Results 21 to 30 of about 96,743 (331)

Intranasal Administration of RBD Nanoparticles Confers Induction of Mucosal and Systemic Immunity against SARS-CoV-2

Vaccines, 2021
Mucosal immunity plays a significant role in host defense against viruses in the respiratory tract. Because the upper respiratory airway is a primary site of SARS-CoV-2 entry, immunization at the mucosa via the intranasal route could potentially lead to ...
Tuksin Jearanaiwitayakul, Mathurin Seesen, R. Chawengkirttikul, Jitra Limthongkul, Suttikarn Apichirapokey, S. Sapsutthipas, S. Phumiamorn, P. Sunintaboon, S. Ubol   +8 more
semanticscholar   +1 more source

Essential Oil-Loaded NLC for Potential Intranasal Administration [PDF]

Pharmaceutics, 2021
Complementary and alternative medicines represent an interesting field of research on which worldwide academics are focusing many efforts. In particular, the possibility to exploit pharmaceutical technology strategies, such as the nanoencapsulation, for the delivery of essential oils is emerging as a promising strategy not only in Italy but also all ...
Angela Bonaccorso, Cinzia Cimino, Daniela Erminia Manno, Barbara Tomasello, Antonio Serra, Teresa Musumeci, Giovanni Puglisi, Rosario Pignatello, Claudia Carbone   +8 more
openaire   +4 more sources

Intranasal administration of regulatory dendritic cells is useful for the induction of nasal mucosal tolerance in a mice model of allergic rhinitis

World Allergy Organization Journal, 2020
Background: Intranasally administered dendritic cells (DCs) migrate into blood and thymus to induce immune responses. Regulatory dendritic cells (DCs) are also useful agents for allergy control.
Motohiko Suzuki, Makoto Yokota, Yoshihiro Kanemitsu, Wei-Ping Min, Shinya Ozaki, Yoshihisa Nakamura   +5 more
doaj   +1 more source

Effect of Administration Route on the Pharmacokinetics of Cobalamin in Elderly Patients: A Randomized Controlled Trial

Current Therapeutic Research, 2014
Background: The gold standard for cobalamin deficiency treatment is administration of cobalamin by intramuscular injection. The injection is painful and inconvenient, particularly for elderly persons.
Monique P.H. Tillemans, PharmD, Eline M.V.J. Donders, MD, Sjoerd L. Verweij, PharmD, Ruud T.M. Van der Hoeven, PharmD, Kees J. Kalisvaart, MD, PhD   +4 more
doaj   +1 more source

A Compensatory Liability Regime to Promote the Exchange of Microbial Genetic Resources for Research and Benefit Sharing [PDF]

, 2011
Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules ...
Andersen, Hanne, Buonaguro, Franco M., Buonaguro, Luigi, Hinkula, Jorma, Lewis, Mark, Pal, Ranajit, Schroeder, Ulf, Tagliamonte, Maria, Torneselloa, Maria Lina, Visciano, Maria Luisa, Wahren, Britta   +10 more
core   +2 more sources

Comparative evaluation of two intranasal forms of Curcumin: Quantitation and impact on mouse model of asthma

Phytomedicine Plus, 2023
Aim of the study: Present study aimed to investigate impact of two different intranasal forms of curcumin on mouse model of asthma and detection of its absorption after different time points of administration.
Payal Singh, Ruchi Chawla, Ajai Kumar Pandey, J.K. Mishra, Rashmi Singh   +4 more
doaj   +1 more source

Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]

, 2003
The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Couet, William, Dufès, Christine, Gaillard, Afsaneh, Gaillard, Frédéric, Muller, Jean-Marc, Olivier, Jean-Christophe   +5 more
core   +3 more sources

Pharmacokinetic Study of Intranasal Dexamethasone and Methylprednisolone Compared with Intravenous Administration: Two Open-Label, Single-Dose, Two-Period, Two-Sequence, Cross-Over Study in Healthy Volunteers

Pharmaceutics, 2022
Dexamethasone (DXM) and methylprednisolone (MEP) are potent glucocorticoids used to control several inflammatory conditions. Evidence of delayed DXM reaching the central nervous system (CNS) as well as tachyphylaxis and systemic, undesirable side effects
Graciela Cárdenas, Raúl J. Bobes, Gladis Fragoso, Nicolas I. Pérez-Osorio, Marisela Hernández, Alejandro Espinosa, Agnes Fleury, José Flores, The Revival Project Consortium, Juan Pedro Laclette, Edda Sciutto, Helgi Jung-Cook   +11 more
doaj   +1 more source

Inhaled Insulin: Intrapulmonary or Intranasal? [PDF]

, 2012
Initial attempts delivered the insulin hormone intramuscularly, intravenously, and eventually subcutaneously. Other routes of administration of the drug were explored.
Danish Ahmed, Shivangi Jaiswal, Shruti Mishra, Sweta Kumari   +3 more
core   +2 more sources

Shortcut Approaches to Substance Delivery into the Brain Based on Intranasal Administration Using Nanodelivery Strategies for Insulin

Molecules, 2020
The direct delivery of central nervous system (CNS) drugs into the brain after administration is an ideal concept due to its effectiveness and non-toxicity.
T. Tashima
semanticscholar   +1 more source