Results 41 to 50 of about 261,601 (310)

Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

eLife, 2021
Cardiometabolic diseases are an increasing global health burden. While socioeconomic, environmental, behavioural, and genetic risk factors have been identified, a better understanding of the underlying mechanisms is required to develop more effective ...
Yi Liu, Nicolas Basty, Brandon Whitcher, Jimmy D Bell, Elena P Sorokin, Nick van Bruggen, E Louise Thomas, Madeleine Cule   +7 more
doaj   +1 more source

Inverse association of circulating SIRT1 and adiposity. A study on underweight, normal weight, and obese patients [PDF]

, 2018
Context: Sirtuins (SIRTs) are NAD+-dependent deacetylases, cellular sensors to detect energy availability, and modulate metabolic processes. SIRT1, the most studied family member, influences a number of tissues including adipose tissue.
Barbaro G, BASCIANI, Sabrina, CONTINI, SAVINA, DI GIORGIO, MARIA ROSARIA, Donini LM, Genco A, GNESSI, Lucio, Lenzi A, LUBRANO, Carla, MARIANI, Stefania, Persichetti A, Poggiogalle E, Rosano A, SAN MARTINI, Pietro, SARNICOLA, Antonio   +14 more
core   +1 more source

Cross-sectional associations between sleep duration, sedentary time, physical activity, and adiposity indicators among Canadian preschool-aged children using compositional analyses [PDF]

, 2017
Background Sleep duration, sedentary behaviour, and physical activity are three co-dependent behaviours that fall on the movement/non-movement intensity continuum.
AG LeBlanc, AL Adolph, B Day, BW Timmons, C Rich, Canadian Society for Exercise Physiology, CE Boeke, CJ Dobbelsteyn, DP Cliff, JNK Rao, KA Pfeiffer, KF Rust, L Matricciani, LL Moore, M Hirshkowitz, M Kang, Mark S. Tremblay, ME Rosenberger, MF Rolland-Cachera, ML Louzada, MP Buman, MS Tremblay, MS Tremblay, MS Tremblay, MS Tremblay, National Institutes of Health, RA Jones, RC Colley, RC Colley, RP Troiano, S Paruthi, Sebastien F. M. Chastin, SF Chastin, SL Wong, SM Williams, Statistics Canada, T Hinkley, V Carson, V Espana-Romero, Valerie Carson, WHO Multicentre Growth Reference Study Group, X Chen, Z Pedisic   +42 more
core   +4 more sources

Widely Used Commercial ELISA Does Not Detect Precursor of Haptoglobin2, but Recognizes Properdin as a Potential Second Member of the Zonulin Family

Frontiers in Endocrinology, 2018
BackgroundThere is increasing evidence for the role of impaired intestinal permeability in obesity and associated metabolic diseases. Zonulin is an established serum marker for intestinal permeability and identical to pre-haptoglobin2.
Lucas Scheffler, Alyce Crane, Henrike Heyne, Anke Tönjes, Dorit Schleinitz, Christian H. Ihling, Michael Stumvoll, Rachel Freire, Maria Fiorentino, Alessio Fasano, Peter Kovacs, John T. Heiker   +11 more
doaj   +1 more source

A five year longitudinal study investigating the prevalence of childhood obesity: comparison of BMI and waist circumference. [PDF]

, 2013
Objective: The purpose of this study was to examine the prevalence of obesity over time in the same individuals comparing body mass index (BMI), waist circumference (WC) and waist to height ratio (WHtR).
C. Griffiths, C.B. Cooke, Centre for Longitudinal Studies, Child Growth Foundation, Child Growth Foundation, Cole, Cowin, Falaschetti, Flodmark, Freedman, Freedman, Glasser, Goran, Griffiths, Janssen, Lohman, McCarthy, McCarthy, McCarthy, McCarthy, Mindell, National Institute for Health and Clinical Excellence, Neovius, Olds, P. Gately, P.R. Marchant, Power, Rasbash, Reilly, Rodriguez-Rodriguez, Savva, Schmidt, Summerbell, The NHS Information Centre, The NHS Information Centre, Wardle, Zimmet   +36 more
core   +1 more source

Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors

New England Journal of Medicine, 2011
Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults.We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided by the square of ...
Juonala, M, Magnussen, CG, Berenson, GS, Venn, A, Burns, TL, Sabin, MA, Srinivasan, SR, Daniels, SR, Davis, PH, Chen, W, Sun, C, Cheung, M, Viikari, JSA, Dwyer, T, Raitakari, OT   +14 more
openaire   +5 more sources

Memory function performance in individuals classified as overweight, obese, and normal weight

Frontiers in Nutrition, 2022
Evidence accumulated to date about the relationship between cognitive impairments and adults who are overweight and obese suggests that excess weight has a great impact on memory function. Nevertheless, most of the literature has focused only on studying
Marina Berbegal, Mario Tomé, Miriam Sánchez-SanSegundo, Ana Zaragoza-Martí, Ana Zaragoza-Martí, José Antonio Hurtado-Sánchez   +5 more
doaj   +1 more source

The Effect of Adiposity on Cardiovascular Function and Myocardial Fibrosis in Patients With Duchenne Muscular Dystrophy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Patients with Duchenne muscular dystrophy (DMD) develop cardiomyopathy because of a dystrophin deficiency causing fibrofatty replacement of the myocardium.
Sarah E. Henson, Sean M. Lang, Philip R. Khoury, Cuixia Tian, Meilan M. Rutter, Elaine M. Urbina, Thomas D. Ryan, Michael D. Taylor, Tarek Alsaied   +8 more
doaj   +1 more source

Undernutrition and stage of gestation influence fetal adipose tissue gene expression [PDF]

, 2015
Funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS), including the Strategic Partnership for Animal Science Excellence (SPASE) and the U.S. National Institutes of Health (HD045784).
Adam, Clare L, Aitken, Raymond P, Horgan, Graham W, Luther, Justin S, Milne, John S, Redmer, Dale A, Reynolds, Lawrence P., Wallace, Jacqueline M   +7 more
core   +1 more source

Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation

Molecular Metabolism, 2017
Objective: Several studies have demonstrated anti-diabetic and anti-obesogenic properties of visceral adipose tissue-derived serine protease inhibitor (vaspin) and so evoked its potential use for treatment of obesity-related diseases.
Juliane Weiner, Kerstin Rohde, Kerstin Krause, Konstanze Zieger, Nora Klöting, Susan Kralisch, Peter Kovacs, Michael Stumvoll, Matthias Blüher, Yvonne Böttcher, John T. Heiker   +10 more
doaj   +1 more source