Results 151 to 160 of about 50,348 (248)

Design, Synthesis, and Evaluation of New Polyhydroxylated Bis‐Chalcones as Potential COX‐2 Selective Inhibitors

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Novel polyhydroxylated bis‐chalcones were successfully synthesized and demonstrated COX‐2 selective inhibition. The most potent and selective inhibitor exhibited a mixed‐type inhibition mechanism with COX‐2. Its additional bulk preferentially blocked the access to the active pocket of COX‐1 rather than COX‐2. Selective inhibition of COX‐2 is considered
Rui Pereira, Alberto N. Araújo, Daniela Ribeiro, Ismael Rufino, Nuno Martinho, Rita C. Guedes, Vera L. M. Silva, Eduarda Fernandes   +7 more
wiley   +1 more source

adm pendidikan

, 2019
Abstract — Educational Administration in Teaching Profession is an educational activity to develop capabilities in the field of administration. science, learning theory and skills implemented long-term aim that is for administrative staff, management or develop the knowledge that has been learned and practiced at school Soekarto Indrafachrudi (2006: 57-
openaire   +2 more sources

Design, Synthesis, and Biological Evaluation of Novel Triazine‐Based Dual Histone Deacetylase/phosphatidylinositol 3‐kinase Inhibitors for Breast Cancer Therapy

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Breast cancer is the most frequently diagnosed malignancy and a leading cause of cancer‐related mortality among women worldwide. Triple‐negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive nature, limited therapeutic options, and high propensity for drug resistance.
Lara Luzietti, Gustavo Salgado Pires, Ana Ryan, Crisamie Regidor, Matthew Hiller, Danilo Sarti, Tríona Ní Chonghaile, Pedro de Sena Murteira Pinheiro, Damir Varešlija, Daniel Alencar Rodrigues   +9 more
wiley   +1 more source

ADME Parameters

Charts of ADME ...
openaire   +1 more source

ADM [PDF]

Chemical & Engineering News Archive, 1960
openaire   +1 more source

It is all About “ADME” [PDF]

Advances in Chronic Kidney Disease, 2016
openaire   +2 more sources

GC-MS, Antibacterial and In silico Studies of Sudanese Acacia polyacantha Stem Bark Alcoholic Extract

Journal of Experimental Pharmacology
Abubakr A Hammad,1,2 Abdelgadir A Abdelgadir,2,3 Sitelbanat Yassin,4 Abdulrahim A Alzain,5 Elhadi M Ahmed2,3 1Department of Pharmacognosy, Faculty of Pharmacy, Omdurman Islamic University, Omdurman, Sudan; 2Department of Pharmacognosy, Faculty of ...
Hammad AA, Abdelgadir AA, Yassin S, Alzain AA, Ahmed EM   +4 more
doaj  

Next-Generation Artificial Intelligence for ADME Prediction in Drug Discovery: From Small Molecules to Biologics. [PDF]

Yonago Acta Med
Tanihata S, Iwata H.
europepmc   +1 more source

Role of Structural, Pharmacokinetic, and Energy Properties in the High-Throughput Prediction of Redox Potentials for Organic Molecules with Experimental Calibration. [PDF]

ACS Omega
Kalia A, Porokhin V, Blackburn B, Alba R, Ajo-Franklin C, Mevers E, Hassoun S.   +6 more
europepmc   +1 more source

Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines. [PDF]

Arch Toxicol
Ravi Shankar AL, Irwan J, Spaenig M, Carlier M, Hansen T, Zumbülte N, Islam B, Lundquist P, Svensson R, Gouin T, Hamers T, Escher SE.   +11 more
europepmc   +1 more source