Results 141 to 150 of about 24,681 (243)

Assessing the impact of data harmonization on human liver microsomal stability prediction model performance. [PDF]

Results Chem
Weber C, Xu X, Shah P.
europepmc   +1 more source

Chemical Profiles, Pharmacological Insights, and In Silico Studies of Antidesma montanum Blume: An Experimental and Computer‐Aided Approach

eFood, Volume 7, Issue 4, August 2026.
Antidesma montanum, an edible wild plant, shows notable nutraceutical and pharmacological potential. Methanol extract profiling (GC–MS) identified bioactive metabolites. In vitro, in vivo, and in silico studies demonstrated significant antidiabetic, anthelmintic, anxiolytic, antidepressant, and antidiarrheal activities, supported by strong molecular ...
Naureen Banu, Najmul Alam, Sadia Farid Jhuma, Mohammad Nazmul Islam, Shady A. Alghazali, Md Abdul Awal, Sanjida Islam, Hafsa Siddiqua, Shafinaz Nur, Md. Sohel Rana   +9 more
wiley   +1 more source

Knowledge Discovery and Drug-Repurposing Framework for Pancreatic Ductal Adenocarcinoma: Molecular Networking and Computational Docking. [PDF]

Comput Struct Biotechnol J
Corbo T, Graarud EP, Resell M, Kalajdzic A, Pojskic N, Chen D, Gustafsson BI, Zhao CM.   +7 more
europepmc   +1 more source

Wild Daucus carota Subsp. maximus: Phytochemicals, Bioactivities, and Pharmacokinetic Insights for Future Food and Therapeutic Applications

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Wild Daucus carota subsp. Maximus: chemical investigation and biological assessment. ABSTRACT Daucus carota subsp. maximus, a biennial plant from the Apiaceae family, is valued for its aromatic properties. It is the largest wild carrot subspecies found in Algeria, characterized by its tall stem, triangular leaves, and large umbels.
Maroua Hadji, Khadidja Dehimi, Fethi Farouk Kebaili, Tahar Smaili, Toka Hadji, Larbi Derbak, Ilyas Yildiz, Fehmi Boufahja, Hamdi Bendif, Tarek H. Taha, Walid Elfalleh, Stefania Garzoli   +11 more
wiley   +1 more source

Computational Discovery and Optimization of a Potent, Selective, and Drug-Like Scaffold for p38α Inhibition. [PDF]

Drug Des Devel Ther
Nelen J, Goettert MI, Forster M, Breuils L, Villalgordo-Soto JM, Laufer S, Pérez-Sánchez H.   +6 more
europepmc   +1 more source

Integrative GC–MS, FT‐IR, and Molecular Docking Analysis of Drimycarpus racemosus (Roxb.) Hook.f ex Marchand: In Vivo Analgesic and Antidiabetic Potential

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
GC–MS profiling of D. racemosus identified bioactive phytochemicals with promising molecular interactions through docking analysis. The methanolic extract demonstrated significant antinociceptive activity against acetic acid‐ and formalin‐induced pain and exhibited antidiabetic effects in streptozotocin‐induced diabetic Swiss albino mice, supporting ...
Md Sajib Ali, Md. Rakibul Islam, M. A. Rafi, Sanjana Haque Esha, Md. Mehedi Hasan, Payar Hossain, Abdullah Ripon, Nilufar Sultana   +7 more
wiley   +1 more source

Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines. [PDF]

Arch Toxicol
Ravi Shankar AL, Irwan J, Spaenig M, Carlier M, Hansen T, Zumbülte N, Islam B, Lundquist P, Svensson R, Gouin T, Hamers T, Escher SE.   +11 more
europepmc   +1 more source

The Influence of Applied Voltage on Drying Kinetics, Quality, and Mathematical Modeling of Ginger During Electrohydrodynamic (EHD) Drying

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
The graphical abstract systematically outlines the experimental design and major findings of this study. On the left is the conventional natural air‐drying method used as the control group; the middle section illustrates the Electrohydrodynamic (EHD) drying process under voltage gradients of 13, 17, and 21 kV, followed by four analytical dimensions ...
Mingyu Ding, Jingli Lu
wiley   +1 more source

Conocarpan and Eupomatenoid-6 as Natural Prototypes for Antituberculosis Compounds. [PDF]

Int J Microbiol
Silva LL, Ramos AVG, Baldoqui DC, de Souza Santos NC, Siqueira VLD, Caleffi-Ferracioli KR, Cardoso RF, da Silva RZ, de Lima Scodro RB.   +8 more
europepmc   +1 more source

Microbiome‐Phytochemical Crosstalk Along the Gut‐Brain Axis in Alzheimer and Parkinson's Disease

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Phytochemicals remodel the gut microbiota by enriching beneficial bacteria and microbial metabolites while suppressing dysbiosis and inflammation. Through modulation of the gut–brain axis, they restore intestinal barrier integrity, regulate neuroimmune and neuroprotective signaling pathways, reduce amyloid‐β, tau, and α‐synuclein pathology, and ...
Md. Emon, Md. Mizanur Rahaman, Dhrubo Sarder, Md. Shadin, Shamima Akter Neela, Phurpa Wangchuk, Subir Sarker   +6 more
wiley   +1 more source