Development of a Vaginal Extracellular Matrix Hydrogel for Combating Genitourinary Syndrome of Menopause. [PDF]
Adv MaterIn this study, a vaginal specific ECM hydrogel (vECM) is developed, optimized for intravaginal topical administration, and evaluated for mitigatation of vaginal atrophy associated with menopause. When applied in a rat model of menopause, vECM improves vaginal epithelial thickness and stem cell phenotype, and despite topical application, vECM also ...
Zelus EI +6 more
europepmc +2 more sources
Fluconazole‐Induced Fixed Drug Eruption With Cross‐Reactivity to Clotrimazole—Confirmation With Patch Testing [PDF]
Case Reports in Dermatological MedicineFirst described in 1994, fixed drug eruption (FDE) to fluconazole is uncommon but possibly underdiagnosed. Of these, women with vaginal candidiasis remain the most affected, with on average more than four occurrences prior to diagnosis. We present a case of a 29‐year‐old female who presented after her third episode of an itchy, oedematous, blistering ...
Sron D +4 more
europepmc +2 more sources
Medicina, 2023 Background and Objectives: Preterm birth (PTB) is associated with important neonatal mortality and morbidity. The aim of this study was to retrospectively evaluate the average treatment effects on the treated and the efficacity of various therapeutic ...
Alina-Madalina Luca +12 more
doaj +1 more source
Lactoferrin. A natural glycoprotein involved in iron and inflammatory homeostasis [PDF]
, 2017 Human lactoferrin (hLf), an iron-binding multifunctional cationic glycoprotein secreted by exocrine glands and by neutrophils, is a key element of host defenses.
Cutone, Antimo +4 more
core +2 more sources
The role of diallyl thiosulfinate associated with nuciferine and diosgenin in the treatment of premature ejaculation: a pilot study [PDF]
, 2018 Objective: To assess the efficacy and safety of an association of diallyl thiosulfinate with nuciferine and diosgenin in the treatment of a group of patients suffering from premature ejaculation (PE), primary or secondary to erectile dysfunction (ED ...
Cai, Tommaso +10 more
core +2 more sources
Rationale and safety assessment of a novel intravaginal drug-delivery system with sustained DL-lactic acid release, intended for long-term protection of the vaginal microbiome [PDF]
, 2016 Bacterial vaginosis is a prevalent state of dysbiosis of the vaginal microbiota with wide-ranging impact on human reproductive health. Based on recent insights in community ecology of the vaginal microbiome, we hypothesize that sustained vaginal DL ...
Remon, Jean Paul +2 more
core +4 more sources
Interferon lambda protects the female reproductive tract against Zika virus infection [PDF]
, 2019 Zika virus infections can cause devastating congenital birth defects but the underlying interactions with the host immune system are not well understood.
Arora, Nitin +7 more
core +3 more sources
Novel in situ gelling vaginal sponges of sildenafil citrate-based cubosomes for uterine targeting
Drug Delivery, 2018 Sildenafil citrate (SIL), a type 5-specific phosphodiesterase inhibitor, demonstrates valuable results in the management of infertility in women; however, the absence of vaginal dosage form in addition to the associated oral adverse effects minimize its ...
Heba M. Aboud +3 more
doaj +1 more source
Menopause Review, 2019 The climacteric is considered a natural phase in a woman’s aging process and is defined as the period starting from the decline in ovarian activity until after the end of ovarian function. Genitourinary syndrome of menopause (GSM) is commonly observed in
Valentina Lucia La Rosa +8 more
doaj +1 more source
Zika virus preferentially replicates in the female reproductive tract after vaginal inoculation of rhesus macaques. [PDF]
, 2017 Zika virus (ZIKV) is a mosquito-transmitted virus that can cause severe defects in an infected fetus. ZIKV is also transmitted by sexual contact, although the relative importance of sexual transmission is unclear.
Busch, Michael +11 more
core +1 more source