more sources

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

Molecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa, Zdenka Herudkova, Jan Hyl, Jakub Vlazny, Filip Sokol, Kvetoslava Matulova, Adam Folta, Jakub Hynst, Lucy Vojtova, Leos Kren, Martin Repko, Zdenek Racil, Jiri Mayer, Martin Culen   +13 more
wiley   +1 more source

Sex differences in body composition in youth with type 1 diabetes and its predictive value in cardiovascular disease risk assessment

Diabetes/Metabolism Research and Reviews, Volume 39, Issue 1, January 2023., 2023
Abstract Background Women with type 1 diabetes (T1D) are more susceptible than men to cardiovascular disease (CVD). Signs of increased risk may already appear among adolescent girls. Objectives We explored the contribution of body composition to the development of CVD risk factors among youth with T1D.
Avivit Brener, Sandy Hamama, Hagar Interator, Asaf Ben Simon, Irina Laurian, Anna Dorfman, Efrat Chorna, Michal Yackobovitch‐Gavan, Asaf Oren, Ori Eyal, Yael Lebenthal   +10 more
wiley   +1 more source

Computational modeling of the physical features that influence breast cancer invasion into adipose tissue [PDF]

APL Bioengineering 8 (2024) 036104
Breast cancer invasion into adipose tissue strongly influences disease progression and metastasis. The degree of cancer cell invasion into adipose tissue depends on numerous biochemical and physical properties of cancer cells, adipocytes, and other key components of adipose tissue.
arxiv   +1 more source

Systems biology of human adipocytes: from genes and molecular networks to heterogeneity and metabolic phenotypes [PDF]

, 2018
Obesity and its co-morbidities are among the leading health problems facing the developed world. Multiple genetic and environmental factors are known to have a significant impact on obesity development, however, heterogeneity of adipose tissue also ...
Ramirez, Alfred Klaus
core  

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

FEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang, Jiang Tan, Xueting He, Yuqin Chen, Guoping Qiu, Mei Yang   +5 more
wiley   +1 more source

Brown adipose tissue and regulation of human body weight

Diabetes/Metabolism Research and Reviews, Volume 39, Issue 1, January 2023., 2023
Abstract Background Approximately 30% of the global population is affected by obesity. Traditional non‐surgical measures for weight loss have limited efficacy and tolerability. Therefore, there is a need for novel, effective therapies. Brown adipose tissue (BAT) has been implicated in physiological energy expenditure, indicating that it could be ...
Elissa Harb, Omar Kheder, Gishani Poopalasingam, Razi Rashid, Akash Srinivasan, Chioma Izzi‐Engbeaya   +5 more
wiley   +1 more source

TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway

Experimental and Molecular Medicine, 2023
Fat metabolism: protecting against obesity-related metabolic disorders Studying a protein called TGFBI, which regulates adipose expansion, may help the development of new approaches to protect against obesity and related metabolic disorders such as type ...
Seul Gi Lee, Jongbeom Chae, Seon Min Woo, Seung Un Seo, Ha-Jeong Kim, Sang-Yeob Kim, David D. Schlaepfer, In-San Kim, Hee-Sae Park, Taeg Kyu Kwon, Ju-Ock Nam   +10 more
doaj   +1 more source

The Role of Tumor and Tumor Microenvironment on Breast Cancer-Associated Adipocyte Plasticity [PDF]

, 2019
Cancer-associated cachexia is a condition defined by a sustained net-negative energy imbalance. Although the different types of adipose tissue – white, beige, and brown – have been implicated in contributing to cancer-associated cachexia, the mechanisms ...
Pearce, Janina V
core   +1 more source