Results 171 to 180 of about 24,681 (243)

Pufferfish exposure and presumed tetrodotoxicosis in Australian dogs: 372 cases (2007–2018)

Australian Veterinary Journal, Volume 104, Issue 8, Page 497-508, August 2026.
Introduction Tetrodotoxin (TTX) is a neurotoxin found in pufferfish that results in the blockade of excitatory conduction and clinical signs including gastrointestinal upset and paralysis. The objectives of this study were to describe the epidemiology of pufferfish exposure and presumed tetrodotoxicosis in dogs, and to determine associations with the ...
J Hanson, CR Sharp, EM Leister
wiley   +1 more source

Antibacterial and Anticancer Potential of <i>Alhagi maurorum</i> Ethanol Crude Extract: LC-MS-Guided Evidence and In Silico Mechanistic Insights. [PDF]

Int J Mol Sci
Mahdi IM, Najm AAK.
europepmc   +1 more source

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez‐Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +13 more
wiley   +1 more source

ADME related patterns to predict the prognosis and immune therapy of colon cancer patients. [PDF]

Sci Rep
Liu Y, Liu J, Tu X, Nie J, Li H, Yu G.
europepmc   +1 more source

Multi‐Omics‐Guided Design and Safety Engineering of Nucleic Acid Therapeutics: From Molecular Perturbation to Predictive Toxicology and Precision Translation

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Multi‐omics (proteomics, metabolomics, and single‐cell/spatial transcriptomics) provides a systems framework to distinguish on‐target efficacy from off‐target and toxicity signatures of chemically modified nucleic acid therapeutics, enabling omics‐guided structure–activity and safety optimisation from discovery to clinical translation. ABSTRACT Nucleic
Gurjit Kaur Bhatti, Anushka Verma, Komal Devi, Naina Khullar, Inderpal Singh Sidhu, Umesh Chand Singh Yadav, Jasvinder Singh Bhatti   +6 more
wiley   +1 more source

Improving ADME Prediction with Multitask Graph Neural Networks and Assessing Explainability in Lead Optimization. [PDF]

J Chem Inf Model
Ito S, Koyama T, Matsumoto S, Kojima R, Okamoto Y, Kuroda M, Kawashima H, Watanabe R, Yonezawa T, Sumiyoshi T, Ikeda K, Mizuguchi K, Iwata H, Okuno Y.   +13 more
europepmc   +1 more source

Liquid Chromatography–Tandem Mass Spectrometry Quantification of Diet‐Derived CYP2D6 Biomarkers for Clinical Phenotyping in Japanese Subjects

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT The enzymatic activity of cytochrome P450 2D6 (CYP2D6) exhibits substantial interindividual variation, which influences drug efficacy and the risk of adverse drug reactions to various therapeutics. While current protocols for CYP2D6 genotyping or CYP2D6 phenotyping provide useful information, less invasive and simpler tools are desirable for ...
Masaki Kumondai, Nagomi Hayashi, Yotaro Matsumoto, Akiko Ebata, Miku Sato, Narumi Harada‐Shoji, Hiroshi Tada, Minoru Miyashita, Takanori Ishida, Masamitsu Maekawa, Yoshihisa Tomioka, Nariyasu Mano   +11 more
wiley   +1 more source

Artificial intelligence in drug discovery from advanced molecular representation to pipeline applications. [PDF]

Front Bioinform
Zhou X, Tao W.
europepmc   +1 more source

Exploring the neuroprotective, antioxidant, and anti-amyloid effects of Ganoderma lucidum compounds in Alzheimer's disease: insights from experimental and computational approaches. [PDF]

J Genet Eng Biotechnol
Mia M, Dutta A, Hossain MM, Adhikari J, Rahman MM, Shibly AZ.   +5 more
europepmc   +1 more source

Bridging the Pregnancy Knowledge Gap: A Real‐World Analysis of Medication Use and Drug–Drug Interaction Risk in Crohn's Disease and Multiple Sclerosis

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT The exclusion of pregnant individuals from clinical trials has resulted in a significant medical knowledge gap for this population. Leveraging real‐world data (RWD) provides a critical window into the prevalence and use of medications during pregnancy.
Jacqueline Williams, Rucha Sane, Amita Joshi, Kit Wun Kathy Cheung, Bianca Vora   +4 more
wiley   +1 more source