Results 141 to 150 of about 50,348 (248)

Sustainable Ethanol‐Based Reversed‐Phase Liquid Chromatography for Determination of Diltiazem pKa and Quantification with Integrated Green and White Analytical Metrics

open access: yesChemistryOpen, Volume 15, Issue 5, May 2026.
A sustainable reversed‐phase liquid chromatography method is developed for diltiazem analysis and pKadetermination. The study integrates green and white analytical chemistry frameworks to evaluate environmental impact and practicality. The Environmental, Performance, and Practicality Index is utilized as a comprehensive, holistic tool for the ...
Zehra Üstün   +2 more
wiley   +1 more source

Contaminants of emerging concern in agricultural soils: Current understanding, overlooked issues, and future priorities

open access: yesPLANTS, PEOPLE, PLANET, Volume 8, Issue 3, Page 792-810, May 2026.
Contaminants of emerging concern (CECs) in agriculture represent a growing global challenge for food safety and public health. In this review, we synthesized evidence on how substances such as pharmaceuticals, microplastics, and per‐ and polyfluoroalkyl substances (PFAS) enter soils, accumulate in crops, and affect ecological and human health. We found
Laura J. Carter   +8 more
wiley   +1 more source

4-Hydroxyisoleucine as a Natural DPP-4 Inhibitor for Diabetes

open access: yesBiology, Medicine & Natural Product Chemistry
Research on 4-hydroxyisoleucine, a natural compound found in several plant sources, shows potential as an antidiabetic agent through inhibiting the DPP-4 (dipeptidyl peptidase-4) enzyme.
Amir Thalib, Irma Putri Damayanti
doaj   +1 more source

Machine Learning Meets Pharmacokinetics: A Comparative Analysis of Predictive Models for Plasma Concentration‐Time Profiles

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Predicting pharmacokinetic (PK) profiles from molecular structures represents a significant advancement in pharmaceutical research with substantial implications for expediting drug discovery processes. We evaluated five approaches to systematically compare five distinct methodological frameworks for predicting rat plasma concentration‐time ...
Felix Jost   +4 more
wiley   +1 more source

The Other ADM

open access: yes
In the peculiar manner by which physicists reckon descent, this article is by a "child" and "grandchild" of the late Stanley Deser. We begin by sharing reminiscences of Stanley from over 40 years. Then we turn to a problem which was dear to his heart: the prospect that gravity might nonperturbatively screen its own ultraviolet divergences and those of ...
Woodard, R. P., Yesilyurt, B.
openaire   +3 more sources

Intestinal Organoid‐Based Mathematical Modeling Predicts Clinical Gastrointestinal Toxicity of Oral Oncology Drugs

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Gastrointestinal (GI) toxicity is a common and potentially severe side effect of antiproliferative cancer therapies that often requires dose reduction or treatment interruption. Despite the clinical implications, there are currently no robust strategies for quantitative preclinical assessment of GI toxicity.
Carmen Pin   +7 more
wiley   +1 more source

Safety of beta‐nicotinamide mononucleotide (β‐NMN) pursuant the regulation (EU) 2015/2283 and the bioavailability of nicotinamide from this source in the context of Directive 2002/46/EC

open access: yesEFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on beta‐nicotinamide mononucleotide (β‐NMN) as a novel food (NF) pursuant to Regulation (EU) 2015/2283, including an evaluation of the safety of its use in food supplements as a source of niacin ...
EFSA Panel on Nutrition   +28 more
wiley   +1 more source

Safety of L‐alpha‐glycerylphosphorylcholine (L‐alpha‐GPC) from soya phospholipids (lecithin) as a novel food pursuant to Regulation (EU) 2015/2283

open access: yesEFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on L‐alpha‐glycerylphosphorylcholine (L‐alpha‐GPC) as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition   +27 more
wiley   +1 more source

Safety of oil from Schizochytrium sp. A2 for use in infant and follow‐on formula as a novel food pursuant to regulation (EU) 2015/2283

open access: yesEFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of an oil derived from the microalga‐like organism Schizochytrium sp. A2 as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition   +22 more
wiley   +1 more source

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