Results 121 to 130 of about 30,899 (248)

Late Antique Allāh: Ancestral Arabian Religion and the Monotheistic Zeitgeist

Arabian Archaeology and Epigraphy, EarlyView.
ABSTRACT This essay addresses the ongoing scholarly tension between the monotheistic interpretations of late pre‐Islamic Arabian religion, pioneered by G. Hawting and P. Crone, and the traditional accounts of rampant Arabian polytheism found in later Islamic literary sources.
Ahmad Al‐Jallad, Hythem Sidky
wiley   +1 more source

In Silico Analysis of Ocimum Basilicum Flavonoids as Natural Antihypertensive Agent on Angiotensin II Type-1 Receptor (AT1R)

Biology, Medicine & Natural Product Chemistry
Despite the efficacy of antihypertensive medications like ARBs, their adverse effects frequently result in suboptimal adherence. This study investigates the efficacy of flavonoids obtained from herbal sources as natural substitutes for traditional ...
Amir Thalib, Irma Putri Damayanti
doaj   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Docking-MM-GB/SA and ADME screening of HIV-1 NNRTI inhibitor: Nevirapine and its analogues

, 2008
Nevirapine and its synthetic analogues, a class of non-nucleoside inhibitors (NNRTIs) of HIV-1 reverse transcriptase (RT), have been the objective of numerous studies focused to prepare better and safer anti-HIV drugs.
Verma, D., Sengupta, D., Naik, P.K.
core  

Evaluation of combustion AMS “MICADAS” for ADME studies

, 2017
Today, combustion AMS (accelerator mass spectrometry) technology, such as "MICADAS", is considered to enable completion of the human ADME study much earlier and, as a consequence, might represent an opportunity to change the current drug development ...
Fahrni, Simon, Walles, Markus, Welte, Caroline, Lozac'H, Frederic, Pearson, David, Camenisch, Gian P., Synal, Hans-Arno, De Maria, Daniele   +7 more
core   +1 more source

Study of ADME characteristics of thioderivatives of 3,5-bis(5-mercapto-4-R-4H-1,2,4-triazol-3-yl)phenol

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
This study investigates the ADME properties of newly synthesized derivatives of 3,5-bis(5-mercapto-4-R-4H-1,2,4-triazol-3-yl)phenols and their alkylated analogues.
K. K. Isaicheva, A. H. Kaplaushenko
doaj   +1 more source

Comparative Pharmacokinetics of Six Bioactive Constituents From Danggui Jixueteng Decoction in Normal and Myelosuppressive Rats

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT This study compared the pharmacokinetics of six constituents from Danggui Jixueteng Decoction in normal versus carboplatin‐induced myelosuppressive rats. A rapid, sensitive ultra‐high performance liquid chromatography‐tandem mass spectrometry method was developed and validated for simultaneous quantification of six diverse constituents (8‐O ...
Mingxin Guo, Yingjie Liu, Zhiqiang Hu, Xiayu Liu   +3 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

DNA templates & comparator assays for analysis of ADME SNPs.

, 2017
DNA templates & comparator assays for analysis of ADME SNPs.
Alison Velyian Todd (3692239), Elisa Mokany (1268727), Tina Lonergan (3692245), Nicole Elizabeth Lima (3692242), Samantha Michelle Walker (3692236), Lit Yeen Tan (3692233)   +5 more
core   +1 more source

Virtual Based Screening of Rosmaniric Acid and Its Derivatives as Potential Anticancer Approach Targeting HIF-1a

Biotropika: Journal of Tropical Biology
Cancer is one of the leading causes of death in the world. Rosmarinic acid becomes one of the important polyphenolic compounds. It includes derivatives of two amino acids, caffeic acid from phenylalanine and 3,4-dihydroxyphenyl-lactic acid from tyrosine,
Achmad Hanif Naufal, Nisa Nabila Aufa Wachid, Fairuz Sarah Kamila, Nadia Wahyuningsih, Silvi Zakiyatul Ilmiyah, Wirdatun Nafisah, Fatchiyah Fatchiyah   +6 more
doaj   +1 more source