Results 151 to 160 of about 24,681 (243)

Peer review of the pesticide risk assessment of the active substance cinmethylin. [PDF]

EFSA J
European Food Safety Authority (EFSA), Álvarez F, Arena M, Auteri D, Leite SB, Binaglia M, Castoldi AF, Chiusolo A, Colagiorgi A, Colas M, Crivellente F, De Lentdecker C, De Magistris I, Egsmose M, Fait G, Ferilli F, Santonja GG, Gouliarmou V, Halling K, Ippolito A, Istace F, Kardassi D, Kienzler A, Lanzoni A, Lava R, Leuschner R, Linguadoca A, Romano ML, Louisse J, Lythgo C, Magrans O, Mangas I, Mazzega S, Mioč A, Miron I, Molnar T, Padovani L, Padricello V, Panzarea M, Parra Morte JM, Rizzuto S, Santos M, Serafimova R, Sharp R, Szentes C, Theobald A, Tiramani M, Vianello G, Villamar-Bouza L, Athanasiou D.   +49 more
europepmc   +1 more source

In Vivo Evaluation of Psoralen in a Copper Sulfate–Induced Chick (Gallus gallus domesticus) Emesis Model and In Silico Analysis of Its Interaction With D2, 5‐HT3A, and Muscarinic Receptors

ChemistryOpen, Volume 15, Issue 8, August 2026.
Psoralen (PSN) demonstrates significant dose‐dependent antiemetic activity in a copper sulfate–induced chick emesis model. Integrated in vivo and in silico analyses reveal reduced retching frequency, prolonged latency, and favorable multi‐receptor interactions with D2, 5‐HT3A, and muscarinic receptors, highlighting PSN as a promising multi‐target ...
Kishor Chandra, Sharif Uddin Bahar, Khadija Akter, Mst Muslima Khatun, Samiran Sadhukhan, Progna Saha Puja, Fazley Rohan, Md Shimul Bhuia, Mohammed Alfaifi, Faisal H. Altemani, Faisal Alsenani, Salehin Sheikh, Muhammad Torequl Islam   +12 more
wiley   +1 more source

<i>In silico</i> evaluation of soursop (<i>Annona muricata</i>) leaf compound interactions with CYP450 and their potential impact on systemic cancer therapies. [PDF]

Toxicol Rep
Ballesteros-Ramírez R, Fuenmayor D, Martínez-Ramos N, Duque-Grisales E, Murillo R.   +4 more
europepmc   +1 more source

Development of a Disease‐Specific Virtual Malaria Population for Physiologically‐Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Malaria remains a major global health challenge, with an urgent need for new therapies to combat the evolving resistance to anti‐malarial treatments. Physiologically‐based pharmacokinetic (PBPK) modeling offers a promising approach to accurately predict PK, optimize dosing strategies, reduce development time and cost, and de‐risk the ...
Junjie Ding, Qi Pei, Richard M. Hoglund, Joel Tarning   +3 more
wiley   +1 more source

Developmentally dynamic chromatin state at loci regulating organ crosstalk by remote sensing and signaling. [PDF]

Epigenetics Chromatin
Parmar A, Nigam SK, Cai K, Falah K, Ermakov VS, Wang K, Ferguson CJ.   +6 more
europepmc   +1 more source

A Physiologically Based Pharmacokinetic Model to Predict Potential Drug–Drug Interactions of TPN171, a Novel Phosphodiesterase Type 5 Inhibitor

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT TPN171 is a potent phosphodiesterase type 5 inhibitor used to treat pulmonary arterial hypertension and erectile dysfunction, primarily metabolized by CYP3A4. This study aimed to evaluate its drug–drug interaction (DDI) potential and determine the optimal dosing when co‐administered with CYP3A4 modulators.
Guanghui Tian, Tao Chen, Lei Li, Zhiqiang Wang, Hao Yang, Jiaxiang Juan, Yuanqin Duan, Jianghong Pei, Jingying Jia   +8 more
wiley   +1 more source

NPASS database update 2026: comprehensive quantitative composition, bioactivity, and ADME-Tox data of natural products for biomedical research. [PDF]

Nucleic Acids Res
Lin H, Hou D, Jiang X, Yin R, Yu S, Lu S, Wang S, Ju D, Zhao H, Chen Y, Zeng X.   +10 more
europepmc   +1 more source

DDIapp—A Web‐Based Application for Static Drug–Drug Interaction Assessment

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT In this work we describe the development of a web‐based application for static drug–drug interaction (DDI) risk assessment in accordance with the International Council for Harmonization (ICH) M12 guidance. The app was built using the Shiny for Python framework and it employs a modular mathematical modeling structure that incorporates models ...
Hirotaka Watase, Sylvie Klieber, Yorgos M. Psarellis, Nikhil Pillai, Panteleimon D. Mavroudis, Saroj Dhakal   +5 more
wiley   +1 more source

Multivariate analysis and ADME profiling of <i>Rosmarinus officinalis</i> L. leaf vs. stem extracts: Extraction method-driven bioactivity and pharmacokinetic implications. [PDF]

Biochem Biophys Rep
Ed-Darraz FZ, Tayibi S, Mounaimi S, Hbika A, Boufetacha M, Lyamlouli K, Barakat A, Gharibi EK.   +7 more
europepmc   +1 more source

Physiologically Based Pharmacokinetic Model of Brigatinib in Healthy Volunteers and Patients With Cancer

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Brigatinib, an oral ALK inhibitor for metastatic NSCLC, lacks dosing guidance for special populations such as the Chinese. This study developed a physiologically based pharmacokinetic (PBPK) model using European data from patients with hepatic/renal impairment and drug–drug interaction (DDI) studies (itraconazole, rifampin). The model was then
Yichao Xu, Xinhua Hu, Pengfei Zhao, Lu Wang, Zourong Ruan, Bo Jiang, Honggang Lou   +6 more
wiley   +1 more source