Results 161 to 170 of about 26,232 (247)

Synthesis, anti-proliferative evaluation, DFT, <i>in silico</i> ADME and molecular modeling studies of novel imidazolones as potential EGFR inhibitors. [PDF]

RSC Adv
Hekal MH, Abdel-Megid M, Salem ME, Alrashdi S, Alzahrani AYA, Abu El-Azm FSM.   +5 more
europepmc   +1 more source

Novel Flavonoid Senotherapeutics Identified by Phenotypic Drug Discovery Reduce Senescence and Improve Multiple Markers of Healthspan

Aging Cell, Volume 25, Issue 10, October 2026.
Phenotypic screening and SAR‐guided drug design identified two flavonoid‐derived senolytics, SR29384 and SR31133, which selectively killed different types of senescent cells more efficiently and with greater selectivity than fisetin in culture. In aged and progeroid mice, these fisetin analogs reduced tissue senescence and improved physical function ...
Lei Justan Zhang, Rahagir Salekeen, Carolina Soto‐Palma, Qiuming Wu, Yuanjun He, Osama Elsallabi, Bilel Bdiri, Brian Hughes, Allancer Nunes, Wandi Xu, Borui Zhang, Abdalla Mohamed, Sara J. McGowan, Luise Angelini, Ryan O'Kelly, Theodore M. Kamenecka, Laura J. Niedernhofer, Paul D. Robbins   +17 more
wiley   +1 more source

Scientific Opinion on waiving of the dog studies in the regulatory process of agrochemicals approval. [PDF]

EFSA J
EFSA Panel on Plant Protection Products and their Residues (PPR), Coja T, Adriaanse P, Finizio A, Giraudo M, Kuhl T, McVey E, Metruccio F, Paparella M, Pieper S, Scanziani E, Teodorovic I, Van der Brink P, Wilks M, Hernandez-Jerez A, Pelkonen O, Terron A, Louisse J, Panzarea M, Scattareggia Marchese A, Choi J.   +20 more
europepmc   +1 more source

Vitamins and Chronic Wounds: How Altered Pharmacokinetics and Comorbidities Contribute to Vitamin Deficiencies

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Wound healing is complex and requires adequate amounts of macro‐ and micronutrients. When wound healing is delayed, a wound is considered chronic. Increasing evidence shows that vitamin deficiencies are prevalent in patients with chronic wounds, yet intervention studies with vitamin supplementation yielded inconsistent effects.
Michiel G. J. Balvers, Teuntje L. de Smit, Anne I. Slotegraaf, Remy H. H. Bemelmans, Joé L. P. Kolkert, Tim J. Schuijt, Renger F. Witkamp   +6 more
wiley   +1 more source

In Vitro Experimental and Computational Studies of the Vasorelaxant Effects of Quinazolin-4(3<i>H</i>)-one and Its Interaction with α1-Adrenergic Receptors. [PDF]

Curr Issues Mol Biol
Rhazi Y, Bouadid I, Guerguer F, El Mesky M, Lamssane H, Nakkabi A, Bakhouch M, Qattan MY, Alkubaisi NA, Chtita S, Aboul-Soud MAM, Giesy JP, El Yazidi M, Eddouks M.   +13 more
europepmc   +1 more source

Therapeutic potential of a Bax inhibitor‐1/TMBIM6 antagonist (BIA) and its analogues in Aspergillus fumigatus‐induced asthma via dual targeting of AKT and epithelial‐derived inflammatory cytokines

British Journal of Pharmacology, Volume 183, Issue 19, Page 5975-5991, October 2026.
Background and Purpose Aspergillus fumigatus (A. fumigatus) exposure causes of severe allergic asthma, characterized by airway inflammation and epithelial dysfunction. TMBIM6 (Bax inhibitor‐1) has been implicated in airway epithelial stress responses and AKT signalling.
Young‐Jin Yu, Ahsan Ullah, Jisun Kim, Mehedi Hasan Bappi, Yerim Heo, Jin Hee Ahn, Hyun‐Kyoung Kim, Han‐Jung Chae   +7 more
wiley   +1 more source

Triazole‐Linked Pyrimidine Nucleoside Dimers: Design, Synthesis, and Applications in Medicinal and Nucleic Acid Chemistry. Part IV

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
A series of 18 pyrimidine nucleoside dimers analogues with a short 1,4‐disubstituted 1,2,3‐triazole linkage were synthesized using a click chemistry approach (CuAAC). Analysis of the obtained products was conducted utilizing 1D/2D NMR spectroscopy (1H, 13C, 19F, 15N, and 29Si), mass spectrometry (ESI‐MS), and high‐performance liquid chromatography ...
Dagmara Baraniak, Dariusz Wawrzyniak, Daniel Baranowski   +2 more
wiley   +1 more source

Hit-To-Lead Optimization of a Pyridylpiperazine Class Against Malaria: Pharmacokinetic Profile and In Vivo Efficacy of Optimized Compounds. [PDF]

ChemMedChem
Oliveira DDDS, Pereira DE, Chelucci RC, Michelan S, Pituba JMF, Andricopulo AD, Ferreira LLG, Silva NM, Júnior COR.   +8 more
europepmc   +1 more source

Translational PBPK Modeling and Exposure‐Response Analysis of AT‐RvD1 for Treating Sjögren's Disease

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Sjögren's disease (SD) is an autoimmune condition characterized by chronic inflammation and impaired secretory function of the salivary glands (SG). The proresolving lipid mediator AT‐RvD1 restores SG function in SD‐like mice; however, its tissue pharmacokinetics, exposure‐response relationships, and human dose predictions remain poorly ...
Venkata K. Yellepeddi, Kihoon Nam, Frank M. Maslow, Olga J. Baker   +3 more
wiley   +1 more source