Results 111 to 120 of about 444,349 (315)

Ectopic Adipose Tissue Storage in the Left and the Right Renal Sinus is Asymmetric and Associated With Serum Kidney Injury Molecule-1 and Fibroblast Growth Factor-21 Levels Increase

EBioMedicine, 2016
Objective: A potential mechanism by which obesity could promote hypertension and kidney diseases is through accumulation of adipose tissue in the renal sinus (RS).
Gita Krievina, MSc, Peteris Tretjakovs, Biol PhD, Ilze Skuja, MD, Vija Silina, MD, Laura Keisa, MD, Daiga Krievina, MSc, Guntis Bahs, MD PhD   +6 more
doaj   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

The role of endoplasmic reticulum in human adipose tissue [PDF]

Adipose tissue plays a central role in the regulation of metabolic homeostasis. In obesity adipocytes are challenged by many insults: surplus energy, inflammation, insulin resistance and considerable endoplasmic reticulum (ER) stress.
Alhusaini, S. (Saif)
core  

Determination of Pericardial Adipose Tissue Increases the Prognostic Accuracy of Coronary Artery Calcification for Future Cardiovascular Events [PDF]

, 2012
Objectives: Pericardial adipose tissue (PAT) is associated with coronary artery plaque accumulation and the incidence of coronary heart disease. We evaluated the possible incremental prognostic value of PAT for future cardiovascular events.
Ziegler, Franz von, Saam, Tobias, Steinbeck, Gerhard, Becker, Alexander, Hacker, Marcus, Greif, Martin, Leber, Alexander Wolfgang, Uebleis, Christopher, Rümmler, Janine, Arias-Herrera, Vivian, Becker, Christoph, D'Anastasi, Melvin   +11 more
core   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

Adipose tissue induction in vivo [PDF]

, 2006
Engineering adipogenic tissue in vivo requires the concomitant induction of angiogenesis to generate a stable long-term three-dimensional construct. Histiocon-ductive tissue engineering strategies have been used.
THOMPSON, E, Blondeel, P., Stillaert, F.B.J.L., MORRISON, WA, Abberton, K., Morrison, W.A., HAMDI, MOUSTAPHA, Hamdi, M., Thompson, E.W., ABBERTON, K, Stillaert, Filip, Blondeel, Phillip   +11 more
core   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Preeclampsia is associated with compromized maternal synthesis of long chain polyunsaturated fatty acids leading to offspring deficiency [PDF]

, 2012
Obesity and excessive lipolysis are implicated in preeclampsia (PE). Intrauterine growth restriction is associated with low maternal body mass index and decreased lipolysis.
Martin, I, Brown, E.A., Huda, S.S., Freeman, DJ, Jordan, F, Greer, I.A., Mackay, V.A., Brown, EA, Meyer, BJ, Tham, K, Meyer, B.J., Stewart, FM, McKenna, L.A., Huda, SS, Jordan, F., Mackay, VA, Hodson, L., Freeman, D.J., Tham, K., Martin, I., Greer, IA, Stewart, F.M., McKenna, LA, Hodson, Leanne, Hodson, L   +24 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling. [PDF]

, 2009
Calorie restriction (CR) and a reduced growth hormone (GH) signal affect insulin sensitivity and lifespan in mammals in a similar manner. We investigated the effects of CR and moderate inhibition of GH on glucose-stimulated activation of insulin ...
Park, Seongjoon, Trindade, Lucas Siqueira, Haruyoshi Yamaza, Isao Shimokawa, Yamaza, Haruyoshi, Shimokawa, Isao, Seongjoon Park, Lucas Siqueira Trindade, Hiroko Hayashi, Takuya Chiba, Komatsu, Toshimitsu, Hayashi, Hiroko, Chiba, Takuya, Toshimitsu Komatsu   +13 more
core   +1 more source