Results 141 to 150 of about 30,899 (248)
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.ABSTRACT Drug repurposing presents a cost‐effective and time‐efficient strategy to identify new therapeutic applications for existing drugs. Recent advances in artificial intelligence, including machine learning, deep learning, knowledge graphs, and natural language processing, have revolutionized this field by enabling automated discovery of drug ...
Alaba Bukola Ogungbite, Malusi Sibiya
wiley +1 more source
Solubility, Delivery and ADME Problems of Drugs and Drug-Candidates
, 2011 This comprehensive ebook covers all the aspects of ADME/PK modeling including solubility, absorption, formulation, metabolic stability, drug-drug interaction potential and a special delivery tool of drug candidates.
core +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.ABSTRACT This work aims to assess the S65487‐induced disruption of the B‐cell lymphoma‐2 (Bcl2)/Bcl2‐like protein 11 (Bim) complex at therapeutic doses via a pharmacokinetic/pharmacodynamic model and to reconcile pharmacokinetic data from microdoses and therapeutic doses in a single population pharmacokinetic model. The first model consists of a linear
Chloé Burlot +6 more
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Refined ADME Profiles for ATC Drug Classes
Background: Modern generative chemistry initiatives aim to produce potent and selective novel synthetically feasible molecules with suitable pharmacokinetic properties.
Ricard Garcia-Serna +5 more
core +1 more source
, 2016 ADME (absorption, distribution, metabolism, elimination) has rapidly evolved over the past two decades, creating a unique interdisciplinary interface between medicinal chemists, biologists, formulators, toxicologists, clinicians, and regulators across ...
Hartung, Thomas +2 more
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, 2020 Supervisi pendidikan adalahusaha memberi layanan kepada guru-guru baik secara individual maupun secara kelompok dalam usaha memperbaiki pengajaran. Kata kunci dari pemberi supervisi pada akhirnya ialah memberikan pelayanan dan bantuan. Ruang lingkup dari supervisi pendidikan adalah akademik dan managerial.
openaire +2 more sources
ChemMedChem, Volume 21, Issue 11, 15 June 2026.In this work, we identified two novel pleiotropic sinapic acid derivatives with excellent anti‐acetylcholinesterase, antioxidant, and anti‐inflammatory properties. Alzheimer's disease, one of the most widespread neurodegenerative disorders, is known for its multifactorial nature that makes it challenging to treat.
Konstantina Sdougkou +2 more
wiley +1 more source
4-Hydroxyisoleucine as a Natural DPP-4 Inhibitor for Diabetes
Biology, Medicine & Natural Product ChemistryResearch on 4-hydroxyisoleucine, a natural compound found in several plant sources, shows potential as an antidiabetic agent through inhibiting the DPP-4 (dipeptidyl peptidase-4) enzyme.
Amir Thalib, Irma Putri Damayanti
doaj +1 more source
ChemSusChem, Volume 19, Issue 11, 15 June 2026.Highly selective deuteration is now possible with a green and more environmentally benign reaction protocol for Cu‐catalyzed transfer hydrodeuteration of alkenes and alkynes. This was applied to the synthesis of precisely deuterated alkanes, including deuterated complex molecules and high enantiopurity isotopomers. Precisely labeled small molecules are
Aniel J. Rivera Arzola +5 more
wiley +1 more source
In the peculiar manner by which physicists reckon descent, this article is by a "child" and "grandchild" of the late Stanley Deser. We begin by sharing reminiscences of Stanley from over 40 years. Then we turn to a problem which was dear to his heart: the prospect that gravity might nonperturbatively screen its own ultraviolet divergences and those of ...
Woodard, R. P., Yesilyurt, B.
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