Results 131 to 140 of about 50,348 (248)

Accelerating Generic Long‐Acting Antiretrovirals for Global HIV Treatment: Workshop Findings and a Roadmap to Access

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1195-1204, May 2026.
The global HIV response aims for widespread availability of affordable, quality‐assured long‐acting antiretroviral (LA ARV) drugs to achieve sustained epidemic control, particularly in low‐ and middle‐income countries. This report summarizes key discussion points, findings, and outcomes from an international workshop on generic LA ARVs, held in ...
Usman Arshad, Lobna Gaayeb, Henry Pertinez, Rajith K. R. Rajoli, Melynda Watkins, Parag Nimbolkar, Simone Perazzolo, Bharat Pagi, Annemarie Wensing, Saye Khoo, Marta Boffito, René Holm, Zack Panos, Imelda Mahaka, Francois Venter, Benny Kottiri, Keith W. Crawford, Rodney J. Y. Ho, Polly Clayden, Paul Domanico, Kimberly Struble, Andrew Owen, Charles Flexner   +22 more
wiley   +1 more source

Tetrandrine, a Major Alkaloid From Stephaniae Tetrandrae Radix, Ameliorates Non‐Alcoholic Fatty Liver Disease in Zebrafish via the PI3K/AKT/STAT3 Pathway

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Tet regulates lipid metabolism and cell apoptosis to alleviate NAFLD. Integrated network pharmacology, Mendelian randomization, and experimental validation demonstrate that Tet activates the PI3K/AKT/STAT3 signaling axis, suppresses apoptosis, reduces hepatic lipid accumulation, and improves biochemical liver injury markers, supporting its potential as
Peng Sun, Jun Wu, Kai Ma, Xiaoli Wei, Jing Ma, Wenhao Han, Xiaoyu Zhu, Xinyu Zhang, Xi Wang, Tangnuer Tuersunniyazi, Wei Gong, Hong Lin   +11 more
wiley   +1 more source

How to integrate in vitro PK/PD information for toxicity prediction [PDF]

, 2009
Predicting drugs' in vivo effects from in vitro testing requires modelling processes that are not reproduced by in vitro systems. The most obvious difference between the two situations is the absence of the absorption, distribution, metabolism, and ...
Bois, Frédéric Y.
core   +1 more source

Neuroprotective Effects of Carnosine Against Corticosterone‐Induced Depression and Memory Impairment

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
This main findings of the study and illustrates the key workflow. ABSTRACT Corticosterone (Crt) is reported to induce oxidative stress in experimental animals. Carnosine (Crn), a well‐known dipeptide antioxidant synthesized endogenously from β‐alanine and L‐histidine, neutralizes oxidative stress. The current study examines the influences of Crn on Crt‐
Muneezah Elahi, Noreen Samad, Ali Irfan, Natasha Manzoor, Muhammad Zeeshan Ahmed, Emilio Mateev, Yousef A. Bin Jardan   +6 more
wiley   +1 more source

Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations. [PDF]

, 2018
Interactions of drug molecules with lipid membranes play crucial role in their accessibility of cellular targets and can be an important predictor of their therapeutic and safety profiles.
Bekker, Slava, Clancy, Colleen E, DeMarco, Kevin R, Noskov, Sergei Y, Vorobyov, Igor   +4 more
core  

Antennaria dioica (L.) Gaertn. (Asteraceae): From Metabolite Profiling to Comprehensive Evaluation of In Vitro and In Silico Enzyme Inhibitory Activity

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Antennaria dioica (L.) Gaertn. is a perennial herb from the tribe Gnaphalieae of the Asteraceae family. In‐depth phytochemical profiling and in vitro antioxidant and enzyme inhibition assessment of methanol‐aqueous extract from the A. dioica aerial parts were integrated with molecular docking study.
Dimitrina Zheleva‐Dimitrova, Gokhan Zengin, Iglika Lessigiarska, Ivanka Tsakovska, Radostina Nikolova‐Kejova, Ivayla Zheleva‐Kyuchukova, Georgi Momekov, Reneta Gevrenova   +7 more
wiley   +1 more source

Natural antiviral flavonoids: Striking successful repurposing against COVID-19 through in-silico docking [PDF]

Journal of Stress Physiology & Biochemistry
Repurpose of recognized compounds and medications as anti-COVID 2019 (anti-CoVID-19) agents, in anti-SARS-CoV-2 operation, via biological re-assessment of their activities, is a recent and durable development for pandemic COVID-19 novel drugs in 2020 ...
Velayutham Gurunathan, Chidambaram Sathishkumar, Hariharan Govindasamy, Karumalaiyan Palanisamy, Periyanayagam Arockia Doss   +4 more
doaj  

Pharmacological Evaluation of Methanolic Fruit Extract of Lannea coromandelica: Antioxidant, Cytotoxic, Antidiabetic, Antibacterial, Anti‐Inflammatory, and Sedative Activities

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Phytochemical investigation of Lannea coromandelica through GC–MS and in silico analysis revealed diverse bioactive compounds with promising pharmacological potential. Integrated in vitro and in vivo assays demonstrated significant antioxidant, antidiabetic, antibacterial, anti‐inflammatory, and sedative activities, supporting its therapeutic relevance.
Priota Islam Meem, Zobayed Islam, Nazmul Hasan Eshaque, Md. Jahirul Islam Mamun, Khurram Murad Mojidee, Mohammad Badrudduja, Amit Kumar Dam, S. M. Moazzem Hossen   +7 more
wiley   +1 more source

adm supervisi

, 2020
Supervisi pendidikan adalahusaha memberi layanan kepada guru-guru baik secara individual maupun secara kelompok dalam usaha memperbaiki pengajaran. Kata kunci dari pemberi supervisi pada akhirnya ialah memberikan pelayanan dan bantuan. Ruang lingkup dari supervisi pendidikan adalah akademik dan managerial.
openaire   +2 more sources

The Evolving Therapeutic Landscape of Gallic Acid: A Review of Mechanistic Insights and Clinical Potential

Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.
ABSTRACT Gallic acid (GA), a plant‐derived phenolic compound, is evolving from a general antioxidant into a specific molecular modulator and a functional building block for advanced biomedical materials. This review synthesizes recent insights underpinned by GA's “redox duality”—its capacity to act as either a radical scavenger or a pro‐oxidant.
Woo Hyun Park
wiley   +1 more source