Results 111 to 120 of about 30,899 (248)

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

Recent Advances in ADME Predictions

, 2011
The basic objective of medicinal chemistry is to deliver not only potent in vitro chemicals, but also, more importantly, drug candidates that can be progressed to clinical trials and that will eventually reach the market. This is a long and winding road –
Gyorgy M. Keseru, Laszlo Molnar
core   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

ADME (Adsorption, Distribution, Metabolism, Excretion) properties of compounds.

, 2019
ADME (Adsorption, Distribution, Metabolism, Excretion) properties of compounds.
Xinhui Wang (126681), Weihang Li (6729335), Yang Bai (198601), Sheng Zhong (88247), Bo Wu (16141), Shanshan Jiang (382941), Jiaxin Ren (6729341), Rihua Jin (6729344), Yingjing Zhao (6729338), Hui Li (32376)   +9 more
core   +1 more source

adm keuangan

, 2020
Dari beberapa kegiatan administrasi pendidikan, kegiatan yang menjadi salah satu unsur penting adalah Administrasi Anggaran/Biaya Pendidikan. Karena Biaya pendidikan merupakan salah satu komponen masukan instrumental (instrumental input) yang sangat penting dalam penyelenggaraan pendidikan (disekolah).
openaire   +1 more source

Delafloxacin suppresses DEPDC1 expression and induces G2/M arrest in non‐small cell lung cancer cells: A drug repurposing study

Smart Molecules, EarlyView.
This study presents Delafloxacin repurposed as a DEPDC1‐targeting therapeutic aiming to suppress lung cancer progression. It highlights a novel strategy for lung cancer treatment with potential clinical applications. Abstract Emerging evidence highlights the oncogenic role of the Dishevelled, Egl‐10, and Pleckstrin domains containing 1 (DEPDC1) gene in
Noman Ali, Farishta Shafiq, Mishal Iftikhar, Muhammad Shahzad Zafar, Muhammad Shoaib   +4 more
wiley   +1 more source

Physiologically based pharmacokinetic and toxicokinetic modeling: A multidisciplinary approach to drug development and ecotoxicology [PDF]

Hospital Pharmacology
Introduction: Physiologically based pharmacokinetic (PBPK) modeling is a powerful tool in pharmaceutical research and drug development, offering accurate predictions of drug absorption, distribution, metabolism, and elimination (ADME).
Todorović Nemanja B., Ćoškov Aleksandra D., Andrić Nebojša Lj., Stanić Bojana Đ., Milijašević Boris Ž., Milošević Nataša P., Janković Slobodan M., Lalić-Popović Mladena N.   +7 more
doaj   +1 more source

adm konsep

, 2020
Administrasipendidikanmerupakan salah satubagiandari dunia pendidikankhususnya di lingkungansekolah. Administrasipendidikandiperlukandikarenakanadministrasipendidikanadalah proses memanfaatkan sumber daya pendidikan melalui kerja sama sejumlah orang dengan melaksanakan fungsi perencanaan, pelaksanaan, dan evaluasi, untuk mencapai ...
openaire   +2 more sources

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Natural antiviral flavonoids: Striking successful repurposing against COVID-19 through in-silico docking [PDF]

Journal of Stress Physiology & Biochemistry
Repurpose of recognized compounds and medications as anti-COVID 2019 (anti-CoVID-19) agents, in anti-SARS-CoV-2 operation, via biological re-assessment of their activities, is a recent and durable development for pandemic COVID-19 novel drugs in 2020 ...
Velayutham Gurunathan, Chidambaram Sathishkumar, Hariharan Govindasamy, Karumalaiyan Palanisamy, Periyanayagam Arockia Doss   +4 more
doaj