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Vaccine adjuvants: mechanisms and platforms
Signal Transduction and Targeted Therapy, 2023 Adjuvants are indispensable components of vaccines. Despite being widely used in vaccines, their action mechanisms are not yet clear. With a greater understanding of the mechanisms by which the innate immune response controls the antigen-specific ...
Tingmei Zhao +6 more
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General characteristics of adjuvants and their mechanisms of action (part 2)
Биопрепараты: Профилактика, диагностика, лечение, 2021 One of the major public health challenges today is development of new vaccines and technologies to optimize the vaccination process. There is a growing scientific interest in vaccine adjuvants that enhance vaccine immunogenicity.
N. А. Alpatova +5 more
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Vaccine Potentiation by Combination Adjuvants
Vaccines, 2014 Adjuvants are crucial components of vaccines. They significantly improve vaccine efficacy by modulating, enhancing, or extending the immune response and at the same time reducing the amount of antigen needed. In contrast to previously licensed adjuvants,
Benoît Levast +5 more
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Local vaccination and systemic tumor suppression via irradiation and manganese adjuvant in mice [PDF]
arXiv, 2021 Presently 4T-1 luc cells were irradiated with proton under ultra-high dose rate FLASH or with gamma-ray with conventional dose rate, and then subcutaneous vaccination with or without Mn immuno-enhancing adjuvant into the mice for three times. One week later, we injected untreated 4T-1 luc cells on the other side of the vaccinated mice, and found that ...
arxiv
Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]
, 2008 Alum is used as a vaccine adjuvant and induces T<sub>h</sub>2 responses and T<sub>h</sub>2-driven antibody isotype production against co-injected antigens.
A. S. McKee +45 more
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Medicine in Drug Discovery, 2021 Adjuvants are essential components of vaccines that have been particularly effective at promoting protective humoral immunity to infectious diseases and preventing mortality and morbidity.
Zhenchuan Wu, Keqin Liu
doaj
Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants
Frontiers in Cellular and Infection Microbiology, 2021 Adjuvants are used to maximize the potency of vaccines by enhancing immune reactions. Components of adjuvants include pathogen-associated molecular patterns (PAMPs) and damage-associate molecular patterns (DAMPs) that are agonists for innate immune ...
Guang Han Ong +3 more
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Distinctive cellular response to aluminum based adjuvants. [PDF]
, 2020 Aluminum-based adjuvants (ABAs) are used in human vaccines to enhance the magnitude of protective immune responses elicited against specific pathogens.
Bondy, Stephen C +3 more
core
Nature Reviews Immunology, 2018 Besides cholesterol lowering, statins boost antigen presentation and adaptive immune responses, suggesting new uses as adjuvants for cancer immunotherapy.
openaire +2 more sources
The effect of diatomaceous earth in live, attenuated infectious bronchitis vaccine, immune responses, and protection against challenge. [PDF]
, 2017 Live virus vaccines are commonly used in poultry production, particularly in broilers. Massive application and generation of a protective local mucosal and humoral immunity with no adverse effects is the main goal for this strategy.
Corbeil, Lynette B +3 more
core +1 more source