Results 91 to 100 of about 26,392 (248)

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Late Antique Allāh: Ancestral Arabian Religion and the Monotheistic Zeitgeist

Arabian Archaeology and Epigraphy, EarlyView.
ABSTRACT This essay addresses the ongoing scholarly tension between the monotheistic interpretations of late pre‐Islamic Arabian religion, pioneered by G. Hawting and P. Crone, and the traditional accounts of rampant Arabian polytheism found in later Islamic literary sources.
Ahmad Al‐Jallad, Hythem Sidky
wiley   +1 more source

Physiologically based pharmacokinetic and toxicokinetic modeling: A multidisciplinary approach to drug development and ecotoxicology [PDF]

Hospital Pharmacology
Introduction: Physiologically based pharmacokinetic (PBPK) modeling is a powerful tool in pharmaceutical research and drug development, offering accurate predictions of drug absorption, distribution, metabolism, and elimination (ADME).
Todorović Nemanja B., Ćoškov Aleksandra D., Andrić Nebojša Lj., Stanić Bojana Đ., Milijašević Boris Ž., Milošević Nataša P., Janković Slobodan M., Lalić-Popović Mladena N.   +7 more
doaj   +1 more source

Second‐generation prokineticin PKR1 receptor agonists: Advancing cardioprotection against chemotherapy‐induced toxicity

British Journal of Pharmacology, EarlyView.
IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand, Simone Brogi, Mustafa Tezeren, Andrea Tafi, Omer H. Ocak, Hasan Koyuncu, Igor Tetko, Laurent Désaubry, Canan G. Nebigil   +8 more
wiley   +1 more source

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

Oxidative functionalization of triterpenes isolated from Euphorbia resinifera latex: Semisynthesis, ADME-Tox, molecular docking, and molecular dynamics simulations

, 2023
Imane Yamari, Ayoub Mouhib, Bouchra Es‐Sounni, Rida Nejjari, Noureddine Mazoir, Mohamed Bakhouch, Abdelkrim Mouzdahir, Ahmed Benharref, Mhammed El Kouali, Samir Chtita   +9 more
openalex   +1 more source

adm keuangan

, 2020
Dari beberapa kegiatan administrasi pendidikan, kegiatan yang menjadi salah satu unsur penting adalah Administrasi Anggaran/Biaya Pendidikan. Karena Biaya pendidikan merupakan salah satu komponen masukan instrumental (instrumental input) yang sangat penting dalam penyelenggaraan pendidikan (disekolah).
openaire   +1 more source

Identification of Quality Markers in Viola kunawaresis Royel Using HPLC Fingerprints, Chemometric Analysis, and Network Pharmacology

Biomedical Chromatography, Volume 40, Issue 4, April 2026.
ABSTRACT Violae tianshanicae herba (VTH), a widely used crude drug in Uyghur medicine in China, is renowned for its immunomodulatory, anti‐inflammatory, antibacterial, antiviral, and antidiabetic activities, with notable efficacy in treating asthma. However, systematic research on its quality markers (Q‐markers) remains limited, underscoring the need ...
Haifeng Liu, Rongmei Zhao, Hong Xu, Tabusi Manaer, Le Pan, Lu Jin, Amatjan Ayupbek   +6 more
wiley   +1 more source

An IQ Consortium Perspective on the FDA Guidance for Assessment of Pharmacokinetics in Participants With Impaired Renal Function

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 838-845, April 2026.
The FDA published guidance on assessing pharmacokinetics (PK) in participants with impaired renal function in 2024. The IQ CPLG Organ Impairment Working Group summarized the industry’s perspective on this guidance by highlighting a few key updates in the 2024 guidance, including: (1) the recommendation of using estimated glomerular filtration rate ...
Yan Jin, Ashish Sharma, Mariam A. Ahmed, Sravanthi Cheeti, Ying Ou, Damayanthi Devineni, Yizhe Chen, Jitendra S. Kanodia, Yasmeen Abouelhassan, Nadia Noormohamed, Jin Zhou, Patrick Marroum, Vaishali Sahasrabudhe, Islam R. Younis   +13 more
wiley   +1 more source

artikel adm

, 2020
Keberhasilansuatupendidikantidakhanyadilihatdarimanajemenkelas, kurikulum, murid dan sebagainya, tetapi juga manajemen personalia ikutberperandalamkeberhasilansuatupendidikan. Makadiperlukanmanajemen personalia (PTK). Dalampenelitianiniditemukanbahwaadatigaproses administrasi PTK yaitupenggandaan, penetapan, dan pembinaan.
openaire   +2 more sources