Results 11 to 20 of about 96,743 (331)

Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications

Pharmaceutics, 2023
Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways.
Raquel Taléns-Visconti, Jesus Vicente de Julián-Ortiz, Ofelia Vila-Busó, Octavio Diez-Sales, Amparo Nácher   +4 more
doaj   +2 more sources

Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms

Drug Design, Development and Therapy, 2022
Jinghui Wang,1 Yuhua Zhang,2 Meifeng Zhang,1 Si Sun,1 Yang Zhong,1 Lei Han,1 Yitong Xu,1 Dong Wan,3 Junhui Zhang,4 Huifeng Zhu1 1College of Pharmaceutical Sciences & College of Chinese Medicine, Southwest University, Chongqing, 400715, People’s Republic ...
Wang J, Zhang Y, Zhang M, Sun S, Zhong Y, Han L, Xu Y, Wan D, Zhang J, Zhu H   +9 more
doaj   +2 more sources

Intranasal administration of dantrolene increased brain concentration and duration.

PLoS ONE, 2020
Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent.
Jintao Wang, Yun Shi, Shuchun Yu, Yan Wang, Qingcheng Meng, Ge Liang, Maryellen F Eckenhoff, Huafeng Wei   +7 more
doaj   +2 more sources

Effects of Intranasal Orexin-A (Hypocretin-1) Administration on Neuronal Activation, Neurochemistry, and Attention in Aged Rats

Frontiers in Aging Neuroscience, 2020
Cognitive function represents a key determinative factor for independent functioning among the elderly, especially among those with age-related cognitive disorders.
Coleman B. Calva, Habiba Fayyaz, Jim R. Fadel   +2 more
doaj   +2 more sources

Effects of multiple-dose intranasal oxytocin administration on social responsiveness in children with autism: a randomized, placebo-controlled trial

Molecular Autism, 2023
Background Intranasal administration of oxytocin is increasingly explored as a new approach to facilitate social development and reduce disability associated with a diagnosis of autism spectrum disorder (ASD).
N. Daniels, M. Moerkerke, J. Steyaert, A. Bamps, E. Debbaut, J. Prinsen, Tiffany Tang, S. Van der Donck, B. Boets, K. Alaerts   +9 more
semanticscholar   +1 more source

Effects of Intranasal Administration of Oxytocin and Vasopressin on Social Cognition and Potential Routes and Mechanisms of Action

Pharmaceutics, 2022
Acute and chronic administration of intranasal oxytocin and vasopressin have been extensively utilized in both animal models and human preclinical and clinical studies over the last few decades to modulate various aspects of social cognition and their ...
S. Yao, K. Kendrick
semanticscholar   +1 more source

Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants

Signal Transduction and Targeted Therapy, 2022
The outbreak of coronavirus disease 2019 (COVID-19) has posed great threats to global health and economy. Several effective vaccines are available now, but additional booster immunization is required to retain or increase the immune responses owing to ...
H. Lei, Aqu Alu, Jingyun Yang, Wen-hui Ren, Cai He, Tianxia Lan, Xuemei He, Li Yang, Jiong Li, Zhenling Wang, Xiangrong Song, Wei Wang, G. Lu, Xiawei Wei   +13 more
semanticscholar   +1 more source

Pharmacokinetics of Cannabidiol Following Intranasal, Intrarectal, and Oral Administration in Healthy Dogs

Frontiers in Veterinary Science, 2022
The therapeutic potential of cannabidiol (CBD), a non-psychtropic component of the Cannabis sativa plant, is substantiated more and more. We aimed to determine the pharmacokinetic behavior of CBD after a single dose via intranasal (IN) and intrarectal ...
D. Polidoro, R. Temmerman, M. Devreese, Marios Charalambous, L. Ham, I. Cornelis, B. Broeckx, P. Mandigers, Andrea Fischer, J. Storch, S. Bhatti   +10 more
semanticscholar   +1 more source

Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients

Pharmaceutics, 2022
As a mental disease in modern society, depression shows an increasing occurrence, with low cure rate and high recurrence rate. It has become the most disabling disease in the world.
Zhiyu Jin, Yu Han, Dan-shen Zhang, Zhongqiu Li, Yongshuai Jing, Beibei Hu, Shiguo Sun   +6 more
semanticscholar   +1 more source

Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge

Vaccines, 2021
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective prophylactic vaccination to prevent the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
R. King, A. Silva-Sánchez, Jessica N. Peel, David Botta, A. Dickson, Amelia K. Pinto, S. Meza-Perez, S. Allie, Michael D. Schultz, Mingyong Liu, J. Bradley, S. Qiu, Guang Yang, Fen Zhou, Esther Zumaquero, Thomas S. Simpler, B. Mousseau, J. Killian, B. Dean, Q. Shang, J. Tipper, Christopher A Risley, K. Harrod, Tsungwei Feng, Y. Lee, B. Shiberu, Vyjayanthi Krishnan, I. Peguillet, Jianfeng Zhang, T. Green, T. Randall, J. Suschak, B. Georges, J. Brien, F. Lund, M. Roberts   +35 more
semanticscholar   +1 more source