Results 101 to 110 of about 4,418,865 (434)
FAM13A and POM121C are candidate genes for fasting insulin: functional follow-up analysis of a genome-wide association study [PDF]
, 2018 Aims/hypothesis: By genome-wide association meta-analysis, 17 genetic loci associated with fasting serum insulin (FSI), a marker of systemic insulin resistance, have been identified. To define potential culprit genes in these loci, in a cross-sectional
Arner, Peter +6 more
core +1 more source
BMC Bioinformatics, 2019 Background The main research topic in this paper is how to compare multiple biological experiments using transcriptome data, where each experiment is measured and designed to compare control and treated samples.
Benjamin Hur +5 more
doaj +1 more source
Sparse multi-view matrix factorisation: a multivariate approach to multiple tissue comparisons [PDF]
, 2015 Gene expression levels in a population vary extensively across tissues. Such heterogeneity is caused by genetic variability and environmental factors, and is expected to be linked to disease development. The abundance of experimental data now enables the identification of features of gene expression profiles that are shared across tissues, and those ...
arxiv +1 more source
Plum pudding random medium model of biological tissue toward remote microscopy from spectroscopic light scattering [PDF]
Biomed. Opt. Express 8, 2879-2895 (2017), 2017 Biological tissue has a complex structure and exhibits rich spectroscopic behavior. There is \emph{no} tissue model up to now able to account for the observed spectroscopy of tissue light scattering and its anisotropy. Here we present, \emph{for the first time}, a plum pudding random medium (PPRM) model for biological tissue which succinctly describes ...
arxiv +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics. [PDF]
, 2015 ObjectiveSalsalate treatment has well-known effects on improving glycemia, and the objective of this study was to examine whether the mechanism of this effect was related to changes in adipose tissue.MethodsA randomized double-blind and placebo ...
Alderete, Tanya L +9 more
core +3 more sources
The Impact of the Adipose Organ Plasticity on Inflammation and Cancer Progression
Cells, 2019 Obesity is characterized by chronic and low-grade systemic inflammation, an increase of adipose tissue, hypertrophy, and hyperplasia of adipocytes.
Luís Henrique Corrêa +2 more
doaj +1 more source
Frontiers in Sports and Active Living, 2020 The menopausal transition is accompanied by changes in adipose tissue storage, leading to an android body composition associated with increased risk of type 2 diabetes and cardiovascular disease in post-menopausal women.
Camilla M. Mandrup +20 more
doaj +1 more source
FEBS Open Bio, EarlyView.T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang +5 more
wiley +1 more source
Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity. [PDF]
, 2019 Decreased adipose tissue oxygen tension and increased HIF-1α expression can trigger adipose tissue inflammation and dysfunction in obesity. Our current understanding of obesity-associated decreased adipose tissue oxygen tension is mainly focused on ...
Andreyev, Alexander Yu +11 more
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