Results 1 to 10 of about 2,416,358 (290)

Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms

Drug Design, Development and Therapy, 2022
Jinghui Wang,1 Yuhua Zhang,2 Meifeng Zhang,1 Si Sun,1 Yang Zhong,1 Lei Han,1 Yitong Xu,1 Dong Wan,3 Junhui Zhang,4 Huifeng Zhu1 1College of Pharmaceutical Sciences & College of Chinese Medicine, Southwest University, Chongqing, 400715, People’s Republic ...
Wang J, Zhang Y, Zhang M, Sun S, Zhong Y, Han L, Xu Y, Wan D, Zhang J, Zhu H   +9 more
doaj   +2 more sources

Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications

Pharmaceutics, 2023
Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways.
Raquel Taléns-Visconti, Jesus Vicente de Julián-Ortiz, Ofelia Vila-Busó, Octavio Diez-Sales, Amparo Nácher   +4 more
doaj   +2 more sources

Intranasal administration of dantrolene increased brain concentration and duration.

PLoS ONE, 2020
Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent.
Jintao Wang, Yun Shi, Shuchun Yu, Yan Wang, Qingcheng Meng, Ge Liang, Maryellen F Eckenhoff, Huafeng Wei   +7 more
doaj   +2 more sources

Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs.

PLoS ONE, 2020
Intranasal ketamine has recently gained interest in human medicine, not only for its sedative, anaesthetic or analgesic properties, but also in the management of treatment resistant depression, where it has been shown to be an effective, fast acting ...
Lise Vlerick, Mathias Devreese, Kathelijne Peremans, Robrecht Dockx, Siska Croubels, Luc Duchateau, Ingeborgh Polis   +6 more
doaj   +2 more sources

First-in-human intranasal [13N]oxytocin PET: evaluation of feasibility, biodistribution, and radiation dosimetry [PDF]

EJNMMI Research
Background Oxytocin is a neuropeptide with therapeutic potential for several neuropsychiatric and pain-related disorders. Intranasal delivery is proposed to enable access to the central nervous system via the trigeminal nerve and olfactory nerves ...
Michael Winterdahl, Erik Nguyen Nielsen, Søren B. Hansen, André Henrique Dias, Mikkel Holm Vendelbo, Steen Jakobsen, David Yeomans   +6 more
doaj   +2 more sources

Intranasal creatine administration increases brain creatine level and improves Barnes maze performance in rats

Brain Research Bulletin, 2023
While skeletal muscle creatine levels can be enhanced by exogenous creatine supplementation, the elevation of brain creatine levels with oral creatine administration remains a challenge due to a lack of effective transportation of creatine through the ...
Kaiqing Chen, Xiaoping Hu
doaj   +1 more source

Effects of multiple-dose intranasal oxytocin administration on social responsiveness in children with autism: a randomized, placebo-controlled trial

Molecular Autism, 2023
Background Intranasal administration of oxytocin is increasingly explored as a new approach to facilitate social development and reduce disability associated with a diagnosis of autism spectrum disorder (ASD).
N. Daniels, M. Moerkerke, J. Steyaert, A. Bamps, E. Debbaut, J. Prinsen, Tiffany Tang, S. Van der Donck, B. Boets, K. Alaerts   +9 more
semanticscholar   +1 more source

Utility of a Novel Micro-Spraying Device for Intranasal Administration of Drug Solutions to Mice

Pharmaceutics, 2023
Intranasal administration has attracted attention as a means of delivering drugs because it bypasses the blood–brain barrier. However, conventional intranasal administration of drug solutions to mice using the micropipette method (MP method) is ...
Naoto Suzuki, Hiroaki Tanigawa, Taiki Nagatomo, Hiroko Miyagishi, Takanori Kanazawa, Toyofumi Suzuki, Yasuhiro Kosuge   +6 more
doaj   +1 more source

The nose has it: Opportunities and challenges for intranasal drug administration for neurologic conditions including seizure clusters

Epilepsy & Behavior Reports, 2022
Nasal administration of treatments for neurologic conditions, including rescue therapies to treat seizure clusters among people with epilepsy, represents a meaningful advance in patient care.
Steve S. Chung, J. Peters, K. Detyniecki, W. Tatum, A. Rabinowicz, E. Carrazana   +5 more
semanticscholar   +1 more source

Effects of Intranasal Administration of Oxytocin and Vasopressin on Social Cognition and Potential Routes and Mechanisms of Action

Pharmaceutics, 2022
Acute and chronic administration of intranasal oxytocin and vasopressin have been extensively utilized in both animal models and human preclinical and clinical studies over the last few decades to modulate various aspects of social cognition and their ...
S. Yao, K. Kendrick
semanticscholar   +1 more source