Results 101 to 110 of about 652,667 (264)

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

Ectopic Adipose Tissue Storage in the Left and the Right Renal Sinus is Asymmetric and Associated With Serum Kidney Injury Molecule-1 and Fibroblast Growth Factor-21 Levels Increase

EBioMedicine, 2016
Objective: A potential mechanism by which obesity could promote hypertension and kidney diseases is through accumulation of adipose tissue in the renal sinus (RS).
Gita Krievina, MSc, Peteris Tretjakovs, Biol PhD, Ilze Skuja, MD, Vija Silina, MD, Laura Keisa, MD, Daiga Krievina, MSc, Guntis Bahs, MD PhD   +6 more
doaj   +1 more source

Sirtuins 1–7 expression in human adipose-derived stem cells from subcutaneous and visceral fat depots: influence of obesity and hypoxia [PDF]

, 2016
The sirtuin family comprises seven NAD+-dependent deacetylases which control the overall health of organisms through the regulation of pleiotropic metabolic pathways.
Di Rocco, Giuliana, Mariani, Stefania, Petrangeli, Elisa, Russo, Matteo A., Salvatori, Luisa, Toietta, Gabriele   +5 more
core   +1 more source

Melt Electrowriting High Resolution Poly(ethylene‐co‐vinyl acetate) Scaffolds for Soft Tissue Engineering

Advanced Healthcare Materials, EarlyView.
This work pioneers melt electrowriting (MEW) of polyethylene vinyl acetate (PEVA) to fabricate ultra‐compliant, high‐resolution scaffolds. By integrating microscale precision with soft tissue‐like biomechanics, PEVA overcomes stiffness‐driven limitations of conventional MEW polymers, establishing a mechanically biomimetic platform for soft tissue ...
Finn Snow, Darcy De Rauch, Lilith Mabel Caballero Aguilar, Darcy Millett, Jasley Wilding McBride, David R Nisbet, Magdalena Kita, Elena Pirogova, Robert Michail Ivan Kapsa, Anita Quigley   +9 more
wiley   +1 more source

Offspring subcutaneous adipose markers are sensitive to the timing of maternal gestational weight gain [PDF]

, 2015
peer-reviewedBackground Excessive maternal weight gain during pregnancy impacts on offspring health. This study focused on the timing of maternal gestational weight gain, using a porcine model with mothers of normal pre-pregnancy weight.
Berry, Donagh, Blancher, Florence, Castaneda-Gutierrez, Euridice, Darimont, Christian, Giblin, Linda, Lawlor, Peadar G, Leone, Patricia, McNamara, Louise B.   +7 more
core   +1 more source

Diels‐Alder Click Chemistry as a Dynamic‐Covalent Crosslinking Method in Spheroid‐Encapsulating Hydrogels for Cartilage Engineering

Advanced Healthcare Materials, EarlyView.
This research shows the development of hydrogels with Diels‐Alder click chemistry for engineering cartilage‐like tissue. The hydrogels support cartilage spheroids which could be cultured for at least 28 days. Furthermore, the spheroids showed a tendency to fuse together into a more consistent construct, and produced important components needed for ...
Sanne M. van de Looij, Antonia G. Vasilopoulou, Lennard Spauwen, Antoinette van den Dikkenberg, Jasmijn V. Korpershoek, Mylene de Ruijter, Jos Malda, Bas G. P. van Ravensteijn, Tina Vermonden   +8 more
wiley   +1 more source

Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection [PDF]

, 2015
International audienceTwo of the crucial aspects of human immunodeficiency virus (HIV) infection are (i) viral persistence in reservoirs (precluding viral eradication) and (ii) chronic inflammation (directly associated with all-cause morbidities in ...
Avettand-Fenoël, Véronique, Benoist, Stéphane, Bourgeois, Christine, Béréziat, Véronique, Capeau, Jacqueline, Cosma, Antonio, Damouche, Abderaouf, David, Ludivine, Dejucq-Rainsford, Nathalie, Dereuddre-Bosquet, Nathalie, Favier, Benoît, Ghosn, Jade, Gommet, Céline, Huot, Nicolas, Lambotte, Olivier, Lazure, Thierry, Le Grand, Roger, Martinez, Valérie, Mélard, Adeline, Müller-Trutwin, Michaela, Noel, Nicolas, Pourcher, Guillaume, Rouzioux, Christine, Satie, Anne-Pascale, Vaslin, Bruno   +24 more
core   +6 more sources

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Molecular mechanism underlying nutritional control of inflammatory responses

Journal of Physical Fitness and Sports Medicine, 2017
Storage of excessive energy as triglycerides is a fundamental function of adipose tissue. Adipose tissue also secrets a number of hormones termed “adipocytokines” or “adipokines” in response to the systemic nutritional status, thereby constituting a ...
Miyako Tanaka, Takayoshi Suganami
doaj   +1 more source

Relationship between adipose tissue dysfunction, Vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease [PDF]

, 2017
Non-alcoholic fatty liver disease ( NAFLD) is the most common chronic liver disease worldwide. Its pathogenesis is complex and not yet fully understood.
BARCHETTA, ILARIA, BARONI, Marco Giorgio, BERTOCCINI, LAURA, CAROTTI, Simone, CAVALLO, Maria Gisella, CIMINI, FLAVIA AGATA, Morini, Sergio, VESPASIANI GENTILUCCI, UMBERTO   +7 more
core   +1 more source