Results 51 to 60 of about 21,002 (290)

Protection against pertussis in humans correlates to elevated serum antibodies and memory B cells [PDF]

, 2017
Pertussis is a respiratory infection caused by Bordetella pertussis that may be particularly severe and even lethal in the first months of life when infants are still too young to be vaccinated. Adults and adolescents experience mild symptoms and are the
Carsetti, Rita, Di Mattia, G., Fedele, Giorgio, Frassanito, A., Gesualdo, Francesco, Leone, Pasqualina, Marcellini, Valentina, Midulla, Fabio, Mortari, Eva Piano, Nenna, R., Pandolfi, Elisabetta, Stefanelli, Paola, The Pertussis Study, Gropu, Tozzi, Alberto Eugenio   +13 more
core   +1 more source

Modified polyriboinosinic-polyribocytidylic acid, an immunological adjuvant [PDF]

Infection and Immunity, 1976
Stabilization of polyriboinosinic-polyribocytidylic acid against enzymatic hydrolysis by addition of poly-1-lysine and carboxymethylcellulose (PICLC) resulted in a compound with marked adjuvanticity. The primary antibody response of rhesus monkeys to formalin-inactivated Venezuelan equine encephalomyelitis virus vaccine was significantly potentiated if
E L Stephen, C L Crabbs, Hilton B. Levy, W E Houston   +3 more
openaire   +3 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

A model to study the impact of polymorphism driven liver-stage immune evasion by malaria parasites, to help design effective cross-reactive vaccines

Frontiers in Microbiology, 2016
Malaria parasites engage a multitude of strategies to evade the immune system of the host, including the generation of polymorphic T cell epitope sequences, termed altered peptide ligands (APLs).
Kirsty Lee Wilson, Sue Dong Xiang, Magdalena ePlebanski   +2 more
doaj   +1 more source

Allergic Rhinitis: What Do We Know About Allergen-Specific Immunotherapy?

Frontiers in Allergy, 2021
Allergic rhinitis (AR) is an IgE-mediated disease that is characterized by Th2 joint inflammation. Allergen-specific immunotherapy (AIT) is indicated for AR when symptoms remain uncontrolled despite medication and allergen avoidance. AIT is considered to
Tadech Boonpiyathad, Mongkol Lao-Araya, Chirawat Chiewchalermsri, Sasipa Sangkanjanavanich, Hideaki Morita, Hideaki Morita   +5 more
doaj   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Treg inducing adjuvants for therapeutic vaccination against chronic inflammatory diseases

Frontiers in Immunology, 2013
Many existing therapies in autoimmune diseases are based on systemic suppression of inflammation, the observed side effects illustrate the need for more specific interventions.
Chantal eKeijzer, Ruurd eVan Der Zee, Willem eVan Eden, Femke eBroere   +3 more
doaj   +1 more source

OM-85 BV for primary prevention of recurrent airway infections: a pilot randomized, double-blind, placebo-controlled study

Einstein (São Paulo), 2020
Objective To compare the frequency of respiratory tract infections in children treated with OM-85 BV and placebo during the 3-month therapy period, and observation for a further 3 months after treatment.
Fátima Cleonice de Souza, Magáli Mocellin, Renata Ongaratto, Lidiane Alves de Azeredo Leitão, Frederico Orlando Friedrich, Victória d’A Silveira, Marcelo Comerlato Scotta, Paulo Márcio Pitrez, Leonardo Araújo Pinto   +8 more
doaj   +2 more sources

Modulation of Functional Activities of Chicken Heterophils by Recombinant Chicken IFN-γ [PDF]

, 2001
The objective of the present studies was to examine the in vitro effects of recombinant chicken interferon-γ (rChIFN-γ) on shape change, phagocytosis, and the oxidative/nonoxidative killing activities of day-old chicken heterophils.
B. Kaspers, E.J. Pishko, HARMON B.G., K.C. Weining, KLEIN J.B., KOGUT M.H., KOGUT M.H., LEINO L., M.H. Kogut, MERRILL G.A., SETO F., STICKLE J.F., WEINING K.C.   +12 more
core   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source