Results 41 to 50 of about 261,971 (309)

Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

eLife, 2021
Cardiometabolic diseases are an increasing global health burden. While socioeconomic, environmental, behavioural, and genetic risk factors have been identified, a better understanding of the underlying mechanisms is required to develop more effective ...
Yi Liu, Nicolas Basty, Brandon Whitcher, Jimmy D Bell, Elena P Sorokin, Nick van Bruggen, E Louise Thomas, Madeleine Cule   +7 more
doaj   +1 more source

Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels. [PDF]

, 2020
Changes in fetal DNA methylation (DNAm) of the leptin (LEP) gene have been associated with exposure to maternal hyperglycemia, but their links with childhood obesity risk are still unclear.
Bouchard, Luigi, Breton, Edith, Cardenas, Andres, Fortin, Carol-Ann, Gagné-Ouellet, Valérie, Guérin, Renée, Hivert, Marie-France, Perron, Patrice, Thibeault, Kathrine   +8 more
core   +1 more source

THOC5: a novel gene involved in HDL-cholesterol metabolism[S]

Journal of Lipid Research, 2013
Although numerous genes are known to regulate serum lipid traits, identified variants explain only a small proportion of the expected heritability. We intended to identify further genetic variants associated with lipid phenotypes in a self-contained ...
Maria Keller, Dorit Schleinitz, Julia Förster, Anke Tönjes, Yvonne Böttcher, Antje Fischer-Rosinsky, Jana Breitfeld, Kerstin Weidle, Nigel W. Rayner, Ralph Burkhardt, Beate Enigk, Ines Müller, Jan Halbritter, Moritz Koriath, Andreas Pfeiffer, Knut Krohn, Leif Groop, Joachim Spranger, Michael Stumvoll, Peter Kovacs   +19 more
doaj   +1 more source

Reported and Recorded Sleepiness in Obesity and Depression

Frontiers in Psychiatry, 2020
BackgroundObesity and depression are both associated with changes in sleep/wake regulation, with potential implications for individualized treatment especially in comorbid individuals suffering from both.
Juliane Minkwitz, Juliane Minkwitz, Christian Sander, Hubertus Himmerich, Hubertus Himmerich, Julia Thormann, Julia Thormann, Tobias Chittka, Ulrich Hegerl, Ulrich Hegerl, Frank Schmidt, Monique Murray, Nihan Albayrak, Iain C. Campbell, Fabian Scheipl   +14 more
doaj   +1 more source

Ectopic cardiovascular fat in middle-aged men: effects of race/ethnicity, overall and central adiposity. The ERA JUMP study. [PDF]

, 2015
Background/objectivesHigher volumes of ectopic cardiovascular fat (ECF) are associated with greater risk of coronary heart disease (CHD). Identifying factors that are associated with ECF volumes may lead to new preventive efforts to reduce risk of CHD ...
Barinas-Mitchell, E, Budoff, M, Edmundowicz, D, El Khoudary, SR, El-Saed, A, ERA JUMP Study Group, Evans, RW, Fujiyoshi, A, Hisamatsu, T, Kadowaki, S, Kuller, LH, Masaki, K, Miura, K, Ohkubo, T, Sekikawa, A, Shin, C, Ueshima, H, Willcox, BJ   +17 more
core   +2 more sources

Women’s facial attractiveness is related to their body mass index, but not their salivary cortisol [PDF]

, 2015
Objectives: Although many theories of human facial attractiveness propose positive correlations between facial attractiveness and measures of actual health, evidence for such correlations is somewhat mixed.
Debruine, Lisa M., Fisher, Claire I., Hahn, Amanda C., Han, Chengyang, Jones, Benedict C.   +4 more
core   +2 more sources

Widely Used Commercial ELISA Does Not Detect Precursor of Haptoglobin2, but Recognizes Properdin as a Potential Second Member of the Zonulin Family

Frontiers in Endocrinology, 2018
BackgroundThere is increasing evidence for the role of impaired intestinal permeability in obesity and associated metabolic diseases. Zonulin is an established serum marker for intestinal permeability and identical to pre-haptoglobin2.
Lucas Scheffler, Alyce Crane, Henrike Heyne, Anke Tönjes, Dorit Schleinitz, Christian H. Ihling, Michael Stumvoll, Rachel Freire, Maria Fiorentino, Alessio Fasano, Peter Kovacs, John T. Heiker   +11 more
doaj   +1 more source

Evidence of fNIRS-Based Prefrontal Cortex Hypoactivity in Obesity and Binge-Eating Disorder

Brain Sciences, 2020
Obesity (OB) and associated binge-eating disorder (BED) show increased impulsivity and emotional dysregulation. Albeit well-established in neuropsychiatric research, functional near-infrared spectroscopy (fNIRS) has rarely been used to study OB and BED ...
Sarah A. Rösch, Ricarda Schmidt, Michael Lührs, Ann-Christine Ehlis, Swen Hesse, Anja Hilbert   +5 more
doaj   +1 more source

Memory function performance in individuals classified as overweight, obese, and normal weight

Frontiers in Nutrition, 2022
Evidence accumulated to date about the relationship between cognitive impairments and adults who are overweight and obese suggests that excess weight has a great impact on memory function. Nevertheless, most of the literature has focused only on studying
Marina Berbegal, Mario Tomé, Miriam Sánchez-SanSegundo, Ana Zaragoza-Martí, Ana Zaragoza-Martí, José Antonio Hurtado-Sánchez   +5 more
doaj   +1 more source

A five year longitudinal study investigating the prevalence of childhood obesity: comparison of BMI and waist circumference. [PDF]

, 2013
Objective: The purpose of this study was to examine the prevalence of obesity over time in the same individuals comparing body mass index (BMI), waist circumference (WC) and waist to height ratio (WHtR).
C. Griffiths, C.B. Cooke, Centre for Longitudinal Studies, Child Growth Foundation, Child Growth Foundation, Cole, Cowin, Falaschetti, Flodmark, Freedman, Freedman, Glasser, Goran, Griffiths, Janssen, Lohman, McCarthy, McCarthy, McCarthy, McCarthy, Mindell, National Institute for Health and Clinical Excellence, Neovius, Olds, P. Gately, P.R. Marchant, Power, Rasbash, Reilly, Rodriguez-Rodriguez, Savva, Schmidt, Summerbell, The NHS Information Centre, The NHS Information Centre, Wardle, Zimmet   +36 more
core   +1 more source