Results 141 to 150 of about 26,232 (247)

<i>Syzygium aromaticum</i> Attenuates Cerebellar Oxidative Stress: An Integrated in silico, in vitro, and in vivo Evaluation of Multi-Target Antioxidant Mechanisms. [PDF]

J Exp Pharmacol
Etukudo EM, Usman IM, Oviosun A, Ojiakor VO, Makena W, Owembabazi E, Aja PM, Anyanwu E.   +7 more
europepmc   +1 more source

Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Bioactive peptides (BAPs) derived from host, marine, insect, plant and synthetic sources share cationic, amphipathic structures adopting α‐helical, β‐sheet or cyclic conformations. These features underlie anti‐cancer effects, including membrane disruption, apoptosis and cell‐cycle arrest, anti‐metastatic activity, reduced invasion and migration, and ...
Najwa Doha, Richa Gill, Sergio Crovella, Haissam Abou‐Saleh, Sahar Isa Da'as   +4 more
wiley   +1 more source

Cathepsin L in cancer: Context‐dependent functions, microenvironmental regulation and translational opportunities

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Cathepsin L (CTSL) acts as a context‐dependent facilitator of tumour progression rather than a universal oncogenic driver. CTSL's pro‐tumorigenic functions are critically evaluated alongside its inherent biochemical constraints and family‐wide redundancy. CTSL‐related biology may provide translational opportunities in selected contexts.
Yujun Wu, Qin Huang, Zixuan Ding, Lin Fu, Mu Yang, Bi Peng, Pengbo Hu, Yuanhui Liu   +7 more
wiley   +1 more source

Gaps in AI-Driven Pharmacokinetic Property Prediction for Early Drug Development: A Scoping Review. [PDF]

J Chem Inf Model
Tomin L, Bodaghi-Namileh V, Schwartz DG, Samudrala R, Falls Z.   +4 more
europepmc   +1 more source

Pharmacokinetics and Acute Safety Evaluation of Tryptanthrin, A Bioactive Constituent of Indigo naturalis, Following Intravenous Administration in Mice

Journal of Applied Toxicology, Volume 46, Issue 10, Page 3498-3505, October 2026.
ABSTRACT The use of Indigo naturalis in treating inflammatory diseases is clinically restricted by severe adverse events, including pulmonary arterial hypertension and hepatotoxicity. Tryptanthrin, a major indoloquinazoline alkaloid of Indigo naturalis, exhibits potent anti‐inflammatory activity; however, its specific safety profile relative to the ...
Hyung Jin Kim, Gabsik Yang, Jun Ho Lee
wiley   +1 more source

Mechanistic Prediction of Maternal, Fetal, and Amniotic Fluid Betamethasone Concentrations to Support Dosing Optimization in Pregnancy

The Journal of Clinical Pharmacology, Volume 66, Issue 10, October 2026.
Abstract Respiratory distress syndrome (RDS) remains a major cause of neonatal mortality following premature birth. Antenatal betamethasone is the standard of care to accelerate fetal lung maturation and improve neonatal outcomes; however, current dosing recommendations assume uniform maternal and fetal exposure across pregnancies. Gestational age (GA)‐
Alaa Mahdi, Khaled Abduljalil, Fernanda de Lima Moreira, Hiral Raju Mehta, Jhohann Richard de Lima Benzi, Alessandra Cristina Marcolin, Stephan Schmidt, Natalia V. de Moraes   +7 more
wiley   +1 more source

Explainable Multi-Isoform QSAR, PubChem Concordance, and Applicability-Domain-Guided Prioritization of Selective Human Carbonic Anhydrase I, II, IX, and XII Inhibitors. [PDF]

Pharmaceuticals (Basel)
Elsayad AM, Elsayad KA.
europepmc   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

A Metabolism-Guided Framework for Selecting Structural Modification or Nano-Delivery Strategies for Oral Rutin. [PDF]

Int J Mol Sci
He T, Wang Y, Yan F, Fan BS, Fu RJ, Xu DQ, Yang J, Tang YP.   +7 more
europepmc   +1 more source

Synthesis and Cytotoxic Activity of 1,3‐Selenazole‐2‐Amine Derivatives With Computational ADMET Profiling

ChemistryOpen, Volume 15, Issue 10, October 2026.
Four novel 1,3‐selenazole‐2‐amine derivatives were synthesized and evaluated in HT‐29, MCF‐7, and L929 cell lines. Compound 4 showed the highest MCF‐7 cytotoxicity. Compound 3 displayed low L929 toxicity. In silico ADMET predicted favorable pharmacokinetic properties.
Gulay Dilek, Senem Akkoc
wiley   +1 more source