Results 51 to 60 of about 96,743 (331)

Pharmacometric Modeling of the Impact of Azelastine Nasal Spray on SARS-CoV-2 Viral Load and Related Symptoms in COVID-19 Patients

Pharmaceutics, 2022
The histamine-1 receptor antagonist azelastine was recently found to impact SARS-CoV-2 viral kinetics in a Phase 2 clinical trial (CARVIN). Thus, we investigated the relationship between intranasal azelastine administrations and viral load, as well as ...
Christiane Dings, Peter Meiser, Frank Holzer, Michael Flegel, Dominik Selzer, Eszter Nagy, Ralph Mösges, Jens Peter Klussmann, Thorsten Lehr   +8 more
doaj   +1 more source

Comparing the immune response to a novel intranasal nanoparticle PLGA vaccine and a commercial BPI3V vaccine in dairy calves [PDF]

, 2015
peer-reviewedBackground There is a need to improve vaccination against respiratory pathogens in calves by stimulation of local immunity at the site of pathogen entry at an early stage in life. Ideally such a vaccine preparation would not be inhibited by
A Menanteau-Horta, A Vila, AR Peters, B Morein, B Morein, Bernadette Earley, BJF Bradshaw, BM Adair, Bryan Markey, C Pilette, CA Siegrist, CX Song, DG Bryson, DP Greenberg, EM Liebler-Tenorio, F Alexis, F Mansoor, Fawad Mansoor, FM Buonaguro, HM Chen, I Vangeel, J Phillips, J Pollock, JE Crowe, Joseph P. Cassidy, JS Salt, K Tahara, KJ Wiechelman, M Garinot, M Higaki, Michael D. Welsh, ML Hans, MS Lee, OV Kavanagh, PE Shewen, PK Smith, PR Wood, RE Brown, RM Zinkernagel, S Lofthouse, Simon Doherty, TG Kimman, YJ Kwon   +42 more
core   +1 more source

Recent Advances in Intranasal Administration for Brain-Targeting Delivery: A Comprehensive Review of Lipid-Based Nanoparticles and Stimuli-Responsive Gel Formulations

International Journal of Nanomedicine
Addressing disorders related to the central nervous system (CNS) remains a complex challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry of external substances into the brain tissue.
Jain Koo, Chaemin Lim, K. Oh
semanticscholar   +1 more source

Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6‐Hydroxydopamine‐Treated Rats

Stem Cells Translational Medicine, 2019
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting millions of people worldwide. At present, there is no effective cure for PD; treatments are symptomatic and do not halt progression of neurodegeneration ...
Karīna Narbute, V. Pilipenko, J. Pupure, Z. Dzirkale, Ugnė Jonavičė, V. Tunaitis, Karolina Kriaučiūnaitė, Akvilė Jarmalavičiūtė, B. Jansone, V. Kluša, A. Pivoriūnas   +10 more
semanticscholar   +1 more source

The pharmacokinetics of intranasal droperidol in volunteers characterised via population modelling

SAGE Open Medicine, 2018
Background: Droperidol is used parenterally to treat nausea and vomiting, migraine and acute behavioural disturbance. Intranasal use is not reported for droperidol.
Isabelle Cooper, Cornelia B Landersdorfer, Ashley Gordon St John, Andis Graudins   +3 more
doaj   +1 more source

Development and evaluation of vinpocetine inclusion complex for brain targeting

Asian Journal of Pharmaceutical Sciences, 2015
The objective of this paper is to prepare vinpocetine (VIN) inclusion complex and evaluate its brain targeting effect after intranasal administration. In the present study, VIN inclusion complex was prepared in order to increase its solubility. Stability
Jiaojiao Ding, Jinfeng Li, Shirui Mao
doaj   +1 more source

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome [PDF]

, 2018
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles.
Arena, Andrea, Barone, Eugenio, Blarzino, Carla, Butterfield, D. Allan, Di Domenico, Fabio, Lanzillotta, Chiara, Mosca, Luciana, Perluigi, Marzia, Tramutola, Antonella, Zuliani, Ilaria   +9 more
core   +3 more sources

Intranasal Administration of Mesenchymal Stem Cell-Derived Exosome Alleviates Hypoxic-Ischemic Brain Injury

Pharmaceutics
Hypoxic-ischemic brain injury arises from inadequate oxygen delivery to the brain, commonly occurring following cardiac arrest, which lacks effective treatments.
Takuma Ikeda, M. Kawabori, Yuyuan Zheng, Sho-ichi Yamaguchi, Shuho Gotoh, Yo Nakahara, Erika Yoshie, Miki Fujimura   +7 more
semanticscholar   +1 more source

Distribution of insulin in trigeminal nerve and brain after intranasal administration

Scientific Reports, 2019
In the brain, insulin acts as a growth factor, regulates energy homeostasis, and is involved in learning and memory acquisition. Many central nervous system (CNS) diseases are characterized by deficits in insulin signaling.
Jeffrey J. Lochhead, Kathryn L. Kellohen, P. Ronaldson, T. Davis   +3 more
semanticscholar   +1 more source

Advances and Challenges in Intranasal Delivery of Antipsychotic Agents Targeting the Central Nervous System

Frontiers in Pharmacology, 2022
Treatment of central nervous system (CNS) disorders is challenging using conventional delivery strategies and routes of administration because of the presence of the blood–brain barrier (BBB). This BBB restricts the permeation of most of the therapeutics
Manisha Pandey, Neha Jain, Jovita Kanoujia, Zahid Hussain, Bapi Gorain   +4 more
doaj   +1 more source